Program

Causal Mechanistic Flows with regulons in program Pr-133

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)down-regulatesSTAT1activatesR-3071-0.014543210Pr-133
TP53up-regulatesSTAT1activatesR-3071-0.014543210Pr-133
del17up-regulatesSTAT1activatesR-3071-0.014543210Pr-133
ASXL3down-regulatesZNF410repressesR-1940-0.2010536Pr-133
NEBdown-regulatesZNF410repressesR-1940-0.2010536Pr-133
t(14;16)up-regulatesZNF410repressesR-1940-0.2010536Pr-133
TACC2down-regulatesZNF410repressesR-1940-0.2010536Pr-133
amp1qup-regulatesZNF410repressesR-1940-0.2010536Pr-133
del13up-regulatesZNF410repressesR-1940-0.2010536Pr-133
NEBdown-regulatesIRX3repressesR-22310.2177837Pr-133
del17down-regulatesIRX3repressesR-22310.2177837Pr-133
PTPRDup-regulatesTP53activatesR-372-0.2611519Pr-133
t(11;14)down-regulatesTP53activatesR-372-0.2611519Pr-133
t(14;16)down-regulatesTP53activatesR-372-0.2611519Pr-133
amp1qdown-regulatesTP53activatesR-372-0.2611519Pr-133
del13down-regulatesTP53activatesR-372-0.2611519Pr-133
t(11;14)up-regulatesNFATC1repressesR-22001.677619Pr-133
t(14;16)up-regulatesNFATC1repressesR-22001.677619Pr-133
del13up-regulatesNFATC1repressesR-22001.677619Pr-133
DNAH10up-regulatesE2F2activatesR-29451.887459Pr-133
DNAH5up-regulatesE2F2activatesR-29451.887459Pr-133
FAT3up-regulatesE2F2activatesR-29451.887459Pr-133
MACF1up-regulatesE2F2activatesR-29451.887459Pr-133
RNASeq_MAFA_Callup-regulatesE2F2activatesR-29451.887459Pr-133
RNASeq_MAFB_Callup-regulatesE2F2activatesR-29451.887459Pr-133
t(14;16)up-regulatesE2F2activatesR-29451.887459Pr-133
SYNE1up-regulatesE2F2activatesR-29451.887459Pr-133
TP53up-regulatesE2F2activatesR-29451.887459Pr-133
del17up-regulatesE2F2activatesR-29451.887459Pr-133
t(14;16)_cytogeneticup-regulatesE2F2activatesR-29451.887459Pr-133
AHNAK2down-regulatesELF1repressesR-29892.947998Pr-133
NRASup-regulatesELF1repressesR-29892.947998Pr-133

Regulons in program Pr-133

Regulon Cox Hazard Ratio # genes # causal flows
R-3071-0.0145432103
R-1940-0.20105366
R-22310.21778372
R-372-0.26115195
R-22001.6776193
R-29451.88745911
R-29892.9479982

Genes in program Pr-133

EnsEMBL IdEntrez IdPreferred
ENSG00000175564 7352UCP3
ENSG00000177291 219770GJD4
ENSG00000177465 122970ACOT4
ENSG00000177733 10949HNRNPA0
ENSG00000206559 152098ZCWPW2
ENSG00000219607

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions