Program

Causal Mechanistic Flows with regulons in program Pr-41

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_MAFA_Calldown-regulatesNR2F6repressesR-13820.0106126Pr-41
RNASeq_MAFB_Calldown-regulatesNR2F6repressesR-13820.0106126Pr-41
t(14;16)down-regulatesNR2F6repressesR-13820.0106126Pr-41
RNASeq_MAFB_Callup-regulatesENSG00000186564repressesR-4790.056684612Pr-41
t(14;16)up-regulatesENSG00000186564repressesR-4790.056684612Pr-41
TRAF3up-regulatesENSG00000186564repressesR-4790.056684612Pr-41
t(11;14)up-regulatesFOXJ2repressesR-14360.097428724Pr-41
t(14;16)up-regulatesFOXJ2repressesR-14360.097428724Pr-41
t(4;14)up-regulatesFOXJ2repressesR-14360.097428724Pr-41
amp1qup-regulatesFOXJ2repressesR-14360.097428724Pr-41
del13up-regulatesFOXJ2repressesR-14360.097428724Pr-41
DSTdown-regulatesIRF7activatesR-1086-0.24388715Pr-41
FLGdown-regulatesIRF7activatesR-1086-0.24388715Pr-41
NRASup-regulatesIRF7activatesR-1086-0.24388715Pr-41
RNASeq_FGFR3_Calldown-regulatesIRF7activatesR-1086-0.24388715Pr-41
t(4;14)down-regulatesIRF7activatesR-1086-0.24388715Pr-41
TP53up-regulatesIRF7activatesR-1086-0.24388715Pr-41
TRAF3down-regulatesIRF7activatesR-1086-0.24388715Pr-41
amp1qdown-regulatesIRF7activatesR-1086-0.24388715Pr-41
del13down-regulatesIRF7activatesR-1086-0.24388715Pr-41
t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1086-0.24388715Pr-41
t(11;14)up-regulatesPOU2F1repressesR-83-0.31020828Pr-41
MYCdown-regulatesPOU2F1repressesR-83-0.31020828Pr-41
amp1qup-regulatesPOU2F1repressesR-83-0.31020828Pr-41
del13up-regulatesPOU2F1repressesR-83-0.31020828Pr-41
t(11;14)_cytogeneticup-regulatesPOU2F1repressesR-83-0.31020828Pr-41
amp1qup-regulatesELF2repressesR-9710.55001313Pr-41
del13up-regulatesELF2repressesR-9710.55001313Pr-41
CACNA1Hup-regulatesPEBP1repressesR-1757-0.7141696Pr-41
DIS3up-regulatesPEBP1repressesR-1757-0.7141696Pr-41
FAM46Cdown-regulatesPEBP1repressesR-1757-0.7141696Pr-41
FGFR3up-regulatesPEBP1repressesR-1757-0.7141696Pr-41
IRF4up-regulatesPEBP1repressesR-1757-0.7141696Pr-41
NRASdown-regulatesPEBP1repressesR-1757-0.7141696Pr-41
t(11;14)up-regulatesPEBP1repressesR-1757-0.7141696Pr-41
RNASeq_FGFR3_Callup-regulatesPEBP1repressesR-1757-0.7141696Pr-41
t(4;14)up-regulatesPEBP1repressesR-1757-0.7141696Pr-41
TRIOup-regulatesPEBP1repressesR-1757-0.7141696Pr-41
amp1qup-regulatesPEBP1repressesR-1757-0.7141696Pr-41
del13up-regulatesPEBP1repressesR-1757-0.7141696Pr-41
t(11;14)_cytogeneticup-regulatesPEBP1repressesR-1757-0.7141696Pr-41
t(4;14)_cytogeneticup-regulatesPEBP1repressesR-1757-0.7141696Pr-41
FGFR3up-regulatesHMBOX1repressesR-2378-0.7322269Pr-41
IRF4up-regulatesHMBOX1repressesR-2378-0.7322269Pr-41
t(11;14)up-regulatesHMBOX1repressesR-2378-0.7322269Pr-41
RNASeq_MAFB_Callup-regulatesHMBOX1repressesR-2378-0.7322269Pr-41
TRIOup-regulatesHMBOX1repressesR-2378-0.7322269Pr-41
DIS3up-regulatesATF2repressesR-30911.325667Pr-41
FAM46Cdown-regulatesATF2repressesR-30911.325667Pr-41
FGFR3up-regulatesATF2repressesR-30911.325667Pr-41
IRF4up-regulatesATF2repressesR-30911.325667Pr-41
t(11;14)up-regulatesATF2repressesR-30911.325667Pr-41
RNASeq_FGFR3_Callup-regulatesATF2repressesR-30911.325667Pr-41
t(4;14)up-regulatesATF2repressesR-30911.325667Pr-41
TRAF3up-regulatesATF2repressesR-30911.325667Pr-41
TRIOup-regulatesATF2repressesR-30911.325667Pr-41
t(11;14)_cytogeneticup-regulatesATF2repressesR-30911.325667Pr-41
t(4;14)_cytogeneticup-regulatesATF2repressesR-30911.325667Pr-41
DIS3up-regulatesSPIBrepressesR-677-3.409867Pr-41
FAM46Cdown-regulatesSPIBrepressesR-677-3.409867Pr-41
MACF1up-regulatesSPIBrepressesR-677-3.409867Pr-41
NRASdown-regulatesSPIBrepressesR-677-3.409867Pr-41
RNASeq_FGFR3_Callup-regulatesSPIBrepressesR-677-3.409867Pr-41
RNASeq_MAFA_Callup-regulatesSPIBrepressesR-677-3.409867Pr-41
RNASeq_MAFB_Callup-regulatesSPIBrepressesR-677-3.409867Pr-41
t(14;16)up-regulatesSPIBrepressesR-677-3.409867Pr-41
t(4;14)up-regulatesSPIBrepressesR-677-3.409867Pr-41
TRIOup-regulatesSPIBrepressesR-677-3.409867Pr-41
amp1qup-regulatesSPIBrepressesR-677-3.409867Pr-41
del13up-regulatesSPIBrepressesR-677-3.409867Pr-41
t(4;14)_cytogeneticup-regulatesSPIBrepressesR-677-3.409867Pr-41

Regulons in program Pr-41

Regulon Cox Hazard Ratio # genes # causal flows
R-13820.01061263
R-4790.0566846123
R-14360.0974287245
R-1086-0.2438871510
R-83-0.310208285
R-9710.550013132
R-1757-0.714169614
R-2378-0.73222695
R-30911.32566711
R-677-3.40986713

Genes in program Pr-41

EnsEMBL IdEntrez IdPreferred
ENSG00000175544 57010CABP4
ENSG00000175793 2810SFN
ENSG00000176105 7525YES1
ENSG00000177613 23283CSTF2T
ENSG00000178502 55175KLHL11
ENSG00000182108 28955DEXI
ENSG00000184557 9021SOCS3
ENSG00000184678 8349HIST2H2BE
ENSG00000198105 57209ZNF248

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions