Regulator – Multiple Myeloma Network Portal

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

BORCS8-MEF2B - BORCS8-MEF2B readthrough

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
4207	ENSG00000064489	BORCS8-MEF2B	H3BNR1

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: BORCS8-MEF2B

Mutation	Regulator	Role	Regulon	Cox Hazard Ratio	Transcriptional Program
DIS3	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
DSCAML1	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
FAM46C	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
FRAS1	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
HUWE1	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
IRF4	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
t(11;14)	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
RNASeq_CCND2_Call	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
RNASeq_CCND3_Call	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
del17p	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
t(11;14)_cytogenetic	BORCS8-MEF2B	activates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
t(11;14)	BORCS8-MEF2B	activates	R-961	1.38182	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
RNASeq_CCND2_Call	BORCS8-MEF2B	activates	R-961	1.38182	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
t(11;14)_cytogenetic	BORCS8-MEF2B	activates	R-961	1.38182	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
FRAS1	BORCS8-MEF2B	activates	R-963	2.55553	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
IRF4	BORCS8-MEF2B	activates	R-963	2.55553	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)	BORCS8-MEF2B	activates	R-963	2.55553	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)_cytogenetic	BORCS8-MEF2B	activates	R-963	2.55553	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)	BORCS8-MEF2B	represses	R-962	-3.11327	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
RNASeq_CCND2_Call	BORCS8-MEF2B	represses	R-962	-3.11327	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
SDK1	BORCS8-MEF2B	represses	R-962	-3.11327	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
t(11;14)_cytogenetic	BORCS8-MEF2B	represses	R-962	-3.11327	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
KRAS	BORCS8-MEF2B	represses	R-960	3.7679	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998
t(11;14)	BORCS8-MEF2B	represses	R-960	3.7679	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998
RNASeq_CCND3_Call	BORCS8-MEF2B	represses	R-960	3.7679	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998
RNASeq_MAFA_Call	BORCS8-MEF2B	represses	R-960	3.7679	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998
t(11;14)_cytogenetic	BORCS8-MEF2B	represses	R-960	3.7679	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998

BORCS8-MEF2B - BORCS8-MEF2B readthrough

Causal Mechanistic Flows for Regulator: BORCS8-MEF2B

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Regulator Causal Mechanistic Flow Network