Program

Causal Mechanistic Flows with regulons in program Pr-42

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CMYA5up-regulatesKLF13activatesR-2041-1.319259Pr-42
DIS3down-regulatesKLF13activatesR-2041-1.319259Pr-42
FAM46Cup-regulatesKLF13activatesR-2041-1.319259Pr-42
FAT3down-regulatesKLF13activatesR-2041-1.319259Pr-42
FGFR3down-regulatesKLF13activatesR-2041-1.319259Pr-42
IRF4down-regulatesKLF13activatesR-2041-1.319259Pr-42
MAXdown-regulatesKLF13activatesR-2041-1.319259Pr-42
MUC16up-regulatesKLF13activatesR-2041-1.319259Pr-42
NEBup-regulatesKLF13activatesR-2041-1.319259Pr-42
NRASup-regulatesKLF13activatesR-2041-1.319259Pr-42
PRKD2down-regulatesKLF13activatesR-2041-1.319259Pr-42
t(11;14)down-regulatesKLF13activatesR-2041-1.319259Pr-42
RNASeq_CCND3_Calldown-regulatesKLF13activatesR-2041-1.319259Pr-42
RNASeq_FGFR3_Calldown-regulatesKLF13activatesR-2041-1.319259Pr-42
RNASeq_MAFA_Calldown-regulatesKLF13activatesR-2041-1.319259Pr-42
RNASeq_MAFB_Calldown-regulatesKLF13activatesR-2041-1.319259Pr-42
t(14;16)down-regulatesKLF13activatesR-2041-1.319259Pr-42
t(4;14)down-regulatesKLF13activatesR-2041-1.319259Pr-42
ROBO1up-regulatesKLF13activatesR-2041-1.319259Pr-42
SVILdown-regulatesKLF13activatesR-2041-1.319259Pr-42
TRIOdown-regulatesKLF13activatesR-2041-1.319259Pr-42
t(11;14)_cytogeneticdown-regulatesKLF13activatesR-2041-1.319259Pr-42
t(14;16)_cytogeneticdown-regulatesKLF13activatesR-2041-1.319259Pr-42
t(4;14)_cytogeneticdown-regulatesKLF13activatesR-2041-1.319259Pr-42
CMYA5down-regulatesRARArepressesR-155-1.7633516Pr-42
IRF4up-regulatesRARArepressesR-155-1.7633516Pr-42
t(11;14)up-regulatesRARArepressesR-155-1.7633516Pr-42
t(11;14)_cytogeneticup-regulatesRARArepressesR-155-1.7633516Pr-42
AHNAK2down-regulatesETV3activatesR-2539-1.809066Pr-42
del13up-regulatesETV3activatesR-2539-1.809066Pr-42
RNASeq_MAFA_Calldown-regulatesTRIM28activatesR-1503-1.871018Pr-42
DIS3down-regulatesPLAG1activatesR-1525-2.0993110Pr-42
FAM46Cup-regulatesPLAG1activatesR-1525-2.0993110Pr-42
FRAS1down-regulatesPLAG1activatesR-1525-2.0993110Pr-42
HUWE1down-regulatesPLAG1activatesR-1525-2.0993110Pr-42
IRF4down-regulatesPLAG1activatesR-1525-2.0993110Pr-42
KDM3Bdown-regulatesPLAG1activatesR-1525-2.0993110Pr-42
t(11;14)down-regulatesPLAG1activatesR-1525-2.0993110Pr-42
RNASeq_MAFA_Calldown-regulatesPLAG1activatesR-1525-2.0993110Pr-42
ROBO2down-regulatesPLAG1activatesR-1525-2.0993110Pr-42
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-1525-2.0993110Pr-42
DIS3down-regulatesHINFPactivatesR-2628-2.298756Pr-42
FAM46Cup-regulatesHINFPactivatesR-2628-2.298756Pr-42
IRF4down-regulatesHINFPactivatesR-2628-2.298756Pr-42
MAXdown-regulatesHINFPactivatesR-2628-2.298756Pr-42
NRASup-regulatesHINFPactivatesR-2628-2.298756Pr-42
PRKD2down-regulatesHINFPactivatesR-2628-2.298756Pr-42
t(11;14)down-regulatesHINFPactivatesR-2628-2.298756Pr-42
RNASeq_FGFR3_Calldown-regulatesHINFPactivatesR-2628-2.298756Pr-42
RNASeq_MAFA_Calldown-regulatesHINFPactivatesR-2628-2.298756Pr-42
RNASeq_MAFB_Calldown-regulatesHINFPactivatesR-2628-2.298756Pr-42
t(14;16)down-regulatesHINFPactivatesR-2628-2.298756Pr-42
t(4;14)down-regulatesHINFPactivatesR-2628-2.298756Pr-42
TRIOdown-regulatesHINFPactivatesR-2628-2.298756Pr-42
t(14;16)_cytogeneticdown-regulatesHINFPactivatesR-2628-2.298756Pr-42
t(4;14)_cytogeneticdown-regulatesHINFPactivatesR-2628-2.298756Pr-42
KDM3Bdown-regulatesHLXactivatesR-2766-3.533976Pr-42
RNASeq_FGFR3_Callup-regulatesHLXactivatesR-2766-3.533976Pr-42
t(4;14)up-regulatesHLXactivatesR-2766-3.533976Pr-42
t(14;16)_cytogeneticdown-regulatesHLXactivatesR-2766-3.533976Pr-42
DCHS1up-regulatesMAZrepressesR-509-4.016217Pr-42
DIS3up-regulatesMAZrepressesR-509-4.016217Pr-42
DNAH10up-regulatesMAZrepressesR-509-4.016217Pr-42
FAM46Cdown-regulatesMAZrepressesR-509-4.016217Pr-42
FAT3up-regulatesMAZrepressesR-509-4.016217Pr-42
FGFR3up-regulatesMAZrepressesR-509-4.016217Pr-42
NRASdown-regulatesMAZrepressesR-509-4.016217Pr-42
PRKD2up-regulatesMAZrepressesR-509-4.016217Pr-42
RNASeq_FGFR3_Callup-regulatesMAZrepressesR-509-4.016217Pr-42
RNASeq_MAFA_Callup-regulatesMAZrepressesR-509-4.016217Pr-42
RNASeq_MAFB_Callup-regulatesMAZrepressesR-509-4.016217Pr-42
t(14;16)up-regulatesMAZrepressesR-509-4.016217Pr-42
t(4;14)up-regulatesMAZrepressesR-509-4.016217Pr-42
SETD2up-regulatesMAZrepressesR-509-4.016217Pr-42
TP53up-regulatesMAZrepressesR-509-4.016217Pr-42
TRIOup-regulatesMAZrepressesR-509-4.016217Pr-42
amp1qup-regulatesMAZrepressesR-509-4.016217Pr-42
t(14;16)_cytogeneticup-regulatesMAZrepressesR-509-4.016217Pr-42
t(4;14)_cytogeneticup-regulatesMAZrepressesR-509-4.016217Pr-42
DIS3down-regulatesKLF16activatesR-2700-4.301298Pr-42
FGFR3down-regulatesKLF16activatesR-2700-4.301298Pr-42
NRASup-regulatesKLF16activatesR-2700-4.301298Pr-42
t(11;14)down-regulatesKLF16activatesR-2700-4.301298Pr-42
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2700-4.301298Pr-42
t(4;14)down-regulatesKLF16activatesR-2700-4.301298Pr-42
ROBO1up-regulatesKLF16activatesR-2700-4.301298Pr-42
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2700-4.301298Pr-42
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2700-4.301298Pr-42
DCHS1up-regulatesSP1repressesR-2735-4.3471611Pr-42
DIS3up-regulatesSP1repressesR-2735-4.3471611Pr-42
FAM46Cdown-regulatesSP1repressesR-2735-4.3471611Pr-42
FGFR3up-regulatesSP1repressesR-2735-4.3471611Pr-42
IRF4up-regulatesSP1repressesR-2735-4.3471611Pr-42
RNASeq_FGFR3_Callup-regulatesSP1repressesR-2735-4.3471611Pr-42
RNASeq_MAFA_Callup-regulatesSP1repressesR-2735-4.3471611Pr-42
RNASeq_MAFB_Callup-regulatesSP1repressesR-2735-4.3471611Pr-42
t(14;16)up-regulatesSP1repressesR-2735-4.3471611Pr-42
t(4;14)up-regulatesSP1repressesR-2735-4.3471611Pr-42
TRIOup-regulatesSP1repressesR-2735-4.3471611Pr-42
ZNF462up-regulatesSP1repressesR-2735-4.3471611Pr-42
t(14;16)_cytogeneticup-regulatesSP1repressesR-2735-4.3471611Pr-42
t(4;14)_cytogeneticup-regulatesSP1repressesR-2735-4.3471611Pr-42
DNAH10down-regulatesNR2F6activatesR-1381-4.383696Pr-42
FGFR3down-regulatesNR2F6activatesR-1381-4.383696Pr-42
HUWE1down-regulatesNR2F6activatesR-1381-4.383696Pr-42
IRF4down-regulatesNR2F6activatesR-1381-4.383696Pr-42
PRKD2down-regulatesNR2F6activatesR-1381-4.383696Pr-42
t(11;14)down-regulatesNR2F6activatesR-1381-4.383696Pr-42
RNASeq_FGFR3_Calldown-regulatesNR2F6activatesR-1381-4.383696Pr-42
RNASeq_MAFA_Calldown-regulatesNR2F6activatesR-1381-4.383696Pr-42
RNASeq_MAFB_Calldown-regulatesNR2F6activatesR-1381-4.383696Pr-42
t(14;16)down-regulatesNR2F6activatesR-1381-4.383696Pr-42
MYCdown-regulatesNR2F6activatesR-1381-4.383696Pr-42
t(4;14)down-regulatesNR2F6activatesR-1381-4.383696Pr-42
t(11;14)_cytogeneticdown-regulatesNR2F6activatesR-1381-4.383696Pr-42
t(4;14)_cytogeneticdown-regulatesNR2F6activatesR-1381-4.383696Pr-42

Regulons in program Pr-42

Regulon Cox Hazard Ratio # genes # causal flows
R-2041-1.31925924
R-155-1.76335164
R-2539-1.8090662
R-1503-1.8710181
R-1525-2.099311010
R-2628-2.29875615
R-2766-3.5339764
R-509-4.01621719
R-2700-4.3012989
R-2735-4.347161114
R-1381-4.38369614

Genes in program Pr-42

EnsEMBL IdEntrez IdPreferred
ENSG00000198001 51135IRAK4
ENSG00000213809 22914KLRK1
ENSG00000214274 283ANG
ENSG00000217128 96459FNIP1
ENSG00000241399 9936CD302
ENSG00000255587 401258RAB44

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions