Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

EGR1 - early growth response 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
1958 ENSG00000120738 EGR1 Q546S1

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: EGR1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
ABCA13EGR1repressesR-2895-0.27249Pr-6
t(11;14)EGR1repressesR-2895-0.27249Pr-6
FGFR3EGR1activatesR-2901-0.911846Pr-20
KDM3BEGR1activatesR-2901-0.911846Pr-20
MAXEGR1activatesR-2901-0.911846Pr-20
RNASeq_FGFR3_CallEGR1activatesR-2901-0.911846Pr-20
t(4;14)EGR1activatesR-2901-0.911846Pr-20
t(4;14)_cytogeneticEGR1activatesR-2901-0.911846Pr-20
DIS3EGR1repressesR-29051.07137Pr-0
MYO10EGR1repressesR-29051.07137Pr-0
t(11;14)EGR1repressesR-29051.07137Pr-0
RNASeq_FGFR3_CallEGR1repressesR-29051.07137Pr-0
t(4;14)EGR1repressesR-29051.07137Pr-0
DIS3EGR1repressesR-28971.44274Pr-87
t(11;14)EGR1repressesR-28971.44274Pr-87
RNASeq_FGFR3_CallEGR1repressesR-28971.44274Pr-87
t(4;14)EGR1repressesR-28971.44274Pr-87
t(4;14)_cytogeneticEGR1repressesR-28971.44274Pr-87
ABCA13EGR1activatesR-2902-2.14629Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(11;14)EGR1activatesR-2902-2.14629Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

DIS3EGR1activatesR-2900-2.27824Pr-39
FGFR3EGR1activatesR-2900-2.27824Pr-39
PRKD2EGR1activatesR-2900-2.27824Pr-39
t(11;14)EGR1activatesR-2900-2.27824Pr-39
RNASeq_FGFR3_CallEGR1activatesR-2900-2.27824Pr-39
t(4;14)EGR1activatesR-2900-2.27824Pr-39
t(4;14)_cytogeneticEGR1activatesR-2900-2.27824Pr-39
FGFR3EGR1activatesR-2896-3.20252Pr-61
MAXEGR1activatesR-2896-3.20252Pr-61
RNASeq_FGFR3_CallEGR1activatesR-2896-3.20252Pr-61
t(4;14)EGR1activatesR-2896-3.20252Pr-61
DIS3EGR1repressesR-28993.63404Pr-18
FGFR3EGR1repressesR-28993.63404Pr-18
PRKD2EGR1repressesR-28993.63404Pr-18
t(11;14)EGR1repressesR-28993.63404Pr-18
RNASeq_FGFR3_CallEGR1repressesR-28993.63404Pr-18
t(4;14)EGR1repressesR-28993.63404Pr-18
t(4;14)_cytogeneticEGR1repressesR-28993.63404Pr-18
DIS3EGR1repressesR-29045.38515Pr-48
FGFR3EGR1repressesR-29045.38515Pr-48
RNASeq_FGFR3_CallEGR1repressesR-29045.38515Pr-48
t(4;14)EGR1repressesR-29045.38515Pr-48
t(4;14)_cytogeneticEGR1repressesR-29045.38515Pr-48

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.