Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

HMBOX1 - homeobox containing 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
79618 ENSG00000147421 HMBOX1 E5RHH9

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: HMBOX1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
BAI3HMBOX1activatesR-23820.378178Pr-62
CMYA5HMBOX1activatesR-23820.378178Pr-62
DMDHMBOX1activatesR-23820.378178Pr-62
DNAH5HMBOX1activatesR-23820.378178Pr-62
FGFR3HMBOX1activatesR-23820.378178Pr-62
IRF4HMBOX1activatesR-23820.378178Pr-62
KLHL6HMBOX1activatesR-23820.378178Pr-62
MACF1HMBOX1activatesR-23820.378178Pr-62
MPDZHMBOX1activatesR-23820.378178Pr-62
OBSCNHMBOX1activatesR-23820.378178Pr-62
PCDH10HMBOX1activatesR-23820.378178Pr-62
PKHD1HMBOX1activatesR-23820.378178Pr-62
PKHD1L1HMBOX1activatesR-23820.378178Pr-62
PRDM1HMBOX1activatesR-23820.378178Pr-62
t(11;14)HMBOX1activatesR-23820.378178Pr-62
RNASeq_CCND3_CallHMBOX1activatesR-23820.378178Pr-62
RNASeq_MAFB_CallHMBOX1activatesR-23820.378178Pr-62
SYNE2HMBOX1activatesR-23820.378178Pr-62
TRIOHMBOX1activatesR-23820.378178Pr-62
del17HMBOX1activatesR-23820.378178Pr-62
del17pHMBOX1activatesR-23820.378178Pr-62
t(11;14)_cytogeneticHMBOX1activatesR-23820.378178Pr-62
CMYA5HMBOX1activatesR-2379-0.550956Pr-3
IRF4HMBOX1activatesR-2379-0.550956Pr-3
MACF1HMBOX1activatesR-2379-0.550956Pr-3
PCDH10HMBOX1activatesR-2379-0.550956Pr-3
t(11;14)HMBOX1activatesR-2379-0.550956Pr-3
t(11;14)_cytogeneticHMBOX1activatesR-2379-0.550956Pr-3
FGFR3HMBOX1repressesR-2378-0.732226Pr-41
IRF4HMBOX1repressesR-2378-0.732226Pr-41
t(11;14)HMBOX1repressesR-2378-0.732226Pr-41
RNASeq_MAFB_CallHMBOX1repressesR-2378-0.732226Pr-41
TRIOHMBOX1repressesR-2378-0.732226Pr-41
BAI3HMBOX1repressesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

IRF4HMBOX1repressesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

PKHD1L1HMBOX1repressesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)HMBOX1repressesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_CCND3_CallHMBOX1repressesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)_cytogeneticHMBOX1repressesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

CMYA5HMBOX1activatesR-23851.11927Pr-18
DMDHMBOX1activatesR-23851.11927Pr-18
FGFR3HMBOX1activatesR-23851.11927Pr-18
MACF1HMBOX1activatesR-23851.11927Pr-18
t(11;14)HMBOX1activatesR-23851.11927Pr-18
t(11;14)_cytogeneticHMBOX1activatesR-23851.11927Pr-18
IRF4HMBOX1repressesR-2380-1.45864Pr-105
PKHD1HMBOX1repressesR-2380-1.45864Pr-105
t(11;14)HMBOX1repressesR-2380-1.45864Pr-105
t(11;14)_cytogeneticHMBOX1repressesR-2380-1.45864Pr-105
DMDHMBOX1activatesR-23771.82796Pr-5
FGFR3HMBOX1activatesR-23771.82796Pr-5
PCDH10HMBOX1activatesR-23771.82796Pr-5
PKHD1HMBOX1activatesR-23771.82796Pr-5
t(11;14)HMBOX1activatesR-23771.82796Pr-5
t(11;14)_cytogeneticHMBOX1activatesR-23771.82796Pr-5
DMDHMBOX1activatesR-23813.13315Pr-48
FGFR3HMBOX1activatesR-23813.13315Pr-48
IRF4HMBOX1activatesR-23813.13315Pr-48
RNASeq_MAFB_CallHMBOX1activatesR-23813.13315Pr-48
FGFR3HMBOX1activatesR-23843.45441Pr-50

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.