Program

Causal Mechanistic Flows with regulons in program Pr-97

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CSMD1down-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

FGFR3up-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

GPR98down-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)down-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RNASeq_FGFR3_Callup-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RNASeq_MAFA_Calldown-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RNASeq_MAFB_Calldown-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(14;16)down-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(4;14)up-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)_cytogeneticdown-regulatesSOX4repressesR-21870.2534757Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

CYLDup-regulatesSPDEFactivatesR-1977-1.082936Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

IRF4down-regulatesSPDEFactivatesR-1977-1.082936Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

amp1qup-regulatesSPDEFactivatesR-1977-1.082936Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

del13up-regulatesSPDEFactivatesR-1977-1.082936Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

amp1qup-regulatesFOXK1activatesR-12091.172257Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

del13up-regulatesFOXK1activatesR-12091.172257Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

BRAFdown-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

DCHS1down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

DIS3down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

FAT3down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

IRF4down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

NRASup-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RELNdown-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RNASeq_MAFA_Calldown-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(14;16)down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

amp1qdown-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

del13down-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)_cytogeneticdown-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(14;16)_cytogeneticdown-regulatesMZF1repressesR-30261.490516Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

NRASdown-regulatesSMAD4activatesR-23542.229299Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)up-regulatesSMAD4activatesR-23542.229299Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RNASeq_MAFB_Callup-regulatesSMAD4activatesR-23542.229299Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(14;16)up-regulatesSMAD4activatesR-23542.229299Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

Regulons in program Pr-97

Regulon Cox Hazard Ratio # genes # causal flows
R-21870.253475710
R-1977-1.0829364
R-12091.1722572
R-30261.49051614
R-23542.2292994

Genes in program Pr-97

EnsEMBL IdEntrez IdPreferred
ENSG00000177683 168451THAP5
ENSG00000189403 3146HMGB1
ENSG00000196911 3841KPNA5
ENSG00000198925 79065ATG9A
ENSG00000250571 2738GLI4

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions