Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation RNASeq_CCND3_Call

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
HMGA1down-regulatesR-817-0.342996Pr-58
HMBOX1up-regulatesR-23820.378178Pr-62
HMGA1down-regulatesR-8320.407077Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

ETV2down-regulatesR-15110.447542Pr-62
BDP1down-regulatesR-8410.461691Pr-118
NFATC1up-regulatesR-2201-0.687031Pr-120
BORCS8-MEF2Bup-regulatesR-959-0.721458Pr-58
POU2F2down-regulatesR-2510-0.785808Pr-58
TGIF1up-regulatesR-2504-0.811771Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

NF1up-regulatesR-126-0.881056Pr-62
HMBOX1up-regulatesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ESRRAdown-regulatesR-27380.991373Pr-117
NFATC1up-regulatesR-2207-1.00385Pr-15
ETV2down-regulatesR-15091.05383Pr-60
FOSup-regulatesR-2190-1.08799Pr-58
NFATC1up-regulatesR-2204-1.15799Pr-10
KLF13down-regulatesR-2041-1.31925Pr-42
SATB1down-regulatesR-10741.38828Pr-111
ZNF740up-regulatesR-395-1.44318Pr-28
HMGA1down-regulatesR-825-1.46299Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

ZBTB3down-regulatesR-12711.5513Pr-117
ENSG00000168269down-regulatesR-1566-1.63414Pr-65
USF1up-regulatesR-1859-1.69216Pr-118
ESRRAdown-regulatesR-27411.72748Pr-125
RFX7down-regulatesR-2750-1.73199Pr-118
ESRRAdown-regulatesR-27361.82545Pr-60
BDP1down-regulatesR-842-1.83917Pr-118
ZNF740up-regulatesR-3841.98118Pr-52
USF1up-regulatesR-18622.03502Pr-79

Genes (3)

CD2AP, NFAM1, UBE2V1

Regulons (3)

R-2216, R-1862, R-2507

TGIF1up-regulatesR-25072.17542Pr-79

Genes (3)

CD2AP, NFAM1, UBE2V1

Regulons (3)

R-2216, R-1862, R-2507

HMGA1down-regulatesR-8342.30843Pr-136
KLF13down-regulatesR-2042-2.57211Pr-140

Genes (2)

CALR, ENTPD6

Regulons (4)

R-1157, R-1672, R-2042, R-1823

ETV2down-regulatesR-1507-2.80802Pr-36
ENSG00000162367up-regulatesR-1714-3.26429Pr-130
ZBTB6down-regulatesR-612-3.42389Pr-61
NF1up-regulatesR-124-3.496Pr-36
USF1up-regulatesR-1856-3.72712Pr-64
BORCS8-MEF2Bup-regulatesR-9603.7679Pr-75
POU2F2down-regulatesR-2520-3.9229Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

HMGA1down-regulatesR-829-4.15117Pr-3
HMGA1down-regulatesR-828-4.34589Pr-104
ESRRAdown-regulatesR-2740-4.64571Pr-36

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions