Program

Causal Mechanistic Flows with regulons in program Pr-66

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
PKHD1L1down-regulatesFOXO3activatesR-2776-0.5544489Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

BRAFup-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

CMYA5down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

CSMD3down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

DIS3up-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

DYNC2H1down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

KIAA1109down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

MACF1down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

MUC16down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

MXRA5down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

PKHD1L1down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

t(11;14)up-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

MYCdown-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

ROBO1down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

TP53down-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

t(11;14)_cytogeneticup-regulatesJUNactivatesR-1184-0.9627388Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

DIS3down-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

MAXdown-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

t(11;14)down-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

RNASeq_CCND3_Calldown-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

RNASeq_MAFB_Calldown-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

t(14;16)down-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

MYCup-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

ROBO1up-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-825-1.4629918Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

Regulons in program Pr-66

Regulon Cox Hazard Ratio # genes # causal flows
R-2776-0.55444891
R-1184-0.962738815
R-825-1.46299189

Genes in program Pr-66

EnsEMBL IdEntrez IdPreferred
ENSG00000182183 348378SHISAL2A
ENSG00000187555 7874USP7
ENSG00000198863 146923RUNDC1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions