Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

FOXK1 - forkhead box K1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
221937 ENSG00000164916 FOXK1 P85037

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: FOXK1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
t(4;14)FOXK1activatesR-11950.153559Pr-7
amp1qFOXK1activatesR-11950.153559Pr-7
del13FOXK1activatesR-11950.153559Pr-7
AHNAK2FOXK1activatesR-1207-0.237776Pr-5
FAT3FOXK1activatesR-1207-0.237776Pr-5
KALRNFOXK1activatesR-1207-0.237776Pr-5
MACF1FOXK1activatesR-1207-0.237776Pr-5
MAGI1FOXK1activatesR-1207-0.237776Pr-5
MYO10FOXK1activatesR-1207-0.237776Pr-5
NEBFOXK1activatesR-1207-0.237776Pr-5
PTPRDFOXK1activatesR-1207-0.237776Pr-5
t(4;14)FOXK1activatesR-1207-0.237776Pr-5
TACC2FOXK1activatesR-1207-0.237776Pr-5
amp1qFOXK1activatesR-1207-0.237776Pr-5
del13FOXK1activatesR-1207-0.237776Pr-5
AHNAK2FOXK1activatesR-1191-0.320198Pr-3
MACF1FOXK1activatesR-1191-0.320198Pr-3
MAGI1FOXK1activatesR-1191-0.320198Pr-3
MYO10FOXK1activatesR-1191-0.320198Pr-3
NEBFOXK1activatesR-1191-0.320198Pr-3
RNASeq_MAFA_CallFOXK1activatesR-1191-0.320198Pr-3
SYNE1FOXK1activatesR-1191-0.320198Pr-3
TACC2FOXK1activatesR-1191-0.320198Pr-3
del13FOXK1activatesR-1191-0.320198Pr-3
AHNAK2FOXK1repressesR-12000.353655Pr-128
RNASeq_MAFA_CallFOXK1repressesR-12000.353655Pr-128
AHNAK2FOXK1activatesR-1192-0.353736Pr-0
ASXL3FOXK1activatesR-1192-0.353736Pr-0
MAGI1FOXK1activatesR-1192-0.353736Pr-0
MYO10FOXK1activatesR-1192-0.353736Pr-0
NEBFOXK1activatesR-1192-0.353736Pr-0
PTPRDFOXK1activatesR-1192-0.353736Pr-0
RNASeq_MAFA_CallFOXK1activatesR-1192-0.353736Pr-0
t(4;14)FOXK1activatesR-1192-0.353736Pr-0
SYNE1FOXK1activatesR-1192-0.353736Pr-0
TACC2FOXK1activatesR-1192-0.353736Pr-0
amp1qFOXK1activatesR-1192-0.353736Pr-0
del13FOXK1activatesR-1192-0.353736Pr-0
ASXL3FOXK1activatesR-11900.433468Pr-1
MAGI1FOXK1activatesR-11900.433468Pr-1
NEBFOXK1activatesR-11900.433468Pr-1
TACC2FOXK1activatesR-11900.433468Pr-1
amp1qFOXK1activatesR-11900.433468Pr-1
del13FOXK1activatesR-11900.433468Pr-1
AHNAK2FOXK1repressesR-1212-0.459405Pr-99
DCHS1FOXK1repressesR-1212-0.459405Pr-99
FAT3FOXK1repressesR-1212-0.459405Pr-99
MYO10FOXK1repressesR-1212-0.459405Pr-99
NEBFOXK1repressesR-1212-0.459405Pr-99
TACC2FOXK1repressesR-1212-0.459405Pr-99
del13FOXK1repressesR-1212-0.459405Pr-99
AHNAK2FOXK1activatesR-1188-0.824193Pr-0
ASXL3FOXK1activatesR-1188-0.824193Pr-0
DCHS1FOXK1activatesR-1188-0.824193Pr-0
FAT3FOXK1activatesR-1188-0.824193Pr-0
KALRNFOXK1activatesR-1188-0.824193Pr-0
MACF1FOXK1activatesR-1188-0.824193Pr-0
MAGI1FOXK1activatesR-1188-0.824193Pr-0
MYO10FOXK1activatesR-1188-0.824193Pr-0
NEBFOXK1activatesR-1188-0.824193Pr-0
PTPRDFOXK1activatesR-1188-0.824193Pr-0
RNASeq_MAFA_CallFOXK1activatesR-1188-0.824193Pr-0
SYNE1FOXK1activatesR-1188-0.824193Pr-0
TACC2FOXK1activatesR-1188-0.824193Pr-0
amp1qFOXK1activatesR-1188-0.824193Pr-0
del13FOXK1activatesR-1188-0.824193Pr-0
AHNAK2FOXK1activatesR-1198-0.848863Pr-5
FAT3FOXK1activatesR-1198-0.848863Pr-5
TACC2FOXK1activatesR-1198-0.848863Pr-5
amp1qFOXK1activatesR-1198-0.848863Pr-5
del13FOXK1activatesR-1198-0.848863Pr-5
AHNAK2FOXK1activatesR-1189-1.15299Pr-2
FAT3FOXK1activatesR-1189-1.15299Pr-2
MACF1FOXK1activatesR-1189-1.15299Pr-2
PTPRDFOXK1activatesR-1189-1.15299Pr-2
t(4;14)FOXK1activatesR-1189-1.15299Pr-2
SYNE1FOXK1activatesR-1189-1.15299Pr-2
TACC2FOXK1activatesR-1189-1.15299Pr-2
amp1qFOXK1activatesR-1189-1.15299Pr-2
del13FOXK1activatesR-1189-1.15299Pr-2
amp1qFOXK1activatesR-12091.17225Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

del13FOXK1activatesR-12091.17225Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

NEBFOXK1repressesR-1211-1.32195Pr-91
t(4;14)FOXK1repressesR-1211-1.32195Pr-91
t(4;14)FOXK1repressesR-1197-1.43901Pr-37
amp1qFOXK1repressesR-1197-1.43901Pr-37
del13FOXK1repressesR-1197-1.43901Pr-37
AHNAK2FOXK1activatesR-1205-1.46171Pr-10
FAT3FOXK1activatesR-1205-1.46171Pr-10
MACF1FOXK1activatesR-1205-1.46171Pr-10
RNASeq_MAFA_CallFOXK1activatesR-1205-1.46171Pr-10
t(4;14)FOXK1activatesR-1205-1.46171Pr-10
TACC2FOXK1activatesR-1205-1.46171Pr-10
PTPRDFOXK1activatesR-1203-1.63258Pr-113
t(4;14)FOXK1activatesR-1203-1.63258Pr-113
amp1qFOXK1activatesR-1203-1.63258Pr-113
del13FOXK1activatesR-1203-1.63258Pr-113
KALRNFOXK1repressesR-1206-1.77991Pr-88
RNASeq_MAFA_CallFOXK1repressesR-1206-1.77991Pr-88
t(4;14)FOXK1repressesR-1206-1.77991Pr-88
del13FOXK1repressesR-1206-1.77991Pr-88
t(4;14)FOXK1repressesR-12081.86976Pr-63
amp1qFOXK1repressesR-12081.86976Pr-63
del13FOXK1repressesR-12081.86976Pr-63
AHNAK2FOXK1activatesR-1202-1.92921Pr-28
ASXL3FOXK1activatesR-1202-1.92921Pr-28
TACC2FOXK1activatesR-1202-1.92921Pr-28
amp1qFOXK1activatesR-1202-1.92921Pr-28
del13FOXK1activatesR-1202-1.92921Pr-28
AHNAK2FOXK1activatesR-1194-2.1796Pr-17
FAT3FOXK1activatesR-1194-2.1796Pr-17
amp1qFOXK1activatesR-1194-2.1796Pr-17
del13FOXK1activatesR-1194-2.1796Pr-17
RNASeq_MAFA_CallFOXK1activatesR-1193-2.56141Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

AHNAK2FOXK1activatesR-1201-2.93735Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

PTPRDFOXK1activatesR-1201-2.93735Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_MAFA_CallFOXK1activatesR-1201-2.93735Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(4;14)FOXK1activatesR-1201-2.93735Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

SYNE1FOXK1activatesR-1201-2.93735Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

DCHS1FOXK1activatesR-12043.06585Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

FAT3FOXK1activatesR-12043.06585Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

MAGI1FOXK1activatesR-12043.06585Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

RNASeq_MAFA_CallFOXK1activatesR-12043.06585Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

AHNAK2FOXK1repressesR-12103.29949Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

DCHS1FOXK1repressesR-12103.29949Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

PTPRDFOXK1repressesR-12103.29949Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

RNASeq_MAFA_CallFOXK1repressesR-12103.29949Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

AHNAK2FOXK1activatesR-1196-3.80774Pr-11
ASXL3FOXK1activatesR-1196-3.80774Pr-11
FAT3FOXK1activatesR-1196-3.80774Pr-11
KALRNFOXK1activatesR-1196-3.80774Pr-11
PTPRDFOXK1activatesR-1196-3.80774Pr-11
t(4;14)FOXK1activatesR-1196-3.80774Pr-11
SYNE1FOXK1activatesR-1196-3.80774Pr-11
TACC2FOXK1activatesR-1196-3.80774Pr-11
amp1qFOXK1activatesR-1196-3.80774Pr-11
del13FOXK1activatesR-1196-3.80774Pr-11

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.