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Causal Mechanistic Flows with regulons in program Pr-80

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
DIS3	up-regulates	STAT5A	activates	R-2165	3.50419	11	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
LRP2	down-regulates	STAT5A	activates	R-2165	3.50419	11	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
NEB	down-regulates	STAT5A	activates	R-2165	3.50419	11	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(11;14)	up-regulates	STAT5A	activates	R-2165	3.50419	11	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
del1p	up-regulates	STAT5A	activates	R-2165	3.50419	11	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(11;14)_cytogenetic	up-regulates	STAT5A	activates	R-2165	3.50419	11	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(11;14)	up-regulates	BCL6	activates	R-540	4.65958	20	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(11;14)	up-regulates	FOXP1	activates	R-3133	4.71268	19	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(14;16)	up-regulates	FOXP1	activates	R-3133	4.71268	19	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
amp1q	up-regulates	FOXP1	activates	R-3133	4.71268	19	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
del1p	up-regulates	FOXP1	activates	R-3133	4.71268	19	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
ABCA13	up-regulates	ENSG00000054598	activates	R-1010	5.07904	20	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(11;14)	up-regulates	ENSG00000054598	activates	R-1010	5.07904	20	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
DIS3	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
DNAH10	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
FGFR3	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
KIAA1244	down-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
PRKD2	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(11;14)	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
RNASeq_FGFR3_Call	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(4;14)	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
t(4;14)_cytogenetic	up-regulates	ZBTB16	activates	R-583	5.34764	14	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583

Regulons in program Pr-80

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-2165	3.50419	11	6
R-540	4.65958	20	1
R-3133	4.71268	19	4
R-1010	5.07904	20	2
R-583	5.34764	14	9

Pr-80

Program 80

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Causal Mechanistic Flows with regulons in program Pr-80

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Regulons in program Pr-80

Genes in program Pr-80

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