Basic gene annotations are collected from
Uniprot and displayed with links to original sources. A quick link to explore the genomic context with
Uniprot Browser is available.
|Entrez ID||EnsEMBL ID||Preferred Name||Uniprot ID|
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a
mutation may causally activate or deactivate a downstream
regulator which then might up- down-regulates a
regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulator:
|Mutation||Regulator||Role||Regulon||Cox Hazard Ratio||Transcriptional Program|
mutations (magenta chevrons) to this
regulator (blue triangles) and then from the regulator to the downstream
regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.