Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ELF3 - E74 like ETS transcription factor 3

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
1999 ENSG00000163435 ELF3 P78545

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ELF3

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
DMDELF3activatesR-21360.0676162Pr-1
TACC2ELF3activatesR-21360.0676162Pr-1
amp1qELF3activatesR-21360.0676162Pr-1
del13ELF3activatesR-21360.0676162Pr-1
del1pELF3activatesR-21360.0676162Pr-1
CMYA5ELF3activatesR-21480.0747421Pr-3
t(11;14)ELF3activatesR-21480.0747421Pr-3
TACC2ELF3activatesR-21480.0747421Pr-3
amp1qELF3activatesR-21480.0747421Pr-3
del13ELF3activatesR-21480.0747421Pr-3
del17ELF3activatesR-21480.0747421Pr-3
del17pELF3activatesR-21480.0747421Pr-3
DCHS1ELF3repressesR-21390.44185Pr-56
FAT3ELF3activatesR-21470.536867Pr-33
KALRNELF3activatesR-21470.536867Pr-33
amp1qELF3activatesR-21470.536867Pr-33
del13ELF3activatesR-21470.536867Pr-33
FAT3ELF3repressesR-2141-0.655011Pr-39
t(11;14)ELF3repressesR-2141-0.655011Pr-39
TACC2ELF3repressesR-2141-0.655011Pr-39
TP53ELF3repressesR-2141-0.655011Pr-39
amp1qELF3repressesR-2141-0.655011Pr-39
del13ELF3repressesR-2141-0.655011Pr-39
del17ELF3repressesR-2141-0.655011Pr-39
t(11;14)ELF3activatesR-21450.727153Pr-7
amp1qELF3activatesR-21450.727153Pr-7
del13ELF3activatesR-21450.727153Pr-7
del1pELF3activatesR-21450.727153Pr-7
FAT3ELF3activatesR-2154-0.760352Pr-12
amp1qELF3activatesR-2154-0.760352Pr-12
del13ELF3activatesR-2154-0.760352Pr-12
CMYA5ELF3activatesR-2151-0.794443Pr-22
TP53ELF3activatesR-2151-0.794443Pr-22
amp1qELF3activatesR-2151-0.794443Pr-22
FAT3ELF3activatesR-2135-0.853767Pr-0
TACC2ELF3activatesR-2135-0.853767Pr-0
amp1qELF3activatesR-2135-0.853767Pr-0
del13ELF3activatesR-2135-0.853767Pr-0
DCHS1ELF3repressesR-2155-0.963705Pr-102
del17ELF3repressesR-2155-0.963705Pr-102
del1pELF3repressesR-2155-0.963705Pr-102
t(11;14)ELF3repressesR-2142-1.2591Pr-117
del13ELF3repressesR-2142-1.2591Pr-117
DCHS1ELF3activatesR-2143-1.40118Pr-9
FAT3ELF3activatesR-2143-1.40118Pr-9
t(11;14)ELF3activatesR-2143-1.40118Pr-9
TACC2ELF3activatesR-2143-1.40118Pr-9
del17ELF3activatesR-2143-1.40118Pr-9
FAT3ELF3activatesR-2153-1.43759Pr-0
KALRNELF3activatesR-2153-1.43759Pr-0
TACC2ELF3activatesR-2153-1.43759Pr-0
amp1qELF3activatesR-2153-1.43759Pr-0
del13ELF3activatesR-2153-1.43759Pr-0
t(11;14)ELF3repressesR-2144-1.50292Pr-37
amp1qELF3repressesR-2144-1.50292Pr-37
del13ELF3repressesR-2144-1.50292Pr-37
CMYA5ELF3repressesR-2140-1.58836Pr-99
t(11;14)ELF3repressesR-2140-1.58836Pr-99
amp1qELF3repressesR-2140-1.58836Pr-99
del13ELF3repressesR-2140-1.58836Pr-99
del17ELF3repressesR-2140-1.58836Pr-99
del17pELF3repressesR-2140-1.58836Pr-99
CMYA5ELF3activatesR-2149-1.67654Pr-10
FAT3ELF3activatesR-2149-1.67654Pr-10
t(11;14)ELF3activatesR-2149-1.67654Pr-10
TACC2ELF3activatesR-2149-1.67654Pr-10
TP53ELF3activatesR-2149-1.67654Pr-10
del17ELF3activatesR-2149-1.67654Pr-10
del17pELF3activatesR-2149-1.67654Pr-10
DCHS1ELF3repressesR-2146-2.09745Pr-89
KALRNELF3repressesR-2146-2.09745Pr-89
t(11;14)ELF3repressesR-2138-2.51196Pr-101
amp1qELF3activatesR-21373.53797Pr-108
del13ELF3activatesR-21373.53797Pr-108
del1pELF3activatesR-21373.53797Pr-108
DMDELF3activatesR-21525.41188Pr-48
amp1qELF3activatesR-21525.41188Pr-48
del13ELF3activatesR-21525.41188Pr-48

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.