Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SOX7 - SRY-box transcription factor 7

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
83595 ENSG00000171056 SOX7 Q9BT81

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: SOX7

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
FGFR3SOX7activatesR-1298-2.01289Pr-91
PRKD2SOX7activatesR-1298-2.01289Pr-91
RNASeq_FGFR3_CallSOX7activatesR-1298-2.01289Pr-91
t(4;14)SOX7activatesR-1298-2.01289Pr-91
t(4;14)_cytogeneticSOX7activatesR-1298-2.01289Pr-91
FGFR3SOX7activatesR-1299-3.13574Pr-135
PRKD2SOX7activatesR-1299-3.13574Pr-135
RNASeq_FGFR3_CallSOX7activatesR-1299-3.13574Pr-135
t(4;14)SOX7activatesR-1299-3.13574Pr-135
RYR1SOX7activatesR-1299-3.13574Pr-135
amp1qSOX7activatesR-1299-3.13574Pr-135
del13SOX7activatesR-1299-3.13574Pr-135
DIS3SOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

NEBSOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

PRKD2SOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

RNASeq_FGFR3_CallSOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

t(4;14)SOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

amp1qSOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

del1pSOX7repressesR-13004.16587Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.