Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

TCF4 - transcription factor 4

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6925 ENSG00000196628 TCF4 A0A1B0GW91

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: TCF4

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
t(11;14)TCF4repressesR-30040.195805Pr-3
t(11;14)_cytogeneticTCF4repressesR-30040.195805Pr-3
BAI3TCF4repressesR-29990.734651Pr-131
FGFR3TCF4repressesR-29990.734651Pr-131
KDM3BTCF4repressesR-29990.734651Pr-131
LTBTCF4repressesR-29990.734651Pr-131
t(11;14)TCF4repressesR-29990.734651Pr-131
RNASeq_FGFR3_CallTCF4repressesR-29990.734651Pr-131
MYCTCF4repressesR-29990.734651Pr-131
t(4;14)TCF4repressesR-29990.734651Pr-131
del13TCF4repressesR-29990.734651Pr-131
t(11;14)_cytogeneticTCF4repressesR-29990.734651Pr-131
t(4;14)_cytogeneticTCF4repressesR-29990.734651Pr-131
NRASTCF4repressesR-30030.851152Pr-139
t(11;14)TCF4repressesR-30030.851152Pr-139
t(11;14)_cytogeneticTCF4repressesR-30030.851152Pr-139
BAI3TCF4activatesR-3000-1.68762Pr-105
FGFR3TCF4activatesR-3000-1.68762Pr-105
KDM3BTCF4activatesR-3000-1.68762Pr-105
t(11;14)TCF4activatesR-3000-1.68762Pr-105
RNASeq_FGFR3_CallTCF4activatesR-3000-1.68762Pr-105
t(4;14)TCF4activatesR-3000-1.68762Pr-105
t(11;14)_cytogeneticTCF4activatesR-3000-1.68762Pr-105
t(4;14)_cytogeneticTCF4activatesR-3000-1.68762Pr-105
NRASTCF4activatesR-3002-3.03869Pr-85
t(11;14)TCF4activatesR-3002-3.03869Pr-85
TRAF3TCF4activatesR-3002-3.03869Pr-85
del13TCF4activatesR-3002-3.03869Pr-85
t(11;14)_cytogeneticTCF4activatesR-3002-3.03869Pr-85
FGFR3TCF4activatesR-29983.92524Pr-75
LTBTCF4activatesR-29983.92524Pr-75
NRASTCF4activatesR-29983.92524Pr-75
t(11;14)TCF4activatesR-29983.92524Pr-75
RNASeq_FGFR3_CallTCF4activatesR-29983.92524Pr-75
t(4;14)TCF4activatesR-29983.92524Pr-75
TRAF3TCF4activatesR-29983.92524Pr-75
del13TCF4activatesR-29983.92524Pr-75
t(11;14)_cytogeneticTCF4activatesR-29983.92524Pr-75
t(4;14)_cytogeneticTCF4activatesR-29983.92524Pr-75
BAI3TCF4activatesR-3001-4.24514Pr-110
CMYA5TCF4activatesR-3001-4.24514Pr-110
FGFR3TCF4activatesR-3001-4.24514Pr-110
KDM3BTCF4activatesR-3001-4.24514Pr-110
KMT2BTCF4activatesR-3001-4.24514Pr-110
LRP2TCF4activatesR-3001-4.24514Pr-110
LTBTCF4activatesR-3001-4.24514Pr-110
NRASTCF4activatesR-3001-4.24514Pr-110
PRKD2TCF4activatesR-3001-4.24514Pr-110
t(11;14)TCF4activatesR-3001-4.24514Pr-110
RNASeq_FGFR3_CallTCF4activatesR-3001-4.24514Pr-110
MYCTCF4activatesR-3001-4.24514Pr-110
t(4;14)TCF4activatesR-3001-4.24514Pr-110
TRAF3TCF4activatesR-3001-4.24514Pr-110
del13TCF4activatesR-3001-4.24514Pr-110
t(11;14)_cytogeneticTCF4activatesR-3001-4.24514Pr-110
t(4;14)_cytogeneticTCF4activatesR-3001-4.24514Pr-110
CMYA5TCF4activatesR-2997-4.26614Pr-17
NRASTCF4activatesR-2997-4.26614Pr-17
TRAF3TCF4activatesR-2997-4.26614Pr-17
del13TCF4activatesR-2997-4.26614Pr-17

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.