Program

Causal Mechanistic Flows with regulons in program Pr-131

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
BAI3down-regulatesTCF4repressesR-29990.73465113Pr-131
FGFR3up-regulatesTCF4repressesR-29990.73465113Pr-131
KDM3Bdown-regulatesTCF4repressesR-29990.73465113Pr-131
LTBup-regulatesTCF4repressesR-29990.73465113Pr-131
t(11;14)down-regulatesTCF4repressesR-29990.73465113Pr-131
RNASeq_FGFR3_Callup-regulatesTCF4repressesR-29990.73465113Pr-131
MYCdown-regulatesTCF4repressesR-29990.73465113Pr-131
t(4;14)up-regulatesTCF4repressesR-29990.73465113Pr-131
del13up-regulatesTCF4repressesR-29990.73465113Pr-131
t(11;14)_cytogeneticdown-regulatesTCF4repressesR-29990.73465113Pr-131
t(4;14)_cytogeneticup-regulatesTCF4repressesR-29990.73465113Pr-131
BAI3up-regulatesENSG00000165066activatesR-30800.96782410Pr-131
IRF4up-regulatesENSG00000165066activatesR-30800.96782410Pr-131
MAGEC1up-regulatesENSG00000165066activatesR-30800.96782410Pr-131
t(11;14)up-regulatesENSG00000165066activatesR-30800.96782410Pr-131
t(4;14)down-regulatesENSG00000165066activatesR-30800.96782410Pr-131
TP53up-regulatesENSG00000165066activatesR-30800.96782410Pr-131
amp1qdown-regulatesENSG00000165066activatesR-30800.96782410Pr-131
del13down-regulatesENSG00000165066activatesR-30800.96782410Pr-131
t(11;14)_cytogeneticup-regulatesENSG00000165066activatesR-30800.96782410Pr-131
MAGEC1down-regulatesETV6repressesR-7061.2884512Pr-131
RNASeq_FGFR3_Callup-regulatesETV6repressesR-7061.2884512Pr-131
t(4;14)up-regulatesETV6repressesR-7061.2884512Pr-131
amp1qup-regulatesETV6repressesR-7061.2884512Pr-131
del13up-regulatesETV6repressesR-7061.2884512Pr-131
del1pup-regulatesETV6repressesR-7061.2884512Pr-131
t(4;14)_cytogeneticup-regulatesETV6repressesR-7061.2884512Pr-131
FGFR3up-regulatesHOXD1repressesR-13031.328937Pr-131
KDM3Bdown-regulatesHOXD1repressesR-13031.328937Pr-131
LTBup-regulatesHOXD1repressesR-13031.328937Pr-131
t(11;14)down-regulatesHOXD1repressesR-13031.328937Pr-131
RNASeq_FGFR3_Callup-regulatesHOXD1repressesR-13031.328937Pr-131
MYCdown-regulatesHOXD1repressesR-13031.328937Pr-131
t(4;14)up-regulatesHOXD1repressesR-13031.328937Pr-131
amp1qup-regulatesHOXD1repressesR-13031.328937Pr-131
del13up-regulatesHOXD1repressesR-13031.328937Pr-131
t(11;14)_cytogeneticdown-regulatesHOXD1repressesR-13031.328937Pr-131
t(4;14)_cytogeneticup-regulatesHOXD1repressesR-13031.328937Pr-131
PTPRDdown-regulatesPOU2F1repressesR-791.3780731Pr-131
MYCdown-regulatesPOU2F1repressesR-791.3780731Pr-131
amp1qup-regulatesPOU2F1repressesR-791.3780731Pr-131
del13up-regulatesPOU2F1repressesR-791.3780731Pr-131
DIS3down-regulatesNR2C2repressesR-13872.3127111Pr-131
DNAH10down-regulatesNR2C2repressesR-13872.3127111Pr-131
HUWE1down-regulatesNR2C2repressesR-13872.3127111Pr-131
IRF4down-regulatesNR2C2repressesR-13872.3127111Pr-131
PCLOup-regulatesNR2C2repressesR-13872.3127111Pr-131
PRKD2down-regulatesNR2C2repressesR-13872.3127111Pr-131
t(11;14)down-regulatesNR2C2repressesR-13872.3127111Pr-131
RNASeq_MAFA_Calldown-regulatesNR2C2repressesR-13872.3127111Pr-131
t(11;14)_cytogeneticdown-regulatesNR2C2repressesR-13872.3127111Pr-131

Regulons in program Pr-131

Regulon Cox Hazard Ratio # genes # causal flows
R-29990.7346511311
R-30800.967824109
R-7061.28845127
R-13031.32893711
R-791.37807314
R-13872.31271119

Genes in program Pr-131

EnsEMBL IdEntrez IdPreferred
ENSG00000184787 7327UBE2G2
ENSG00000187672 26059ERC2
ENSG00000197818 23315SLC9A8
ENSG00000198146 54989ZNF770
ENSG00000198408 10724MGEA5
ENSG00000256683 59348ZNF350

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions