Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

RREB1 - ras responsive element binding protein 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6239 ENSG00000124782 RREB1 C9JE09

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: RREB1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
DNAH10RREB1repressesR-2304-0.103823Pr-135
MACF1RREB1repressesR-2304-0.103823Pr-135
MXRA5RREB1repressesR-2304-0.103823Pr-135
RNASeq_MAFA_CallRREB1repressesR-2304-0.103823Pr-135
TP53RREB1repressesR-2304-0.103823Pr-135
CMYA5RREB1repressesR-22990.160797Pr-120
TP53RREB1repressesR-22990.160797Pr-120
AHNAK2RREB1activatesR-2284-0.436433Pr-14
t(4;14)RREB1activatesR-2284-0.436433Pr-14
SETD2RREB1activatesR-2284-0.436433Pr-14
SYNE1RREB1activatesR-2284-0.436433Pr-14
TP53RREB1activatesR-2284-0.436433Pr-14
RNASeq_FGFR3_CallRREB1activatesR-2294-0.502089Pr-92
t(4;14)RREB1activatesR-2294-0.502089Pr-92
t(4;14)_cytogeneticRREB1activatesR-2294-0.502089Pr-92
AHNAK2RREB1activatesR-2285-0.538758Pr-3
CMYA5RREB1activatesR-2285-0.538758Pr-3
MACF1RREB1activatesR-2285-0.538758Pr-3
RNASeq_MAFB_CallRREB1activatesR-2285-0.538758Pr-3
SYNE1RREB1activatesR-2285-0.538758Pr-3
TACC2RREB1activatesR-2285-0.538758Pr-3
AHNAK2RREB1activatesR-2283-0.618728Pr-2
CMYA5RREB1activatesR-2283-0.618728Pr-2
MACF1RREB1activatesR-2283-0.618728Pr-2
RNASeq_MAFA_CallRREB1activatesR-2283-0.618728Pr-2
RNASeq_MAFB_CallRREB1activatesR-2283-0.618728Pr-2
SYNE1RREB1activatesR-2283-0.618728Pr-2
TACC2RREB1activatesR-2283-0.618728Pr-2
AHNAK2RREB1activatesR-2300-0.646333Pr-20
MACF1RREB1activatesR-2300-0.646333Pr-20
RNASeq_FGFR3_CallRREB1activatesR-2300-0.646333Pr-20
RNASeq_MAFA_CallRREB1activatesR-2300-0.646333Pr-20
RNASeq_MAFB_CallRREB1activatesR-2300-0.646333Pr-20
t(4;14)RREB1activatesR-2300-0.646333Pr-20
TACC2RREB1activatesR-2300-0.646333Pr-20
t(4;14)_cytogeneticRREB1activatesR-2300-0.646333Pr-20
AHNAK2RREB1activatesR-2296-0.757232Pr-9
CMYA5RREB1activatesR-2296-0.757232Pr-9
FAT3RREB1activatesR-2296-0.757232Pr-9
KDM3BRREB1activatesR-2296-0.757232Pr-9
MACF1RREB1activatesR-2296-0.757232Pr-9
RNASeq_FGFR3_CallRREB1activatesR-2296-0.757232Pr-9
RNASeq_MAFA_CallRREB1activatesR-2296-0.757232Pr-9
RNASeq_MAFB_CallRREB1activatesR-2296-0.757232Pr-9
t(4;14)RREB1activatesR-2296-0.757232Pr-9
SETD2RREB1activatesR-2296-0.757232Pr-9
TACC2RREB1activatesR-2296-0.757232Pr-9
t(4;14)_cytogeneticRREB1activatesR-2296-0.757232Pr-9
TP53RREB1repressesR-2293-0.862205Pr-135
AHNAK2RREB1repressesR-23011.03902Pr-59
AHNAK2RREB1activatesR-2298-1.11227Pr-6
PRKD2RREB1activatesR-2298-1.11227Pr-6
RNASeq_MAFA_CallRREB1activatesR-2298-1.11227Pr-6
TACC2RREB1activatesR-2298-1.11227Pr-6
TP53RREB1activatesR-2298-1.11227Pr-6
AHNAK2RREB1activatesR-22901.22484Pr-16
FAT3RREB1activatesR-22901.22484Pr-16
TACC2RREB1activatesR-22901.22484Pr-16
KDM3BRREB1activatesR-2305-1.52832Pr-0
TACC2RREB1activatesR-2305-1.52832Pr-0
ZNF462RREB1activatesR-2305-1.52832Pr-0
AHNAK2RREB1activatesR-22821.60852Pr-5
TACC2RREB1activatesR-22821.60852Pr-5
KDM3BRREB1activatesR-2291-1.6207Pr-12
MXRA5RREB1activatesR-2291-1.6207Pr-12
SYNE1RREB1activatesR-2291-1.6207Pr-12
TP53RREB1activatesR-2291-1.6207Pr-12
ZNF462RREB1activatesR-2291-1.6207Pr-12
KDM3BRREB1activatesR-2303-1.65549Pr-113
RNASeq_MAFB_CallRREB1activatesR-2303-1.65549Pr-113
ZNF462RREB1activatesR-2303-1.65549Pr-113
AHNAK2RREB1activatesR-2302-1.95334Pr-10
CMYA5RREB1activatesR-2302-1.95334Pr-10
MACF1RREB1activatesR-2302-1.95334Pr-10
RNASeq_MAFA_CallRREB1activatesR-2302-1.95334Pr-10
TACC2RREB1activatesR-2302-1.95334Pr-10
TP53RREB1activatesR-2302-1.95334Pr-10
AHNAK2RREB1activatesR-2286-2.31249Pr-17
CMYA5RREB1activatesR-2286-2.31249Pr-17
FAT3RREB1activatesR-2286-2.31249Pr-17
MXRA5RREB1activatesR-2286-2.31249Pr-17
TACC2RREB1activatesR-2286-2.31249Pr-17
TP53RREB1activatesR-2286-2.31249Pr-17
CMYA5RREB1activatesR-2289-2.4348Pr-94
DNAH10RREB1activatesR-2289-2.4348Pr-94
MXRA5RREB1activatesR-2289-2.4348Pr-94
PRKD2RREB1activatesR-2289-2.4348Pr-94
RNASeq_FGFR3_CallRREB1activatesR-2289-2.4348Pr-94
t(4;14)RREB1activatesR-2289-2.4348Pr-94
TP53RREB1activatesR-2289-2.4348Pr-94
AHNAK2RREB1activatesR-2297-2.5711Pr-20
CMYA5RREB1activatesR-2297-2.5711Pr-20
FAT3RREB1activatesR-2297-2.5711Pr-20
RNASeq_FGFR3_CallRREB1activatesR-2297-2.5711Pr-20
RNASeq_MAFB_CallRREB1activatesR-2297-2.5711Pr-20
t(4;14)RREB1activatesR-2297-2.5711Pr-20
t(4;14)_cytogeneticRREB1activatesR-2297-2.5711Pr-20
FAT3RREB1activatesR-2288-3.12172Pr-15
RNASeq_FGFR3_CallRREB1activatesR-2288-3.12172Pr-15
t(4;14)RREB1activatesR-2288-3.12172Pr-15
t(4;14)_cytogeneticRREB1activatesR-2288-3.12172Pr-15
FAT3RREB1activatesR-2292-3.46394Pr-101
PRKD2RREB1activatesR-2292-3.46394Pr-101
RNASeq_FGFR3_CallRREB1activatesR-2292-3.46394Pr-101
RNASeq_MAFA_CallRREB1activatesR-2292-3.46394Pr-101
RNASeq_MAFB_CallRREB1activatesR-2292-3.46394Pr-101
t(4;14)RREB1activatesR-2292-3.46394Pr-101
SETD2RREB1activatesR-2292-3.46394Pr-101
TP53RREB1activatesR-2292-3.46394Pr-101
t(4;14)_cytogeneticRREB1activatesR-2292-3.46394Pr-101
AHNAK2RREB1activatesR-2287-4.14495Pr-100
DNAH10RREB1activatesR-2287-4.14495Pr-100
PRKD2RREB1activatesR-2287-4.14495Pr-100
RNASeq_FGFR3_CallRREB1activatesR-2287-4.14495Pr-100
RNASeq_MAFA_CallRREB1activatesR-2287-4.14495Pr-100
t(4;14)RREB1activatesR-2287-4.14495Pr-100
SETD2RREB1activatesR-2287-4.14495Pr-100
TP53RREB1activatesR-2287-4.14495Pr-100
t(4;14)_cytogeneticRREB1activatesR-2287-4.14495Pr-100
AHNAK2RREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FAT3RREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MACF1RREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_FGFR3_CallRREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_MAFA_CallRREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_MAFB_CallRREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)RREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SETD2RREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

TTNRREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ZNF462RREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)_cytogeneticRREB1repressesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.