Basic gene annotations are collected from
Uniprot and displayed with links to original sources. A quick link to explore the genomic context with
Uniprot Browser is available.
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a
mutation may causally activate or deactivate a downstream
regulator which then might up- down-regulates a
regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulator:
|Cox Hazard Ratio
mutations (magenta chevrons) to this
regulator (blue triangles) and then from the regulator to the downstream
regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.