Program

Causal Mechanistic Flows with regulons in program Pr-37

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
amp1qup-regulatesELF2repressesR-966-0.25743726Pr-37
del13up-regulatesELF2repressesR-966-0.25743726Pr-37
RNASeq_FGFR3_Callup-regulatesZNF281repressesR-24940.8684527Pr-37
t(4;14)up-regulatesZNF281repressesR-24940.8684527Pr-37
amp1qup-regulatesZNF281repressesR-24940.8684527Pr-37
PCDH15up-regulatesMAFBrepressesR-17470.8937996Pr-37
MYCdown-regulatesMAFBrepressesR-17470.8937996Pr-37
BRAFdown-regulatesGABPAactivatesR-1456-1.0035112Pr-37
IRF4down-regulatesGABPAactivatesR-1456-1.0035112Pr-37
t(11;14)down-regulatesGABPAactivatesR-1456-1.0035112Pr-37
MYCup-regulatesGABPAactivatesR-1456-1.0035112Pr-37
t(4;14)down-regulatesGABPAactivatesR-1456-1.0035112Pr-37
TP53up-regulatesGABPAactivatesR-1456-1.0035112Pr-37
TRAF3down-regulatesGABPAactivatesR-1456-1.0035112Pr-37
amp1qdown-regulatesGABPAactivatesR-1456-1.0035112Pr-37
del13down-regulatesGABPAactivatesR-1456-1.0035112Pr-37
RNASeq_FGFR3_Callup-regulatesETV6repressesR-707-1.2226812Pr-37
t(14;16)up-regulatesETV6repressesR-707-1.2226812Pr-37
t(4;14)up-regulatesETV6repressesR-707-1.2226812Pr-37
amp1qup-regulatesETV6repressesR-707-1.2226812Pr-37
del13up-regulatesETV6repressesR-707-1.2226812Pr-37
t(4;14)_cytogeneticup-regulatesETV6repressesR-707-1.2226812Pr-37
ATMup-regulatesETV6repressesR-698-1.2526516Pr-37
RNASeq_FGFR3_Callup-regulatesETV6repressesR-698-1.2526516Pr-37
RNASeq_MAFB_Callup-regulatesETV6repressesR-698-1.2526516Pr-37
t(14;16)up-regulatesETV6repressesR-698-1.2526516Pr-37
t(4;14)up-regulatesETV6repressesR-698-1.2526516Pr-37
amp1qup-regulatesETV6repressesR-698-1.2526516Pr-37
del13up-regulatesETV6repressesR-698-1.2526516Pr-37
t(4;14)_cytogeneticup-regulatesETV6repressesR-698-1.2526516Pr-37
amp1qup-regulatesELF2repressesR-978-1.3201610Pr-37
del13up-regulatesELF2repressesR-978-1.3201610Pr-37
t(11;14)up-regulatesELK1repressesR-646-1.3952711Pr-37
t(14;16)up-regulatesELK1repressesR-646-1.3952711Pr-37
amp1qup-regulatesELK1repressesR-646-1.3952711Pr-37
del13up-regulatesELK1repressesR-646-1.3952711Pr-37
t(4;14)up-regulatesFOXK1repressesR-1197-1.4390114Pr-37
amp1qup-regulatesFOXK1repressesR-1197-1.4390114Pr-37
del13up-regulatesFOXK1repressesR-1197-1.4390114Pr-37
t(11;14)up-regulatesELF3repressesR-2144-1.5029218Pr-37
amp1qup-regulatesELF3repressesR-2144-1.5029218Pr-37
del13up-regulatesELF3repressesR-2144-1.5029218Pr-37
IRF4down-regulatesGABPAactivatesR-1458-2.327816Pr-37
t(4;14)down-regulatesGABPAactivatesR-1458-2.327816Pr-37
TP53up-regulatesGABPAactivatesR-1458-2.327816Pr-37
amp1qdown-regulatesGABPAactivatesR-1458-2.327816Pr-37
del13down-regulatesGABPAactivatesR-1458-2.327816Pr-37
t(14;16)up-regulatesELK1repressesR-652-2.327816Pr-37
amp1qup-regulatesELK1repressesR-652-2.327816Pr-37
del13up-regulatesELK1repressesR-652-2.327816Pr-37
del1pup-regulatesELK1repressesR-652-2.327816Pr-37
BRAFdown-regulatesPAX6activatesR-1559-2.41876Pr-37
DIS3down-regulatesPAX6activatesR-1559-2.41876Pr-37
FAM46Cup-regulatesPAX6activatesR-1559-2.41876Pr-37
FGFR3down-regulatesPAX6activatesR-1559-2.41876Pr-37
IRF4down-regulatesPAX6activatesR-1559-2.41876Pr-37
PRKD2down-regulatesPAX6activatesR-1559-2.41876Pr-37
t(11;14)down-regulatesPAX6activatesR-1559-2.41876Pr-37
RNASeq_FGFR3_Calldown-regulatesPAX6activatesR-1559-2.41876Pr-37
t(14;16)down-regulatesPAX6activatesR-1559-2.41876Pr-37
t(4;14)down-regulatesPAX6activatesR-1559-2.41876Pr-37
amp1qdown-regulatesPAX6activatesR-1559-2.41876Pr-37
del13down-regulatesPAX6activatesR-1559-2.41876Pr-37
t(11;14)_cytogeneticdown-regulatesPAX6activatesR-1559-2.41876Pr-37
t(4;14)_cytogeneticdown-regulatesPAX6activatesR-1559-2.41876Pr-37
amp1qdown-regulatesNFYCactivatesR-294-3.118579Pr-37
t(11;14)up-regulatesENSG00000054598repressesR-1005-3.2329326Pr-37
HUWE1down-regulatesPKNOX1activatesR-2170-5.073678Pr-37
t(11;14)down-regulatesPKNOX1activatesR-2170-5.073678Pr-37
t(14;16)down-regulatesPKNOX1activatesR-2170-5.073678Pr-37
amp1qdown-regulatesPKNOX1activatesR-2170-5.073678Pr-37
DIS3up-regulatesTGIF1repressesR-2498-5.0985911Pr-37
PRKD2up-regulatesTGIF1repressesR-2498-5.0985911Pr-37
t(11;14)up-regulatesTGIF1repressesR-2498-5.0985911Pr-37
RNASeq_FGFR3_Callup-regulatesTGIF1repressesR-2498-5.0985911Pr-37
t(14;16)up-regulatesTGIF1repressesR-2498-5.0985911Pr-37
t(4;14)up-regulatesTGIF1repressesR-2498-5.0985911Pr-37
t(11;14)_cytogeneticup-regulatesTGIF1repressesR-2498-5.0985911Pr-37
t(4;14)_cytogeneticup-regulatesTGIF1repressesR-2498-5.0985911Pr-37

Regulons in program Pr-37

Regulon Cox Hazard Ratio # genes # causal flows
R-966-0.257437262
R-24940.86845273
R-17470.89379962
R-1456-1.00351129
R-707-1.22268126
R-698-1.25265168
R-978-1.32016102
R-646-1.39527114
R-1197-1.43901143
R-2144-1.50292183
R-1458-2.3278165
R-652-2.3278164
R-1559-2.4187614
R-294-3.1185791
R-1005-3.23293261
R-2170-5.0736784
R-2498-5.09859118

Genes in program Pr-37

EnsEMBL IdEntrez IdPreferred
ENSG00000177692 54943DNAJC28
ENSG00000186329 389177TMEM212
ENSG00000186665 284018C17orf58
ENSG00000188266 123688HYKK
ENSG00000197265 2961GTF2E2
ENSG00000197483 89887ZNF628
ENSG00000198026 63925ZNF335
ENSG00000198642 55958KLHL9
ENSG00000198814 2710GK
ENSG00000198964 259230SGMS1
ENSG00000257704 255783INAFM1
ENSG00000257727 10330CNPY2
ENSG00000272899 100130705LOC100130705

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions