Program

Causal Mechanistic Flows with regulons in program Pr-111

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)down-regulatesZBTB3activatesR-1273-0.3207377Pr-111
t(11;14)_cytogeneticdown-regulatesZBTB3activatesR-1273-0.3207377Pr-111
t(11;14)up-regulatesENSG00000054598repressesR-10090.33049821Pr-111
del17down-regulatesENSG00000054598repressesR-10090.33049821Pr-111
FGFR3up-regulatesDBPactivatesR-2956-0.3738486Pr-111
t(11;14)down-regulatesDBPactivatesR-2956-0.3738486Pr-111
RNASeq_CCND2_Calldown-regulatesDBPactivatesR-2956-0.3738486Pr-111
RNASeq_FGFR3_Callup-regulatesDBPactivatesR-2956-0.3738486Pr-111
t(14;16)down-regulatesDBPactivatesR-2956-0.3738486Pr-111
t(4;14)up-regulatesDBPactivatesR-2956-0.3738486Pr-111
ROBO2down-regulatesDBPactivatesR-2956-0.3738486Pr-111
t(4;14)_cytogeneticup-regulatesDBPactivatesR-2956-0.3738486Pr-111
TRAF3down-regulatesELF4repressesR-23370.38940421Pr-111
del1pup-regulatesELF4repressesR-23370.38940421Pr-111
NEBdown-regulatesELF2repressesR-9830.6434218Pr-111
amp1qup-regulatesELF2repressesR-9830.6434218Pr-111
KIAA1109down-regulatesSMAD4activatesR-23560.7551678Pr-111
NRASdown-regulatesSMAD4activatesR-23560.7551678Pr-111
t(11;14)up-regulatesSMAD4activatesR-23560.7551678Pr-111
t(11;14)_cytogeneticup-regulatesSMAD4activatesR-23560.7551678Pr-111
del1pup-regulatesETV6repressesR-7110.78164310Pr-111
DCHS1up-regulatesNFYCactivatesR-299-0.9643076Pr-111
KALRNup-regulatesNFYCactivatesR-299-0.9643076Pr-111
RNASeq_MAFA_Callup-regulatesNFYCactivatesR-299-0.9643076Pr-111
RNASeq_MAFB_Callup-regulatesNFYCactivatesR-299-0.9643076Pr-111
amp1qdown-regulatesNFYCactivatesR-299-0.9643076Pr-111
RNASeq_FGFR3_Calldown-regulatesENSG00000162367repressesR-17080.97398318Pr-111
t(4;14)down-regulatesENSG00000162367repressesR-17080.97398318Pr-111
t(4;14)_cytogeneticdown-regulatesENSG00000162367repressesR-17080.97398318Pr-111
DCHS1up-regulatesATF2activatesR-30921.263467Pr-111
DIS3up-regulatesATF2activatesR-30921.263467Pr-111
FAM46Cdown-regulatesATF2activatesR-30921.263467Pr-111
FGFR3up-regulatesATF2activatesR-30921.263467Pr-111
IRF4up-regulatesATF2activatesR-30921.263467Pr-111
LTBup-regulatesATF2activatesR-30921.263467Pr-111
MAXup-regulatesATF2activatesR-30921.263467Pr-111
NRASdown-regulatesATF2activatesR-30921.263467Pr-111
PRKD2up-regulatesATF2activatesR-30921.263467Pr-111
t(11;14)up-regulatesATF2activatesR-30921.263467Pr-111
RNASeq_FGFR3_Callup-regulatesATF2activatesR-30921.263467Pr-111
t(4;14)up-regulatesATF2activatesR-30921.263467Pr-111
ZFHX3up-regulatesATF2activatesR-30921.263467Pr-111
t(11;14)_cytogeneticup-regulatesATF2activatesR-30921.263467Pr-111
t(14;16)_cytogeneticup-regulatesATF2activatesR-30921.263467Pr-111
t(4;14)_cytogeneticup-regulatesATF2activatesR-30921.263467Pr-111
DCHS1up-regulatesSP1activatesR-27211.3379224Pr-111
DIS3up-regulatesSP1activatesR-27211.3379224Pr-111
FAM46Cdown-regulatesSP1activatesR-27211.3379224Pr-111
FAT3up-regulatesSP1activatesR-27211.3379224Pr-111
FGFR3up-regulatesSP1activatesR-27211.3379224Pr-111
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27211.3379224Pr-111
t(4;14)up-regulatesSP1activatesR-27211.3379224Pr-111
SVILup-regulatesSP1activatesR-27211.3379224Pr-111
t(4;14)_cytogeneticup-regulatesSP1activatesR-27211.3379224Pr-111
DIS3up-regulatesSATB1activatesR-10741.3882814Pr-111
DMDdown-regulatesSATB1activatesR-10741.3882814Pr-111
EYSdown-regulatesSATB1activatesR-10741.3882814Pr-111
FGFR3up-regulatesSATB1activatesR-10741.3882814Pr-111
PRKD2up-regulatesSATB1activatesR-10741.3882814Pr-111
RNASeq_CCND2_Calldown-regulatesSATB1activatesR-10741.3882814Pr-111
RNASeq_CCND3_Calldown-regulatesSATB1activatesR-10741.3882814Pr-111
RNASeq_FGFR3_Callup-regulatesSATB1activatesR-10741.3882814Pr-111
t(4;14)up-regulatesSATB1activatesR-10741.3882814Pr-111
RYR1down-regulatesSATB1activatesR-10741.3882814Pr-111
t(4;14)_cytogeneticup-regulatesSATB1activatesR-10741.3882814Pr-111

Regulons in program Pr-111

Regulon Cox Hazard Ratio # genes # causal flows
R-1273-0.32073772
R-10090.330498212
R-2956-0.37384868
R-23370.389404212
R-9830.64342182
R-23560.75516784
R-7110.781643101
R-299-0.96430765
R-17080.973983183
R-30921.26346716
R-27211.33792249
R-10741.388281411

Genes in program Pr-111

EnsEMBL IdEntrez IdPreferred
ENSG00000178685 84875PARP10
ENSG00000178764 22882ZHX2
ENSG00000179348
ENSG00000179532 144132DNHD1
ENSG00000183617 116541MRPL54
ENSG00000184992 140707BRI3BP
ENSG00000185274
ENSG00000187605 200424TET3
ENSG00000187726 374407DNAJB13
ENSG00000197622 56882CDC42SE1
ENSG00000198242 6147RPL23A
ENSG00000198554 11169WDHD1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions