Program

Causal Mechanistic Flows with regulons in program Pr-139

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CYLDup-regulatesENSG00000177374repressesR-23640.3428976Pr-139
MAXdown-regulatesENSG00000177374repressesR-23640.3428976Pr-139
NFKB2up-regulatesENSG00000177374repressesR-23640.3428976Pr-139
PRKD2down-regulatesENSG00000177374repressesR-23640.3428976Pr-139
t(11;14)down-regulatesENSG00000177374repressesR-23640.3428976Pr-139
RNASeq_FGFR3_Calldown-regulatesENSG00000177374repressesR-23640.3428976Pr-139
RNASeq_MAFA_Callup-regulatesENSG00000177374repressesR-23640.3428976Pr-139
t(4;14)down-regulatesENSG00000177374repressesR-23640.3428976Pr-139
t(4;14)_cytogeneticdown-regulatesENSG00000177374repressesR-23640.3428976Pr-139
amp1qup-regulatesMAFKactivatesR-2807-0.43106510Pr-139
NRASdown-regulatesTCF4repressesR-30030.8511527Pr-139
t(11;14)down-regulatesTCF4repressesR-30030.8511527Pr-139
t(11;14)_cytogeneticdown-regulatesTCF4repressesR-30030.8511527Pr-139
RNASeq_MAFA_Callup-regulatesZNF691repressesR-30091.3948Pr-139
BRAFup-regulatesATF2activatesR-30931.866497Pr-139
DIS3up-regulatesATF2activatesR-30931.866497Pr-139
FGFR3up-regulatesATF2activatesR-30931.866497Pr-139
HUWE1up-regulatesATF2activatesR-30931.866497Pr-139
PRKD2up-regulatesATF2activatesR-30931.866497Pr-139
t(11;14)up-regulatesATF2activatesR-30931.866497Pr-139
RNASeq_FGFR3_Callup-regulatesATF2activatesR-30931.866497Pr-139
t(4;14)up-regulatesATF2activatesR-30931.866497Pr-139
t(11;14)_cytogeneticup-regulatesATF2activatesR-30931.866497Pr-139
t(4;14)_cytogeneticup-regulatesATF2activatesR-30931.866497Pr-139
ATMup-regulatesSMAD3repressesR-2967-1.988076Pr-139
DIS3up-regulatesSMAD3repressesR-2967-1.988076Pr-139
DMDup-regulatesSMAD3repressesR-2967-1.988076Pr-139
FLGup-regulatesSMAD3repressesR-2967-1.988076Pr-139
IRF4up-regulatesSMAD3repressesR-2967-1.988076Pr-139
KRASdown-regulatesSMAD3repressesR-2967-1.988076Pr-139
NRASdown-regulatesSMAD3repressesR-2967-1.988076Pr-139
RNASeq_MAFA_Callup-regulatesSMAD3repressesR-2967-1.988076Pr-139
RNASeq_MAFB_Callup-regulatesSMAD3repressesR-2967-1.988076Pr-139
t(14;16)up-regulatesSMAD3repressesR-2967-1.988076Pr-139
ROBO2up-regulatesSMAD3repressesR-2967-1.988076Pr-139
t(11;14)_cytogeneticup-regulatesSMAD3repressesR-2967-1.988076Pr-139
t(14;16)_cytogeneticup-regulatesSMAD3repressesR-2967-1.988076Pr-139
DIS3up-regulatesCEBPBactivatesR-17762.11746Pr-139
FAM46Cdown-regulatesCEBPBactivatesR-17762.11746Pr-139
HUWE1up-regulatesCEBPBactivatesR-17762.11746Pr-139
IRF4up-regulatesCEBPBactivatesR-17762.11746Pr-139
MAXup-regulatesCEBPBactivatesR-17762.11746Pr-139
NFKB2down-regulatesCEBPBactivatesR-17762.11746Pr-139
PRKD2up-regulatesCEBPBactivatesR-17762.11746Pr-139
t(11;14)up-regulatesCEBPBactivatesR-17762.11746Pr-139
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-17762.11746Pr-139
t(4;14)up-regulatesCEBPBactivatesR-17762.11746Pr-139
t(11;14)_cytogeneticup-regulatesCEBPBactivatesR-17762.11746Pr-139
t(4;14)_cytogeneticup-regulatesCEBPBactivatesR-17762.11746Pr-139
BRAFup-regulatesZNF219activatesR-22122.1466512Pr-139
DIS3up-regulatesZNF219activatesR-22122.1466512Pr-139
KRASup-regulatesZNF219activatesR-22122.1466512Pr-139
PRKD2up-regulatesZNF219activatesR-22122.1466512Pr-139
t(11;14)up-regulatesZNF219activatesR-22122.1466512Pr-139
RNASeq_CCND2_Callup-regulatesZNF219activatesR-22122.1466512Pr-139
RNASeq_FGFR3_Callup-regulatesZNF219activatesR-22122.1466512Pr-139
t(4;14)up-regulatesZNF219activatesR-22122.1466512Pr-139
SYNE1down-regulatesZNF219activatesR-22122.1466512Pr-139
t(11;14)_cytogeneticup-regulatesZNF219activatesR-22122.1466512Pr-139
t(4;14)_cytogeneticup-regulatesZNF219activatesR-22122.1466512Pr-139
DSCAML1down-regulatesZNF740activatesR-397-2.245786Pr-139
DSTdown-regulatesZNF740activatesR-397-2.245786Pr-139
FLGdown-regulatesZNF740activatesR-397-2.245786Pr-139
PCLOdown-regulatesZNF740activatesR-397-2.245786Pr-139
t(11;14)up-regulatesZNF740activatesR-397-2.245786Pr-139
RNASeq_MAFA_Calldown-regulatesZNF740activatesR-397-2.245786Pr-139
t(14;16)down-regulatesZNF740activatesR-397-2.245786Pr-139
t(4;14)down-regulatesZNF740activatesR-397-2.245786Pr-139
ROBO1down-regulatesZNF740activatesR-397-2.245786Pr-139
SP140down-regulatesZNF740activatesR-397-2.245786Pr-139
TTNdown-regulatesZNF740activatesR-397-2.245786Pr-139
amp1qdown-regulatesZNF740activatesR-397-2.245786Pr-139
del13down-regulatesZNF740activatesR-397-2.245786Pr-139
t(11;14)_cytogeneticup-regulatesZNF740activatesR-397-2.245786Pr-139
t(14;16)_cytogeneticdown-regulatesZNF740activatesR-397-2.245786Pr-139
DNAH10down-regulatesMZF1activatesR-3022-2.322978Pr-139
FAT1down-regulatesMZF1activatesR-3022-2.322978Pr-139
FGFR3down-regulatesMZF1activatesR-3022-2.322978Pr-139
IRF4down-regulatesMZF1activatesR-3022-2.322978Pr-139
NRASup-regulatesMZF1activatesR-3022-2.322978Pr-139
PRKD2down-regulatesMZF1activatesR-3022-2.322978Pr-139
t(11;14)down-regulatesMZF1activatesR-3022-2.322978Pr-139
RNASeq_FGFR3_Calldown-regulatesMZF1activatesR-3022-2.322978Pr-139
RNASeq_MAFA_Calldown-regulatesMZF1activatesR-3022-2.322978Pr-139
t(14;16)down-regulatesMZF1activatesR-3022-2.322978Pr-139
t(4;14)down-regulatesMZF1activatesR-3022-2.322978Pr-139
del13down-regulatesMZF1activatesR-3022-2.322978Pr-139
t(11;14)_cytogeneticdown-regulatesMZF1activatesR-3022-2.322978Pr-139
t(14;16)_cytogeneticdown-regulatesMZF1activatesR-3022-2.322978Pr-139
t(4;14)_cytogeneticdown-regulatesMZF1activatesR-3022-2.322978Pr-139
DIS3down-regulatesPLAG1repressesR-15242.4623911Pr-139
t(11;14)down-regulatesPLAG1repressesR-15242.4623911Pr-139
t(11;14)_cytogeneticdown-regulatesPLAG1repressesR-15242.4623911Pr-139

Regulons in program Pr-139

Regulon Cox Hazard Ratio # genes # causal flows
R-23640.34289769
R-2807-0.431065101
R-30030.85115273
R-30091.39481
R-30931.86649710
R-2967-1.98807613
R-17762.1174612
R-22122.146651211
R-397-2.24578615
R-3022-2.32297815
R-15242.46239113

Genes in program Pr-139

EnsEMBL IdEntrez IdPreferred
ENSG00000179010 93621MRFAP1
ENSG00000180228 8575PRKRA
ENSG00000186118
ENSG00000198604 11177BAZ1A
ENSG00000215784 728833FAM72D
ENSG00000230124 100527964LHX4-AS1
ENSG00000242852 163051ZNF709
ENSG00000243749 100506144TMEM35B
ENSG00000253719 552889ATXN7L3B
ENSG00000257335
ENSG00000162599 4774NFIA

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions