Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation t(11;14)_cytogenetic

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TEAD1down-regulatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

PAX6down-regulatesR-15560.0296134Pr-117
ENSG00000176399up-regulatesR-10720.0376465Pr-105
JUNup-regulatesR-11820.0408673Pr-75
ELK3up-regulatesR-2846-0.0445985Pr-39
USF1up-regulatesR-1855-0.0570761Pr-2
DDIT3up-regulatesR-486-0.0796563Pr-2
IRF1up-regulatesR-180-0.0848453Pr-0
NRF1up-regulatesR-2707-0.0919786Pr-117
ZNF740up-regulatesR-3860.111482Pr-58
XBP1down-regulatesR-30540.128472Pr-3
RFX3up-regulatesR-16660.128531Pr-138
FLI1down-regulatesR-790-0.135687Pr-137
PLAG1down-regulatesR-15220.140759Pr-93
ELF1up-regulatesR-29810.167624Pr-138
ATF4up-regulatesR-920.179335Pr-5
ENSG00000105991down-regulatesR-228-0.185488Pr-3
E4F1up-regulatesR-3147-0.190868Pr-0
TCF4down-regulatesR-30040.195805Pr-3
ATF4up-regulatesR-930.200122Pr-127
THRAup-regulatesR-620.204827Pr-117
HSF2up-regulatesR-3159-0.213586Pr-85
RARAup-regulatesR-161-0.215419Pr-112
NF1up-regulatesR-127-0.22305Pr-18
JUNup-regulatesR-1187-0.237713Pr-12
SOX4down-regulatesR-21870.253475Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

POU2F1up-regulatesR-77-0.259838Pr-14
IRF1up-regulatesR-183-0.261893Pr-2
ELF1up-regulatesR-2977-0.272173Pr-2
POU2F1up-regulatesR-78-0.272418Pr-2
IRF1up-regulatesR-1910.280655Pr-16
FOXJ3up-regulatesR-2876-0.290335Pr-3
PEBP1up-regulatesR-1756-0.29837Pr-58
MAFGup-regulatesR-1490-0.300169Pr-58
ELF1up-regulatesR-2979-0.300753Pr-64
POU2F1up-regulatesR-83-0.310208Pr-41
SF1up-regulatesR-1907-0.317014Pr-3
ZBTB3down-regulatesR-1273-0.320737Pr-111
ZNF281up-regulatesR-24900.3247Pr-3
EWSR1up-regulatesR-25620.325625Pr-5
RARAup-regulatesR-160-0.331894Pr-25
ZNF281up-regulatesR-2479-0.333368Pr-2
TGIF1up-regulatesR-25030.333611Pr-120
CEBPBup-regulatesR-1768-0.337185Pr-109
XBP1down-regulatesR-30590.341163Pr-35
PARP1down-regulatesR-26370.341341Pr-24
HMGA1down-regulatesR-817-0.342996Pr-58
RFX1up-regulatesR-25670.369595Pr-138
ENSG00000176887up-regulatesR-18930.370377Pr-128
PAX6down-regulatesR-1545-0.374773Pr-14
HMBOX1up-regulatesR-23820.378178Pr-62
NF1up-regulatesR-1300.381224Pr-109
CEBPBup-regulatesR-17700.400611Pr-99
SOX4down-regulatesR-2182-0.40215Pr-23
HMGA1down-regulatesR-8320.407077Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

FOXP1up-regulatesR-3121-0.417258Pr-3
ZBTB3down-regulatesR-1275-0.421961Pr-3
HOXA5down-regulatesR-22-0.436928Pr-3
PLAG1down-regulatesR-1516-0.4439Pr-58
ETV2down-regulatesR-15110.447542Pr-62
ENSG00000165066up-regulatesR-30830.448378Pr-99
DR1up-regulatesR-440.451863Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

BDP1down-regulatesR-8410.461691Pr-118
ENSG00000175832up-regulatesR-3140.462821Pr-60
ELF1up-regulatesR-29940.486807Pr-8
RFX3up-regulatesR-1660-0.495816Pr-2
RELup-regulatesR-12780.502416Pr-9
JUNup-regulatesR-11770.50809Pr-138
RFX3up-regulatesR-16770.519248Pr-117
FOXJ3up-regulatesR-2880-0.549489Pr-105
HMBOX1up-regulatesR-2379-0.550956Pr-3
MAFGup-regulatesR-14950.551417Pr-117
FOXP1up-regulatesR-3126-0.555658Pr-2
NR3C1down-regulatesR-3181-0.557618Pr-12
XBP1down-regulatesR-30520.559099Pr-108
ZBTB3down-regulatesR-1272-0.568661Pr-85
IKZF1up-regulatesR-9910.573701Pr-124
IRF4down-regulatesR-490-0.580544Pr-40
ELF1up-regulatesR-2984-0.581395Pr-25
TGIF1up-regulatesR-25010.587545Pr-122
POU2F1up-regulatesR-71-0.58757Pr-3
FOXJ3up-regulatesR-2881-0.590232Pr-34
HOXA3down-regulatesR-226-0.597612Pr-7
ZBTB3down-regulatesR-12700.603274Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

MAFGup-regulatesR-14970.606698Pr-3
STAT1down-regulatesR-3073-0.609623Pr-136
PLAG1down-regulatesR-1520-0.621542Pr-3
ENSG00000168269down-regulatesR-1569-0.622926Pr-54
RUNX3up-regulatesR-901-0.632441Pr-135
SMAD4up-regulatesR-2357-0.642425Pr-60
HSF2up-regulatesR-31670.645152Pr-3
FOXJ3up-regulatesR-2878-0.651802Pr-14
EWSR1up-regulatesR-25590.652492Pr-125
NFYCup-regulatesR-298-0.660463Pr-59
NFATC1up-regulatesR-21970.666306Pr-29
USF1up-regulatesR-18600.671433Pr-21
MEF2Ddown-regulatesR-8770.682478Pr-55
NFATC1up-regulatesR-2201-0.687031Pr-120
NF1up-regulatesR-129-0.687271Pr-55
POU2F1up-regulatesR-720.691442Pr-124
KLF7down-regulatesR-287-0.699278Pr-28
JUNup-regulatesR-11860.700789Pr-75
STAT5Aup-regulatesR-21580.702295Pr-124
PEBP1up-regulatesR-1757-0.714169Pr-41
BORCS8-MEF2Bup-regulatesR-959-0.721458Pr-58
TCF4down-regulatesR-29990.734651Pr-131
KLF13down-regulatesR-2040-0.741584Pr-15
ETV5up-regulatesR-341-0.752701Pr-135
SMAD4up-regulatesR-23560.755167Pr-111
SOX4down-regulatesR-2189-0.776926Pr-12
TGIF1up-regulatesR-2506-0.780236Pr-99
NRF1up-regulatesR-2709-0.785764Pr-99
POU2F2down-regulatesR-2510-0.785808Pr-58
ENSG00000165066up-regulatesR-3078-0.791137Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

POU2F1up-regulatesR-890.796686Pr-18
FLI1down-regulatesR-7920.810335Pr-120
TGIF1up-regulatesR-2504-0.811771Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

NFYCup-regulatesR-3000.814081Pr-130
ELF1up-regulatesR-2995-0.821049Pr-117
TEAD1down-regulatesR-1213-0.831814Pr-58
CEBPBup-regulatesR-1777-0.838666Pr-129
HOXA3down-regulatesR-2210.849107Pr-18
TCF4down-regulatesR-30030.851152Pr-139
USF1up-regulatesR-18540.856068Pr-5
ZBTB16up-regulatesR-578-0.879917Pr-58
RFX1up-regulatesR-25710.881055Pr-7
NF1up-regulatesR-126-0.881056Pr-62
MAFGup-regulatesR-1496-0.904759Pr-101
IRF1up-regulatesR-1820.909345Pr-124
JUNup-regulatesR-11810.916484Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

ENSG00000162367up-regulatesR-17100.916752Pr-126
PITX1down-regulatesR-6600.931027Pr-108
HOXA3down-regulatesR-2230.936261Pr-125
SMAD4up-regulatesR-2353-0.946769Pr-58
JUNup-regulatesR-1184-0.962738Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

NF1up-regulatesR-1280.964935Pr-126
HMBOX1up-regulatesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ENSG00000165066up-regulatesR-30800.967824Pr-131
ELF1up-regulatesR-2974-0.977147Pr-58
ZSCAN16down-regulatesR-630-0.981764Pr-117
FOXO3down-regulatesR-2777-0.982827Pr-27
PAX5up-regulatesR-23740.983647Pr-85
ATF4up-regulatesR-910.985038Pr-24
HMGA1down-regulatesR-821-0.988313Pr-105
ESRRAdown-regulatesR-27380.991373Pr-117
NFATC1up-regulatesR-2207-1.00385Pr-15
ELF1up-regulatesR-29821.00653Pr-58
VENTXup-regulatesR-2116-1.02189Pr-62
ELF1up-regulatesR-29911.02984Pr-117
RFX1up-regulatesR-2572-1.03711Pr-10
CEBPBup-regulatesR-17691.04174Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RARAup-regulatesR-162-1.0531Pr-92
ETV2down-regulatesR-15091.05383Pr-60
HMGA1down-regulatesR-8231.05788Pr-13
MYBup-regulatesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

JUNup-regulatesR-11801.06267Pr-129
HMGA1down-regulatesR-8331.0818Pr-58
FOSup-regulatesR-2190-1.08799Pr-58
SOX4down-regulatesR-2184-1.09056Pr-113
PARP1down-regulatesR-2642-1.09441Pr-99
PITX1down-regulatesR-657-1.09874Pr-58
ENSG00000168269down-regulatesR-15631.10269Pr-62
JUNup-regulatesR-11781.10274Pr-13
NFE2L2up-regulatesR-1914-1.10423Pr-125
NFE2L1up-regulatesR-18241.11096Pr-127
HMBOX1up-regulatesR-23851.11927Pr-18
FOXP1up-regulatesR-3141-1.12635Pr-3
FOXJ3up-regulatesR-28841.12637Pr-16
POU2F1up-regulatesR-67-1.13734Pr-58
FOXJ3up-regulatesR-2871-1.14551Pr-58
ZBTB16up-regulatesR-587-1.14633Pr-99
MAFGup-regulatesR-1485-1.14909Pr-117
MZF1down-regulatesR-30161.15326Pr-5
PATZ1up-regulatesR-2195-1.15328Pr-58
NFATC1up-regulatesR-2204-1.15799Pr-10
KLF7down-regulatesR-282-1.16094Pr-15
STAT3down-regulatesR-3101.16096Pr-93
NR3C1down-regulatesR-31831.16931Pr-13
POU2F1up-regulatesR-841.16934Pr-16
RFX3up-regulatesR-1673-1.17273Pr-10
ESRRAdown-regulatesR-27461.17735Pr-72
POU2F2down-regulatesR-25151.18037Pr-18
SMAD3up-regulatesR-29611.18119Pr-117
RUNX3up-regulatesR-903-1.18553Pr-10
THRAup-regulatesR-581.19237Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

RARAup-regulatesR-1571.1957Pr-117
ZNF219up-regulatesR-2217-1.20137Pr-10
HMGA1down-regulatesR-836-1.21151Pr-3
ENSG00000165066up-regulatesR-3076-1.21549Pr-58
FOXP1up-regulatesR-31311.21746Pr-93
PLAG1down-regulatesR-15171.22016Pr-108
PAX6down-regulatesR-15551.22022Pr-135
HMGA1down-regulatesR-827-1.23916Pr-3
RARAup-regulatesR-1641.24046Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

EWSR1up-regulatesR-2561-1.24127Pr-6
HMGA1down-regulatesR-8261.24266Pr-93
MAFGup-regulatesR-1491-1.24402Pr-112
ENSG00000136574down-regulatesR-391.25412Pr-124
IRF1up-regulatesR-1941.26041Pr-3
ATF2up-regulatesR-30921.26346Pr-111
ENSG00000168269down-regulatesR-15641.28019Pr-59
CREB3L2down-regulatesR-521-1.29128Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

FOXP1up-regulatesR-31281.29587Pr-16
KLF13down-regulatesR-2041-1.31925Pr-42
ZNF219up-regulatesR-22161.32424Pr-79

Genes (3)

CD2AP, NFAM1, UBE2V1

Regulons (3)

R-2216, R-1862, R-2507

ATF2up-regulatesR-30911.32566Pr-41
IRF4down-regulatesR-492-1.32725Pr-99
HOXD1down-regulatesR-13031.32893Pr-131
NF1up-regulatesR-125-1.32934Pr-118
HSF4up-regulatesR-174-1.34961Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

RARAup-regulatesR-1481.3622Pr-5
POU2F1up-regulatesR-81-1.36714Pr-105
POU2F2down-regulatesR-25121.37817Pr-62
BORCS8-MEF2Bup-regulatesR-9611.38182Pr-62
ENSG00000176887up-regulatesR-1891-1.3829Pr-99
RARAup-regulatesR-1631.38439Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ZEB1down-regulatesR-2242-1.38529Pr-12
DR1up-regulatesR-421.38624Pr-5
XBP1down-regulatesR-3063-1.39137Pr-99
BACH1up-regulatesR-472-1.40118Pr-138
NR2C2down-regulatesR-1390-1.41324Pr-118
MLXdown-regulatesR-31981.41369Pr-5
ESRRAdown-regulatesR-2737-1.42424Pr-15
FLI1down-regulatesR-789-1.43137Pr-19
RFX1up-regulatesR-2570-1.43236Pr-9
TGIF1up-regulatesR-25021.43548Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ZNF740up-regulatesR-395-1.44318Pr-28
SMAD3up-regulatesR-29631.44668Pr-120
EWSR1up-regulatesR-2553-1.45023Pr-0
HMBOX1up-regulatesR-2380-1.45864Pr-105
FOXJ3up-regulatesR-2892-1.46097Pr-10
ZEB1down-regulatesR-22501.46262Pr-52
HMGA1down-regulatesR-825-1.46299Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

ENSG00000176887up-regulatesR-18941.46342Pr-58
STAT5Aup-regulatesR-2162-1.47979Pr-99
NR2F6down-regulatesR-13781.48043Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

MAFdown-regulatesR-1041.49044Pr-88
MZF1down-regulatesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

XBP1down-regulatesR-3064-1.49068Pr-2
SMAD4up-regulatesR-23581.49431Pr-117
HOXA3down-regulatesR-2271.49853Pr-38
JUNup-regulatesR-1179-1.50896Pr-129
FOXP1up-regulatesR-31231.51064Pr-24
SMAD4up-regulatesR-23591.51133Pr-125
STAT1down-regulatesR-3070-1.51615Pr-99
FOXJ3up-regulatesR-28881.53881Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

KLF7down-regulatesR-281-1.54497Pr-12
PAX6down-regulatesR-15441.54726Pr-87
ZBTB3down-regulatesR-12711.5513Pr-117
PAX5up-regulatesR-23761.56155Pr-87
ZNF219up-regulatesR-2211-1.56166Pr-86
IRF1up-regulatesR-188-1.56891Pr-99
RARAup-regulatesR-1651.59669Pr-18
MYBup-regulatesR-6171.6152Pr-87
FOSup-regulatesR-2192-1.63051Pr-118
MAFGup-regulatesR-14891.63202Pr-117
ENSG00000168269down-regulatesR-1566-1.63414Pr-65
ZBTB16up-regulatesR-581-1.64909Pr-5
ZBTB16up-regulatesR-582-1.65525Pr-105
HOXA3down-regulatesR-224-1.66402Pr-103
NR3C1down-regulatesR-3194-1.67228Pr-27
ZNF281up-regulatesR-2491-1.68427Pr-10
RFX3up-regulatesR-16571.68517Pr-60
TCF4down-regulatesR-3000-1.68762Pr-105
RARAup-regulatesR-1561.71471Pr-16
ZBTB4up-regulatesR-20901.72041Pr-117
ESRRAdown-regulatesR-27411.72748Pr-125
RFX7down-regulatesR-2750-1.73199Pr-118
KLF16down-regulatesR-2698-1.7325Pr-28
FOXP1up-regulatesR-3129-1.73747Pr-99
ATF5up-regulatesR-2404-1.7554Pr-136
RARAup-regulatesR-155-1.76335Pr-42
ENSG00000165066up-regulatesR-30841.77633Pr-137
ENSG00000087510down-regulatesR-2631-1.77831Pr-130
ZNF281up-regulatesR-24731.77923Pr-5
ZNF350up-regulatesR-30281.79292Pr-8
HMGA1down-regulatesR-8201.79517Pr-87
ZBTB16up-regulatesR-5861.81277Pr-3
ESRRAdown-regulatesR-27361.82545Pr-60
HMBOX1up-regulatesR-23771.82796Pr-5
POU2F2down-regulatesR-2517-1.83475Pr-113
BDP1down-regulatesR-842-1.83917Pr-118
KLF7down-regulatesR-289-1.856Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ATF2up-regulatesR-30931.86649Pr-139
PAX6down-regulatesR-15571.87661Pr-71
NRF1up-regulatesR-27051.91369Pr-136
TGIF1up-regulatesR-2505-1.93918Pr-109
ENSG00000165066up-regulatesR-30791.94606Pr-13
NRF1up-regulatesR-27041.94607Pr-117
CEBPBup-regulatesR-1763-1.95423Pr-103
STAT1down-regulatesR-3072-1.97892Pr-43

Genes (1)

C14orf132

Regulons (3)

R-3072, R-2745, R-608

ZNF740up-regulatesR-3841.98118Pr-52
SMAD3up-regulatesR-2967-1.98807Pr-139
IRF1up-regulatesR-1962.01864Pr-108
TEAD1down-regulatesR-1215-2.0223Pr-3
PLAG1down-regulatesR-1521-2.02883Pr-118
USF1up-regulatesR-18622.03502Pr-79

Genes (3)

CD2AP, NFAM1, UBE2V1

Regulons (3)

R-2216, R-1862, R-2507

RFX3up-regulatesR-16752.03925Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

PLAG1down-regulatesR-1530-2.05356Pr-61
NR3C1down-regulatesR-31792.06628Pr-60
EWSR1up-regulatesR-25472.07792Pr-125
ZEB1down-regulatesR-2243-2.08616Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

E4F1up-regulatesR-3148-2.09252Pr-58
PLAG1down-regulatesR-1525-2.09931Pr-42
RUNX3up-regulatesR-8922.10284Pr-125
NFYCup-regulatesR-297-2.11334Pr-15
CEBPBup-regulatesR-17762.1174Pr-139
ESRRAdown-regulatesR-27392.13083Pr-126
NR3C1down-regulatesR-3195-2.141Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

ZNF219up-regulatesR-22122.14665Pr-139
STAT3down-regulatesR-306-2.15021Pr-90
ESRRAdown-regulatesR-27442.16113Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

RUNX3up-regulatesR-896-2.16669Pr-91
RELup-regulatesR-12792.17366Pr-16
TGIF1up-regulatesR-25072.17542Pr-79

Genes (3)

CD2AP, NFAM1, UBE2V1

Regulons (3)

R-2216, R-1862, R-2507

ZNF219up-regulatesR-22192.18386Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

CEBPBup-regulatesR-1766-2.18542Pr-126
KLF16down-regulatesR-2694-2.18545Pr-118
FLI1down-regulatesR-7842.19671Pr-137
BDP1down-regulatesR-840-2.21467Pr-101
ELF1up-regulatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

ZNF281up-regulatesR-24762.2168Pr-125
KLF7down-regulatesR-284-2.22134Pr-11
IKZF1up-regulatesR-9962.22566Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

ZNF740up-regulatesR-397-2.24578Pr-139
SMAD3up-regulatesR-29652.28284Pr-137
MZF1down-regulatesR-30212.2875Pr-87
HMGA1down-regulatesR-8342.30843Pr-136
NR2C2down-regulatesR-13872.31271Pr-131
MAFdown-regulatesR-1032.31568Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RUNX2up-regulatesR-12832.3191Pr-123
MZF1down-regulatesR-3022-2.32297Pr-139
NR2F6down-regulatesR-13752.34002Pr-123
ZNF281up-regulatesR-2482-2.34579Pr-30
SOX4down-regulatesR-2183-2.35721Pr-59
NR3C1down-regulatesR-3187-2.36326Pr-85
RARAup-regulatesR-167-2.36681Pr-3
EWSR1up-regulatesR-25602.38471Pr-82

Genes (2)

ZBED5

Regulons (3)

R-2436, R-2560, R-963

XBP1down-regulatesR-3056-2.38499Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

PATZ1up-regulatesR-21962.39409Pr-55
ZBTB16up-regulatesR-5932.41668Pr-124
PAX6down-regulatesR-1559-2.4187Pr-37
ZBTB16up-regulatesR-588-2.42313Pr-10
PLAG1down-regulatesR-15242.46239Pr-139
RUNX3up-regulatesR-8972.4661Pr-108
CEBPBup-regulatesR-17602.49135Pr-73
ENSG00000162367up-regulatesR-17152.49892Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FOXO3down-regulatesR-2767-2.51658Pr-4
ENSG00000168269down-regulatesR-15712.51736Pr-136
ZNF281up-regulatesR-2481-2.52054Pr-103
BORCS8-MEF2Bup-regulatesR-9632.55553Pr-82

Genes (2)

ZBED5

Regulons (3)

R-2436, R-2560, R-963

IKZF1up-regulatesR-990-2.55623Pr-4
ETV2down-regulatesR-15082.5634Pr-59
MZF1down-regulatesR-30202.57034Pr-8
KLF13down-regulatesR-2042-2.57211Pr-140

Genes (2)

CALR, ENTPD6

Regulons (4)

R-1157, R-1672, R-2042, R-1823

KLF16down-regulatesR-2702-2.58138Pr-89
BRCA1up-regulatesR-1033-2.58375Pr-12
PAX6down-regulatesR-15472.58661Pr-123
ZBTB7Bdown-regulatesR-12332.59774Pr-52
NR3C1down-regulatesR-3196-2.61331Pr-101
ENSG00000176887up-regulatesR-1898-2.61611Pr-36
RUNX2up-regulatesR-12842.62887Pr-108
RARAup-regulatesR-151-2.63142Pr-61
HMGA1down-regulatesR-830-2.65695Pr-109
PLAG1down-regulatesR-15182.66482Pr-108
RARAup-regulatesR-158-2.69255Pr-38
BRCA1up-regulatesR-10312.71498Pr-123
RUNX3up-regulatesR-8982.74094Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

RFX7down-regulatesR-2751-2.75742Pr-136
ELF1up-regulatesR-2988-2.78126Pr-39
FOSup-regulatesR-2191-2.78131Pr-15
ENSG00000162367up-regulatesR-17062.80624Pr-123
ETV2down-regulatesR-1507-2.80802Pr-36
IRF1up-regulatesR-1852.8096Pr-123
HSF4up-regulatesR-1732.83222Pr-73
RFX3up-regulatesR-1664-2.83731Pr-103
ZBTB16up-regulatesR-584-2.83773Pr-38
NR3C1down-regulatesR-3182-2.83908Pr-101
TFEBup-regulatesR-887-2.83976Pr-64
JUNup-regulatesR-11832.84299Pr-128
HOXA5down-regulatesR-25-2.84707Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

ENSG00000105991down-regulatesR-229-2.84707Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

HMGA1down-regulatesR-835-2.84969Pr-112
NRF1up-regulatesR-27032.85746Pr-72
ENSG00000175832up-regulatesR-313-2.85877Pr-101
HMGA1down-regulatesR-819-2.87568Pr-100
ATF4up-regulatesR-95-2.89504Pr-10
HOXA5down-regulatesR-232.9056Pr-123
RARAup-regulatesR-154-2.90748Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

JUNup-regulatesR-1176-2.91332Pr-94
RFX3up-regulatesR-16612.92167Pr-52
MEF2Ddown-regulatesR-8682.92774Pr-108
BACH1up-regulatesR-4762.9321Pr-21
SOX4down-regulatesR-21772.93862Pr-108
ENSG00000087510down-regulatesR-26292.94655Pr-52
KLF16down-regulatesR-2693-2.95355Pr-86
FOXO3down-regulatesR-2772-2.97174Pr-11
ZBTB7Bdown-regulatesR-1232-2.98559Pr-35
EWSR1up-regulatesR-2552-2.99469Pr-39
FLI1down-regulatesR-787-3.00169Pr-118
TEAD1down-regulatesR-12193.01346Pr-48
EWSR1up-regulatesR-25433.03243Pr-126
PARP1down-regulatesR-26383.03283Pr-126
TCF4down-regulatesR-3002-3.03869Pr-85
ETV5up-regulatesR-340-3.04337Pr-36
PITX1down-regulatesR-658-3.04345Pr-59
FLI1down-regulatesR-7813.05111Pr-73
PITX1down-regulatesR-659-3.05142Pr-38
IRF1up-regulatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

ENSG00000175832up-regulatesR-312-3.06Pr-36
STAT5Aup-regulatesR-2161-3.07199Pr-101
BACH1up-regulatesR-475-3.0829Pr-103
HSF2up-regulatesR-31603.09147Pr-8
STAT5Aup-regulatesR-21683.10259Pr-122
E2F7up-regulatesR-13853.10364Pr-5
BORCS8-MEF2Bup-regulatesR-962-3.11327Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

ZNF219up-regulatesR-2213-3.11551Pr-118
FLI1down-regulatesR-780-3.11957Pr-36
POU2F2down-regulatesR-2519-3.13355Pr-104
MYBup-regulatesR-6163.1672Pr-123
RARAup-regulatesR-153-3.1944Pr-61
IRF1up-regulatesR-1813.21843Pr-8
SOX4down-regulatesR-2188-3.25506Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

POU2F1up-regulatesR-753.2562Pr-8
ENSG00000162367up-regulatesR-1714-3.26429Pr-130
ZBTB16up-regulatesR-591-3.27441Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

KLF16down-regulatesR-2689-3.29428Pr-118
CEBPBup-regulatesR-1761-3.29826Pr-100
FOXO3down-regulatesR-2771-3.30433Pr-100
ENSG00000165066up-regulatesR-30773.31834Pr-52
ESRRAdown-regulatesR-2745-3.32726Pr-43

Genes (1)

C14orf132

Regulons (3)

R-3072, R-2745, R-608

ENSG00000165066up-regulatesR-30823.32738Pr-63
ZBTB16up-regulatesR-592-3.36768Pr-112
FOXO3down-regulatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

NFE2L2up-regulatesR-19123.38406Pr-75
PEBP1up-regulatesR-1752-3.39081Pr-36
ZEB1down-regulatesR-2241-3.39487Pr-11
DLX4down-regulatesR-19863.40059Pr-52
CEBPBup-regulatesR-1773-3.41393Pr-109
MZF1down-regulatesR-3019-3.42244Pr-35
ZBTB6down-regulatesR-612-3.42389Pr-61
ENSG00000176887up-regulatesR-18923.42989Pr-122
RFX3up-regulatesR-16623.44658Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

BRCA1up-regulatesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

ESRRAdown-regulatesR-2743-3.48448Pr-86
ZEB1down-regulatesR-2253-3.48803Pr-86
NF1up-regulatesR-124-3.496Pr-36
STAT5Aup-regulatesR-21653.50419Pr-80

Genes (0)

Regulons (5)

R-2165, R-540, R-3133, R-1010, R-583

POU2F2down-regulatesR-2511-3.52119Pr-100
ZBTB3down-regulatesR-1269-3.55836Pr-135
VDRdown-regulatesR-1229-3.57357Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

STAT3down-regulatesR-3053.59519Pr-52
ENSG00000176887up-regulatesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

STAT3down-regulatesR-307-3.61941Pr-11
MZF1down-regulatesR-3023-3.63658Pr-103
TEAD1down-regulatesR-12163.63699Pr-108
POU2F2down-regulatesR-2513-3.64661Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

USF1up-regulatesR-1856-3.72712Pr-64
ENSG00000165066up-regulatesR-30813.73477Pr-128
PLAG1down-regulatesR-15273.7556Pr-54
BORCS8-MEF2Bup-regulatesR-9603.7679Pr-75
ELF1up-regulatesR-29783.77589Pr-52
CEBPBup-regulatesR-1775-3.79192Pr-36
NFYCup-regulatesR-2963.81355Pr-70
MEF2Ddown-regulatesR-8703.82168Pr-52
KLF16down-regulatesR-2691-3.83169Pr-35
FOX3Adown-regulatesR-15143.87415Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

EWSR1up-regulatesR-25563.89633Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

TEAD1down-regulatesR-1218-3.91201Pr-112
ZNF281up-regulatesR-2484-3.91355Pr-20
POU2F2down-regulatesR-2520-3.9229Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

CEBPBup-regulatesR-1774-3.92486Pr-38
TCF4down-regulatesR-29983.92524Pr-75
NR3C1down-regulatesR-3191-3.95197Pr-104
RARAup-regulatesR-170-3.98886Pr-109
FOX3Adown-regulatesR-15123.9913Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

CEBPBup-regulatesR-17724.02047Pr-122
PAX5up-regulatesR-2375-4.04335Pr-61
HOXA3down-regulatesR-2254.12962Pr-128
HMGA1down-regulatesR-829-4.15117Pr-3
KLF16down-regulatesR-2692-4.15636Pr-100
TCF4down-regulatesR-3001-4.24514Pr-110
MYBup-regulatesR-626-4.24578Pr-36
ZNF219up-regulatesR-22144.26397Pr-63
KLF16down-regulatesR-2700-4.30129Pr-42
NR2F6down-regulatesR-1379-4.31321Pr-118
POU2F1up-regulatesR-884.3225Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

KLF7down-regulatesR-280-4.33884Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

HMGA1down-regulatesR-828-4.34589Pr-104
NR2F6down-regulatesR-1381-4.38369Pr-42
ELF1up-regulatesR-2980-4.39203Pr-61
NR3C1down-regulatesR-3184-4.39801Pr-110
PLAG1down-regulatesR-1526-4.47157Pr-11
FLI1down-regulatesR-794-4.49758Pr-36
NRF1up-regulatesR-27104.52843Pr-72
RFX3up-regulatesR-16654.55866Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RARAup-regulatesR-168-4.56773Pr-36
ESRRAdown-regulatesR-2740-4.64571Pr-36
ENSG00000136574down-regulatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RFX3up-regulatesR-16714.70938Pr-18
ENSG00000168269down-regulatesR-1567-4.76751Pr-36
ZNF219up-regulatesR-2215-4.80967Pr-104
POU2F1up-regulatesR-864.85124Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

TGIF1up-regulatesR-2498-5.09859Pr-37
POU2F2down-regulatesR-2516-5.21606Pr-38
SREBF1up-regulatesR-1138-5.22607Pr-104
MYBup-regulatesR-621-5.47246Pr-104
FOSup-regulatesR-21945.48447Pr-63
PLAG1down-regulatesR-1529-5.51479Pr-61
NFATC1up-regulatesR-2199-5.63196Pr-135
EWSR1up-regulatesR-2545-5.82984Pr-36
PLAG1down-regulatesR-1523-6.09323Pr-135
FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RARAup-regulatesR-1526.62924Pr-71
FOXP1up-regulatesR-31226.78787Pr-71
KLF7down-regulatesR-2837.07253Pr-68
FOXJ3up-regulatesR-28757.15409Pr-71
ENSG00000176399up-regulatesR-10717.79759Pr-71

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions

no survival information available