Program

Causal Mechanistic Flows with regulons in program Pr-29

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
del13up-regulatesFOXO1activatesR-1401-0.032772727Pr-29
t(14;16)_cytogeneticdown-regulatesFOXO1activatesR-1401-0.032772727Pr-29
amp1qup-regulatesMEF2AactivatesR-18700.20614329Pr-29
del13up-regulatesMEF2AactivatesR-18700.20614329Pr-29
t(11;14)up-regulatesMAFBactivatesR-1733-0.26821919Pr-29
t(11;14)up-regulatesPOU2F1activatesR-800.58319331Pr-29
amp1qup-regulatesPOU2F1activatesR-800.58319331Pr-29
del13up-regulatesPOU2F1activatesR-800.58319331Pr-29
CACNA1Hup-regulatesNFATC1activatesR-21970.66630618Pr-29
DNAH5down-regulatesNFATC1activatesR-21970.66630618Pr-29
IRF4up-regulatesNFATC1activatesR-21970.66630618Pr-29
t(11;14)up-regulatesNFATC1activatesR-21970.66630618Pr-29
t(11;14)_cytogeneticup-regulatesNFATC1activatesR-21970.66630618Pr-29
t(11;14)up-regulatesIKZF1activatesR-9930.67326513Pr-29
amp1qup-regulatesIKZF1activatesR-9930.67326513Pr-29
del13up-regulatesIKZF1activatesR-9930.67326513Pr-29
t(11;14)up-regulatesCEBPDactivatesR-13081.1133110Pr-29
DIS3up-regulatesCEBPEactivatesR-26831.6913212Pr-29
RNASeq_FGFR3_Callup-regulatesCEBPEactivatesR-26831.6913212Pr-29
SLIT2down-regulatesCEBPEactivatesR-26831.6913212Pr-29
del1pup-regulatesCEBPEactivatesR-26831.6913212Pr-29
t(11;14)up-regulatesBCL6activatesR-548-2.2574912Pr-29
SYNE1down-regulatesBCL6activatesR-548-2.2574912Pr-29
t(14;16)_cytogeneticdown-regulatesBCL6activatesR-548-2.2574912Pr-29

Regulons in program Pr-29

Regulon Cox Hazard Ratio # genes # causal flows
R-1401-0.0327727272
R-18700.206143292
R-1733-0.268219191
R-800.583193313
R-21970.666306185
R-9930.673265133
R-13081.11331101
R-26831.69132124
R-548-2.25749123

Genes in program Pr-29

EnsEMBL IdEntrez IdPreferred
ENSG00000175591 5029P2RY2
ENSG00000177409 219285SAMD9L
ENSG00000177854 8269TMEM187
ENSG00000182606 22906TRAK1
ENSG00000183831 339416ANKRD45
ENSG00000184007 8073PTP4A2
ENSG00000196357 147929ZNF565
ENSG00000212719 339263C17orf51
ENSG00000253958

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions