Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

FOXO3 - forkhead box O3

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
2309 ENSG00000118689 FOXO3 O43524

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: FOXO3

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
ABCA13FOXO3activatesR-2775-0.28044Pr-5
PKHD1L1FOXO3activatesR-2775-0.28044Pr-5
ABCA13FOXO3activatesR-2769-0.336939Pr-3
RNASeq_MAFA_CallFOXO3activatesR-2769-0.336939Pr-3
PKHD1L1FOXO3activatesR-2776-0.554448Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

ABCA13FOXO3activatesR-2768-0.725609Pr-6
DNAH10FOXO3activatesR-2777-0.982827Pr-27
HUWE1FOXO3activatesR-2777-0.982827Pr-27
IRF4FOXO3activatesR-2777-0.982827Pr-27
PRKD2FOXO3activatesR-2777-0.982827Pr-27
t(11;14)FOXO3activatesR-2777-0.982827Pr-27
TRAF3FOXO3activatesR-2777-0.982827Pr-27
t(11;14)_cytogeneticFOXO3activatesR-2777-0.982827Pr-27
ABCA13FOXO3activatesR-2774-1.22358Pr-10
RNASeq_MAFA_CallFOXO3activatesR-2774-1.22358Pr-10
DIS3FOXO3activatesR-2767-2.51658Pr-4
FAM46CFOXO3activatesR-2767-2.51658Pr-4
NRASFOXO3activatesR-2767-2.51658Pr-4
t(11;14)FOXO3activatesR-2767-2.51658Pr-4
RNASeq_MAFA_CallFOXO3activatesR-2767-2.51658Pr-4
SETD2FOXO3activatesR-2767-2.51658Pr-4
t(11;14)_cytogeneticFOXO3activatesR-2767-2.51658Pr-4
t(4;14)_cytogeneticFOXO3activatesR-2767-2.51658Pr-4
t(11;14)FOXO3activatesR-2772-2.97174Pr-11
t(11;14)_cytogeneticFOXO3activatesR-2772-2.97174Pr-11
RNASeq_MAFA_CallFOXO3repressesR-27703.05956Pr-73
ABCA13FOXO3activatesR-2771-3.30433Pr-100
DIS3FOXO3activatesR-2771-3.30433Pr-100
DNAH10FOXO3activatesR-2771-3.30433Pr-100
FAM46CFOXO3activatesR-2771-3.30433Pr-100
HUWE1FOXO3activatesR-2771-3.30433Pr-100
IRF4FOXO3activatesR-2771-3.30433Pr-100
NRASFOXO3activatesR-2771-3.30433Pr-100
PCLOFOXO3activatesR-2771-3.30433Pr-100
PKHD1L1FOXO3activatesR-2771-3.30433Pr-100
PRKD2FOXO3activatesR-2771-3.30433Pr-100
t(11;14)FOXO3activatesR-2771-3.30433Pr-100
RNASeq_MAFA_CallFOXO3activatesR-2771-3.30433Pr-100
SETD2FOXO3activatesR-2771-3.30433Pr-100
TRAF3FOXO3activatesR-2771-3.30433Pr-100
t(11;14)_cytogeneticFOXO3activatesR-2771-3.30433Pr-100
t(4;14)_cytogeneticFOXO3activatesR-2771-3.30433Pr-100
DIS3FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

DNAH10FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

FAM46CFOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

HUWE1FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

IRF4FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

NRASFOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

PRKD2FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(11;14)FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

SETD2FOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(11;14)_cytogeneticFOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(4;14)_cytogeneticFOXO3activatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.