Program

Causal Mechanistic Flows with regulons in program Pr-48

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DCHS1up-regulatesENSG00000176887activatesR-19012.89726Pr-48
DIS3up-regulatesENSG00000176887activatesR-19012.89726Pr-48
FAM46Cdown-regulatesENSG00000176887activatesR-19012.89726Pr-48
FGFR3up-regulatesENSG00000176887activatesR-19012.89726Pr-48
LTBup-regulatesENSG00000176887activatesR-19012.89726Pr-48
RNASeq_FGFR3_Callup-regulatesENSG00000176887activatesR-19012.89726Pr-48
t(14;16)up-regulatesENSG00000176887activatesR-19012.89726Pr-48
t(4;14)up-regulatesENSG00000176887activatesR-19012.89726Pr-48
TRIOup-regulatesENSG00000176887activatesR-19012.89726Pr-48
amp1qup-regulatesENSG00000176887activatesR-19012.89726Pr-48
del13up-regulatesENSG00000176887activatesR-19012.89726Pr-48
t(4;14)_cytogeneticup-regulatesENSG00000176887activatesR-19012.89726Pr-48
DIS3up-regulatesTEAD1activatesR-12193.013466Pr-48
FGFR3up-regulatesTEAD1activatesR-12193.013466Pr-48
LTBup-regulatesTEAD1activatesR-12193.013466Pr-48
t(11;14)down-regulatesTEAD1activatesR-12193.013466Pr-48
RNASeq_FGFR3_Callup-regulatesTEAD1activatesR-12193.013466Pr-48
t(4;14)up-regulatesTEAD1activatesR-12193.013466Pr-48
amp1qup-regulatesTEAD1activatesR-12193.013466Pr-48
del13up-regulatesTEAD1activatesR-12193.013466Pr-48
t(11;14)_cytogeneticdown-regulatesTEAD1activatesR-12193.013466Pr-48
t(4;14)_cytogeneticup-regulatesTEAD1activatesR-12193.013466Pr-48
DIS3down-regulatesPAX6repressesR-15583.062386Pr-48
FGFR3down-regulatesPAX6repressesR-15583.062386Pr-48
RNASeq_FGFR3_Calldown-regulatesPAX6repressesR-15583.062386Pr-48
t(14;16)down-regulatesPAX6repressesR-15583.062386Pr-48
t(4;14)down-regulatesPAX6repressesR-15583.062386Pr-48
amp1qdown-regulatesPAX6repressesR-15583.062386Pr-48
del13down-regulatesPAX6repressesR-15583.062386Pr-48
t(4;14)_cytogeneticdown-regulatesPAX6repressesR-15583.062386Pr-48
DMDup-regulatesHMBOX1activatesR-23813.133157Pr-48
FGFR3up-regulatesHMBOX1activatesR-23813.133157Pr-48
IRF4up-regulatesHMBOX1activatesR-23813.133157Pr-48
RNASeq_MAFB_Callup-regulatesHMBOX1activatesR-23813.133157Pr-48
DCHS1up-regulatesENSG00000176887activatesR-18963.135588Pr-48
DIS3up-regulatesENSG00000176887activatesR-18963.135588Pr-48
FGFR3up-regulatesENSG00000176887activatesR-18963.135588Pr-48
LTBup-regulatesENSG00000176887activatesR-18963.135588Pr-48
RNASeq_FGFR3_Callup-regulatesENSG00000176887activatesR-18963.135588Pr-48
t(14;16)up-regulatesENSG00000176887activatesR-18963.135588Pr-48
t(4;14)up-regulatesENSG00000176887activatesR-18963.135588Pr-48
amp1qup-regulatesENSG00000176887activatesR-18963.135588Pr-48
del13up-regulatesENSG00000176887activatesR-18963.135588Pr-48
t(4;14)_cytogeneticup-regulatesENSG00000176887activatesR-18963.135588Pr-48
FGFR3down-regulatesPPARGrepressesR-28293.437256Pr-48
LTBdown-regulatesPPARGrepressesR-28293.437256Pr-48
PCLOdown-regulatesPPARGrepressesR-28293.437256Pr-48
t(11;14)up-regulatesPPARGrepressesR-28293.437256Pr-48
RNASeq_FGFR3_Calldown-regulatesPPARGrepressesR-28293.437256Pr-48
t(14;16)down-regulatesPPARGrepressesR-28293.437256Pr-48
t(4;14)down-regulatesPPARGrepressesR-28293.437256Pr-48
TRAF3down-regulatesPPARGrepressesR-28293.437256Pr-48
amp1qdown-regulatesPPARGrepressesR-28293.437256Pr-48
del13down-regulatesPPARGrepressesR-28293.437256Pr-48
t(14;16)_cytogeneticdown-regulatesPPARGrepressesR-28293.437256Pr-48
ATMup-regulatesSPIBactivatesR-6674.0675117Pr-48
DCHS1up-regulatesSPIBactivatesR-6674.0675117Pr-48
DIS3up-regulatesSPIBactivatesR-6674.0675117Pr-48
OBSCNup-regulatesSPIBactivatesR-6674.0675117Pr-48
RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6674.0675117Pr-48
RNASeq_MAFB_Callup-regulatesSPIBactivatesR-6674.0675117Pr-48
t(14;16)up-regulatesSPIBactivatesR-6674.0675117Pr-48
t(4;14)up-regulatesSPIBactivatesR-6674.0675117Pr-48
amp1qup-regulatesSPIBactivatesR-6674.0675117Pr-48
del13up-regulatesSPIBactivatesR-6674.0675117Pr-48
del1pup-regulatesSPIBactivatesR-6674.0675117Pr-48
t(4;14)_cytogeneticup-regulatesSPIBactivatesR-6674.0675117Pr-48
DCHS1up-regulatesMEF2DactivatesR-8714.185913Pr-48
DIS3up-regulatesMEF2DactivatesR-8714.185913Pr-48
FGFR3up-regulatesMEF2DactivatesR-8714.185913Pr-48
LTBup-regulatesMEF2DactivatesR-8714.185913Pr-48
OBSCNup-regulatesMEF2DactivatesR-8714.185913Pr-48
PCLOup-regulatesMEF2DactivatesR-8714.185913Pr-48
t(11;14)down-regulatesMEF2DactivatesR-8714.185913Pr-48
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8714.185913Pr-48
t(14;16)up-regulatesMEF2DactivatesR-8714.185913Pr-48
t(4;14)up-regulatesMEF2DactivatesR-8714.185913Pr-48
TTNup-regulatesMEF2DactivatesR-8714.185913Pr-48
amp1qup-regulatesMEF2DactivatesR-8714.185913Pr-48
del13up-regulatesMEF2DactivatesR-8714.185913Pr-48
t(14;16)_cytogeneticup-regulatesMEF2DactivatesR-8714.185913Pr-48
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-8714.185913Pr-48
amp1qup-regulatesPOU2F1activatesR-764.3155333Pr-48
del13up-regulatesPOU2F1activatesR-764.3155333Pr-48
DCHS1up-regulatesMAZactivatesR-4984.3661619Pr-48
DIS3up-regulatesMAZactivatesR-4984.3661619Pr-48
FGFR3up-regulatesMAZactivatesR-4984.3661619Pr-48
RELNup-regulatesMAZactivatesR-4984.3661619Pr-48
RNASeq_FGFR3_Callup-regulatesMAZactivatesR-4984.3661619Pr-48
RNASeq_MAFB_Callup-regulatesMAZactivatesR-4984.3661619Pr-48
t(14;16)up-regulatesMAZactivatesR-4984.3661619Pr-48
t(4;14)up-regulatesMAZactivatesR-4984.3661619Pr-48
TRAF3up-regulatesMAZactivatesR-4984.3661619Pr-48
TTNup-regulatesMAZactivatesR-4984.3661619Pr-48
amp1qup-regulatesMAZactivatesR-4984.3661619Pr-48
del13up-regulatesMAZactivatesR-4984.3661619Pr-48
t(14;16)_cytogeneticup-regulatesMAZactivatesR-4984.3661619Pr-48
t(4;14)_cytogeneticup-regulatesMAZactivatesR-4984.3661619Pr-48
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-28854.4430526Pr-48
t(4;14)up-regulatesFOXJ3activatesR-28854.4430526Pr-48
amp1qup-regulatesFOXJ3activatesR-28854.4430526Pr-48
del13up-regulatesFOXJ3activatesR-28854.4430526Pr-48
DMDup-regulatesEWSR1activatesR-25494.47217Pr-48
RNASeq_FGFR3_Callup-regulatesEWSR1activatesR-25494.47217Pr-48
t(14;16)up-regulatesEWSR1activatesR-25494.47217Pr-48
t(4;14)up-regulatesEWSR1activatesR-25494.47217Pr-48
amp1qup-regulatesEWSR1activatesR-25494.47217Pr-48
del13up-regulatesEWSR1activatesR-25494.47217Pr-48
AHNAK2down-regulatesELF1repressesR-29754.7592630Pr-48
NRASup-regulatesELF1repressesR-29754.7592630Pr-48
t(11;14)up-regulatesELF1repressesR-29754.7592630Pr-48
TRAF3down-regulatesELF1repressesR-29754.7592630Pr-48
DIS3up-regulatesPRDM1activatesR-20784.8398716Pr-48
FGFR3up-regulatesPRDM1activatesR-20784.8398716Pr-48
RNASeq_FGFR3_Callup-regulatesPRDM1activatesR-20784.8398716Pr-48
t(14;16)up-regulatesPRDM1activatesR-20784.8398716Pr-48
t(4;14)up-regulatesPRDM1activatesR-20784.8398716Pr-48
amp1qup-regulatesPRDM1activatesR-20784.8398716Pr-48
del13up-regulatesPRDM1activatesR-20784.8398716Pr-48
t(4;14)_cytogeneticup-regulatesPRDM1activatesR-20784.8398716Pr-48
DIS3down-regulatesEGR1repressesR-29045.385156Pr-48
FGFR3down-regulatesEGR1repressesR-29045.385156Pr-48
RNASeq_FGFR3_Calldown-regulatesEGR1repressesR-29045.385156Pr-48
t(4;14)down-regulatesEGR1repressesR-29045.385156Pr-48
t(4;14)_cytogeneticdown-regulatesEGR1repressesR-29045.385156Pr-48
DMDup-regulatesELF3activatesR-21525.411888Pr-48
amp1qup-regulatesELF3activatesR-21525.411888Pr-48
del13up-regulatesELF3activatesR-21525.411888Pr-48
DMDup-regulatesZNF281activatesR-24955.485317Pr-48
RNASeq_FGFR3_Callup-regulatesZNF281activatesR-24955.485317Pr-48
t(4;14)up-regulatesZNF281activatesR-24955.485317Pr-48
amp1qup-regulatesZNF281activatesR-24955.485317Pr-48
del13up-regulatesZNF281activatesR-24955.485317Pr-48

Regulons in program Pr-48

Regulon Cox Hazard Ratio # genes # causal flows
R-19012.8972612
R-12193.01346610
R-15583.0623868
R-23813.1331574
R-18963.13558810
R-28293.43725611
R-6674.067511712
R-8714.18591315
R-764.31553332
R-4984.366161914
R-28854.44305264
R-25494.472176
R-29754.75926304
R-20784.83987168
R-29045.3851565
R-21525.4118883
R-24955.4853175

Genes in program Pr-48

EnsEMBL IdEntrez IdPreferred

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions