Program

Causal Mechanistic Flows with regulons in program Pr-24

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2up-regulatesPARP1repressesR-26370.34134110Pr-24
PTPRDup-regulatesPARP1repressesR-26370.34134110Pr-24
t(11;14)down-regulatesPARP1repressesR-26370.34134110Pr-24
t(11;14)_cytogeneticdown-regulatesPARP1repressesR-26370.34134110Pr-24
AHNAK2down-regulatesETV6activatesR-7000.40178414Pr-24
ASXL3down-regulatesETV6activatesR-7000.40178414Pr-24
del13up-regulatesETV6activatesR-7000.40178414Pr-24
AHNAK2down-regulatesATF4activatesR-910.98503810Pr-24
NEBdown-regulatesATF4activatesR-910.98503810Pr-24
t(11;14)up-regulatesATF4activatesR-910.98503810Pr-24
SYNE1down-regulatesATF4activatesR-910.98503810Pr-24
amp1qup-regulatesATF4activatesR-910.98503810Pr-24
del13up-regulatesATF4activatesR-910.98503810Pr-24
t(11;14)_cytogeneticup-regulatesATF4activatesR-910.98503810Pr-24
DMDup-regulatesELK4activatesR-7681.078138Pr-24
amp1qup-regulatesELK4activatesR-7681.078138Pr-24
del13up-regulatesELK4activatesR-7681.078138Pr-24
amp1qup-regulatesMEF2AactivatesR-1882-1.2685117Pr-24
AHNAK2down-regulatesFOXP1activatesR-31231.5106431Pr-24
DMDup-regulatesFOXP1activatesR-31231.5106431Pr-24
t(11;14)up-regulatesFOXP1activatesR-31231.5106431Pr-24
amp1qup-regulatesFOXP1activatesR-31231.5106431Pr-24
del13up-regulatesFOXP1activatesR-31231.5106431Pr-24
t(11;14)_cytogeneticup-regulatesFOXP1activatesR-31231.5106431Pr-24
DNAH5down-regulatesHBP1activatesR-18331.7559918Pr-24
NEBdown-regulatesHBP1activatesR-18331.7559918Pr-24
PTPRDdown-regulatesHBP1activatesR-18331.7559918Pr-24
t(11;14)up-regulatesHBP1activatesR-18331.7559918Pr-24
del13up-regulatesHBP1activatesR-18331.7559918Pr-24
DMDup-regulatesETV3activatesR-25332.798748Pr-24
amp1qup-regulatesETV3activatesR-25332.798748Pr-24
del13up-regulatesETV3activatesR-25332.798748Pr-24

Regulons in program Pr-24

Regulon Cox Hazard Ratio # genes # causal flows
R-26370.341341104
R-7000.401784143
R-910.985038107
R-7681.0781383
R-1882-1.26851171
R-31231.51064316
R-18331.75599185
R-25332.7987483

Genes in program Pr-24

EnsEMBL IdEntrez IdPreferred
ENSG00000178971 80169CTC1
ENSG00000179862 163732CITED4
ENSG00000188021 29978UBQLN2
ENSG00000189184
ENSG00000197696 4828NMB
ENSG00000203668 1122CHML
ENSG00000213639 5500PPP1CB

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions