List of causal flows influenced by the mutation.
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Mutation
| Regulator | Role | Regulon | Cox Hazard Ratio (Regulon) | Transcriptional Programs |
|---|
Mutation Causal Mechanistic Flow Network
Cytoscape network of the causal flows influenced by the mutation.
Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.
