Mutation – Multiple Myeloma Network Portal

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation DNAH10

Regulator	Role	Regulon	Cox Hazard Ratio (Regulon)	Transcriptional Programs
RREB1	down-regulates	R-2304	-0.103823	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
VENTX	up-regulates	R-2117	0.118548	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ELF1	up-regulates	R-2981	0.167624	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
ZBTB16	up-regulates	R-589	0.185533	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
SPIB	up-regulates	R-670	-0.26844	Pr-92 Genes (9) SVBP, AKAP5, SLC25A42, HDDC3, ZNRF1, ZNF197, TMEM222, FAM120AOS Regulons (9) R-670, R-1389, R-1063, R-2294, R-1012, R-1938, R-209, R-2697, R-162
ELF4	up-regulates	R-2349	0.277486	Pr-33 Genes (6) ZNF620, IMPDH2, SLC35C1, TIGIT, AP2A2, C11orf96 Regulons (6) R-1415, R-2349, R-2893, R-2147, R-1014, R-2205
ENSG00000162367	up-regulates	R-1711	0.576626	Pr-8 Genes (12) F2R, NPLOC4, COA5, TMEM17, MESP2, SLC29A3, CPNE1, RBM14, ADSL, CNTF, MRPL46, SRXN1 Regulons (25) R-2994, R-1711, R-449, R-2248, R-1649, R-1658, R-3028, R-2489, R-1433, R-94, R-632, R-2548, R-3020, R-3006, R-2051, R-233, R-3160, R-665, R-181, R-75, R-2633, R-2210, R-2434, R-1060, R-230
TGIF1	up-regulates	R-2501	0.587545	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
CEBPE	up-regulates	R-2684	0.76264	Pr-88 Genes (14) GADD45GIP1, PAK2, D2HGDH, AEN, DHTKD1, KBTBD3, RPS27L, CD47, ZNF587, SFMBT2, DCLRE1A, TCTN1, MEF2B Regulons (16) R-900, R-491, R-893, R-102, R-1247, R-2627, R-2234, R-2684, R-3138, R-368, R-2620, R-104, R-1690, R-1206, R-3142, R-2660
ELF1	up-regulates	R-2995	-0.821049	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
STAT4	up-regulates	R-2659	-0.852357	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
IRF1	up-regulates	R-182	0.909345	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
ENSG00000162367	up-regulates	R-1710	0.916752	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
FOXO3	down-regulates	R-2777	-0.982827	Pr-27 Genes (8) AGMO, CALHM6, NHLRC2, DNM3, ITSN1, PLPP6 Regulons (8) R-2493, R-2777, R-1790, R-2323, R-2279, R-2558, R-2815, R-3194
SRF	down-regulates	R-1790	-1.04379	Pr-27 Genes (8) AGMO, CALHM6, NHLRC2, DNM3, ITSN1, PLPP6 Regulons (8) R-2493, R-2777, R-1790, R-2323, R-2279, R-2558, R-2815, R-3194
TGIF1	up-regulates	R-2500	1.06891	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
SPIB	up-regulates	R-671	1.40228	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
TGIF1	up-regulates	R-2502	1.43548	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
NR2F6	down-regulates	R-1378	1.48043	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
SRF	down-regulates	R-1784	1.54282	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
BHLHE40	up-regulates	R-943	1.64543	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
SRF	down-regulates	R-1788	-1.83514	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
ELF4	up-regulates	R-2339	1.84468	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
MAZ	up-regulates	R-495	1.8487	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
MZF1	down-regulates	R-3027	1.86359	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
E2F2	up-regulates	R-2945	1.88745	Pr-133 Genes (6) UCP3, GJD4, ACOT4, HNRNPA0, ZCWPW2 Regulons (7) R-3071, R-1940, R-2231, R-372, R-2200, R-2945, R-2989
IRF1	up-regulates	R-196	2.01864	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
RUNX3	up-regulates	R-892	2.10284	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
YY1	up-regulates	R-2523	-2.28203	Pr-107 Genes (3) HIST4H4, BRK1, OCLM Regulons (4) R-521, R-2523, R-3056, R-154
NR2C2	down-regulates	R-1387	2.31271	Pr-131 Genes (6) UBE2G2, ERC2, SLC9A8, ZNF770, MGEA5, ZNF350 Regulons (6) R-2999, R-3080, R-706, R-1303, R-79, R-1387
RUNX2	up-regulates	R-1283	2.3191	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
MZF1	down-regulates	R-3022	-2.32297	Pr-139 Genes (11) MRFAP1, PRKRA, BAZ1A, FAM72D, LHX4-AS1, ZNF709, TMEM35B, ATXN7L3B, NFIA Regulons (11) R-2364, R-2807, R-3003, R-3009, R-3093, R-2967, R-1776, R-2212, R-397, R-3022, R-1524
SPIB	up-regulates	R-669	2.43375	Pr-32 Genes (4) ATP5MF-PTCD1, ZNF674, TRIM34, ATF1 Regulons (6) R-1645, R-1550, R-1309, R-669, R-1280, R-2762
RREB1	down-regulates	R-2289	-2.4348	Pr-94 Genes (3) NPW, C8orf88, KLF16 Regulons (8) R-1852, R-1282, R-2289, R-1176, R-3180, R-357, R-1402, R-1428
RUNX3	up-regulates	R-897	2.4661	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
ENSG00000176887	up-regulates	R-1898	-2.61611	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
RUNX2	up-regulates	R-1284	2.62887	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
BRCA1	up-regulates	R-1031	2.71498	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
RUNX3	up-regulates	R-898	2.74094	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
ENSG00000162367	up-regulates	R-1706	2.80624	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
IRF1	up-regulates	R-185	2.8096	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
ELF4	up-regulates	R-2348	-2.83012	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
RFX3	up-regulates	R-1664	-2.83731	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
ENSG00000175832	up-regulates	R-313	-2.85877	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
MAZ	up-regulates	R-513	-2.96542	Pr-44 Genes (0) Regulons (7) R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280
SPIB	up-regulates	R-676	-3.00251	Pr-112 Genes (5) CD19, COMMD6, MRPL21, IPP, FAM228B Regulons (10) R-161, R-1838, R-3036, R-1491, R-2275, R-835, R-676, R-1746, R-592, R-1218
STAT5B	up-regulates	R-2367	3.00488	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
IRF1	up-regulates	R-197	3.05156	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
ENSG00000175832	up-regulates	R-312	-3.06	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
SPIB	up-regulates	R-665	3.11837	Pr-8 Genes (12) F2R, NPLOC4, COA5, TMEM17, MESP2, SLC29A3, CPNE1, RBM14, ADSL, CNTF, MRPL46, SRXN1 Regulons (25) R-2994, R-1711, R-449, R-2248, R-1649, R-1658, R-3028, R-2489, R-1433, R-94, R-632, R-2548, R-3020, R-3006, R-2051, R-233, R-3160, R-665, R-181, R-75, R-2633, R-2210, R-2434, R-1060, R-230
STAT5B	up-regulates	R-2368	-3.16004	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
ENSG00000162367	up-regulates	R-1712	3.18381	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
MZF1	down-regulates	R-3018	-3.24499	Pr-44 Genes (0) Regulons (7) R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280
ENSG00000162367	up-regulates	R-1714	-3.26429	Pr-130 Genes (6) ULK1, AURKB, ACTL10, ZFP36L1, PEAK3, IRF9 Regulons (8) R-373, R-2661, R-565, R-300, R-1080, R-2631, R-1714, R-1407
ZBTB16	up-regulates	R-591	-3.27441	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
FOXO3	down-regulates	R-2771	-3.30433	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
SPIB	up-regulates	R-678	3.32159	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
FOXO3	down-regulates	R-2773	-3.37313	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
ENSG00000176887	up-regulates	R-1892	3.42989	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
BRCA1	up-regulates	R-1030	-3.4552	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
SPIB	up-regulates	R-680	3.46117	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
IRF1	up-regulates	R-179	3.48115	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
STAT5B	up-regulates	R-2370	3.57469	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
STAT4	up-regulates	R-2650	3.59414	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
FOXM1	up-regulates	R-1443	3.59968	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
MZF1	down-regulates	R-3023	-3.63658	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
YY1	up-regulates	R-2525	3.91807	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
MAZ	up-regulates	R-509	-4.01621	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
NFIA	up-regulates	R-355	4.10051	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
RREB1	down-regulates	R-2287	-4.14495	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
CEBPE	up-regulates	R-2686	4.15069	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
NR2F6	down-regulates	R-1381	-4.38369	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
ELF1	up-regulates	R-2980	-4.39203	Pr-61 Genes (2) HLA-DQA1, SCARF2 Regulons (13) R-1530, R-2176, R-151, R-637, R-153, R-2896, R-612, R-909, R-2375, R-1414, R-2980, R-653, R-1529
STAT4	up-regulates	R-2653	4.54157	Pr-114 Genes (3) PCGF5, SAMD11, KCTD21 Regulons (7) R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107
SRF	down-regulates	R-1785	4.55548	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
MAZ	up-regulates	R-506	-4.85353	Pr-4 Genes (37) B3GNT4, ZNF575, CRACR2B, ALS2CL, TCAIM, MED14, ADO, SFXN4, TM2D3, GAS2L1, EIF4EBP1, COL4A5, LRRK2, MXD3, ZBED8, CFAP97D1, WDR92, TMEM141, USP51, ZNF260, MTRNR2L8, CLLU1, CHURC1, CEP95, MRPL12, RPS10-NUDT3, YY1, BACH2, E2F2 Regulons (47) R-295, R-2879, R-2639, R-2318, R-3043, R-1908, R-1695, R-1554, R-2485, R-1767, R-777, R-443, R-1753, R-2114, R-1585, R-2824, R-1670, R-560, R-293, R-773, R-2432, R-270, R-2099, R-778, R-1778, R-1633, R-1277, R-1463, R-818, R-176, R-1573, R-1468, R-2599, R-2799, R-68, R-2950, R-2767, R-1174, R-990, R-2658, R-2221, R-2487, R-1684, R-3051, R-2813, R-1017, R-506
SRF	down-regulates	R-1787	-5.29074	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
ENSG00000102678	up-regulates	R-232	5.31311	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
ZBTB16	up-regulates	R-583	5.34764	Pr-80 Genes (0) Regulons (5) R-2165, R-540, R-3133, R-1010, R-583
SRF	down-regulates	R-1780	7.20867	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
E2F2	up-regulates	R-2942	8.59906	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F8	up-regulates	R-1626	8.62493	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F2	up-regulates	R-2944	8.90615	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F8	up-regulates	R-1627	9.26408	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627

Causal Mechanistic Flows for Mutation DNAH10

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