Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ARID3A - AT-rich interaction domain 3A

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
1820 ENSG00000116017 ARID3A K7EJ04

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ARID3A

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2ARID3ArepressesR-13370.134253Pr-5
t(11;14)ARID3ArepressesR-13370.134253Pr-5
t(11;14)ARID3ArepressesR-13420.515151Pr-58
AHNAK2ARID3ArepressesR-1341-0.641665Pr-2
t(11;14)ARID3ArepressesR-1341-0.641665Pr-2
RNASeq_MAFA_CallARID3ArepressesR-1341-0.641665Pr-2
AHNAK2ARID3ArepressesR-1336-0.651462Pr-0
RNASeq_MAFA_CallARID3ArepressesR-1336-0.651462Pr-0
t(11;14)ARID3AactivatesR-13460.725791Pr-120
t(11;14)ARID3ArepressesR-13470.835678Pr-7
AHNAK2ARID3ArepressesR-13400.91304Pr-124
DSTARID3ArepressesR-13400.91304Pr-124
KRASARID3ArepressesR-13400.91304Pr-124
NRASARID3ArepressesR-13400.91304Pr-124
t(11;14)ARID3ArepressesR-13400.91304Pr-124
TRAF3ARID3ArepressesR-13400.91304Pr-124
AHNAK2ARID3ArepressesR-1344-1.15545Pr-9
KRASARID3ArepressesR-1344-1.15545Pr-9
NRASARID3ArepressesR-1344-1.15545Pr-9
t(11;14)ARID3ArepressesR-1344-1.15545Pr-9
RNASeq_MAFA_CallARID3ArepressesR-1344-1.15545Pr-9
TRAF3ARID3ArepressesR-1344-1.15545Pr-9
t(14;16)_cytogeneticARID3ArepressesR-1344-1.15545Pr-9
AHNAK2ARID3ArepressesR-1353-1.16523Pr-10
t(11;14)ARID3ArepressesR-1353-1.16523Pr-10
RNASeq_MAFA_CallARID3ArepressesR-1353-1.16523Pr-10
AHNAK2ARID3ArepressesR-1350-1.27345Pr-5
t(11;14)ARID3ArepressesR-1350-1.27345Pr-5
AHNAK2ARID3AactivatesR-13451.3836Pr-137
DSTARID3AactivatesR-13451.3836Pr-137
t(11;14)ARID3AactivatesR-13451.3836Pr-137
t(11;14)ARID3AactivatesR-1343-1.93899Pr-39
RNASeq_MAFA_CallARID3AactivatesR-1348-2.22043Pr-137
t(14;16)_cytogeneticARID3AactivatesR-1348-2.22043Pr-137
AHNAK2ARID3ArepressesR-13382.23222Pr-60
CYLDARID3ArepressesR-13382.23222Pr-60
DSTARID3ArepressesR-13382.23222Pr-60
KRASARID3ArepressesR-13382.23222Pr-60
t(11;14)ARID3ArepressesR-13382.23222Pr-60
RNASeq_MAFA_CallARID3ArepressesR-13382.23222Pr-60
t(14;16)_cytogeneticARID3ArepressesR-13382.23222Pr-60
t(11;14)ARID3AactivatesR-1355-2.23573Pr-102
NRASARID3ArepressesR-13522.69641Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

OBSCNARID3ArepressesR-13522.69641Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)ARID3ArepressesR-13522.69641Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(14;16)_cytogeneticARID3ArepressesR-13522.69641Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)ARID3AactivatesR-13512.72525Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

RNASeq_MAFA_CallARID3AactivatesR-13512.72525Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

t(14;16)_cytogeneticARID3AactivatesR-13512.72525Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

CYLDARID3ArepressesR-13392.78755Pr-123
t(11;14)ARID3ArepressesR-13392.78755Pr-123
t(11;14)ARID3ArepressesR-13543.07798Pr-60
t(14;16)_cytogeneticARID3ArepressesR-13543.07798Pr-60
NRASARID3AactivatesR-1349-4.86595Pr-110
PRUNE2ARID3AactivatesR-1349-4.86595Pr-110
t(11;14)ARID3AactivatesR-1349-4.86595Pr-110
RNASeq_MAFA_CallARID3AactivatesR-1349-4.86595Pr-110
TRAF3ARID3AactivatesR-1349-4.86595Pr-110

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.