Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ELF1 - E74 like ETS transcription factor 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
1997 ENSG00000120690 ELF1 A0A0D9SG85

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ELF1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
DNAH10ELF1repressesR-29810.167624Pr-138
PRDM1ELF1repressesR-29810.167624Pr-138
t(11;14)ELF1repressesR-29810.167624Pr-138
TRAF3ELF1repressesR-29810.167624Pr-138
t(11;14)_cytogeneticELF1repressesR-29810.167624Pr-138
AHNAK2ELF1activatesR-2977-0.272173Pr-2
PCDH10ELF1activatesR-2977-0.272173Pr-2
t(11;14)ELF1activatesR-2977-0.272173Pr-2
t(11;14)_cytogeneticELF1activatesR-2977-0.272173Pr-2
AHNAK2ELF1activatesR-2979-0.300753Pr-64
DSTELF1activatesR-2979-0.300753Pr-64
PCDH10ELF1activatesR-2979-0.300753Pr-64
t(11;14)ELF1activatesR-2979-0.300753Pr-64
t(11;14)_cytogeneticELF1activatesR-2979-0.300753Pr-64
t(11;14)ELF1activatesR-29940.486807Pr-8
t(11;14)_cytogeneticELF1activatesR-29940.486807Pr-8
AHNAK2ELF1activatesR-2984-0.581395Pr-25
NRASELF1activatesR-2984-0.581395Pr-25
t(11;14)ELF1activatesR-2984-0.581395Pr-25
TRAF3ELF1activatesR-2984-0.581395Pr-25
t(11;14)_cytogeneticELF1activatesR-2984-0.581395Pr-25
AHNAK2ELF1repressesR-2995-0.821049Pr-117
DNAH10ELF1repressesR-2995-0.821049Pr-117
KRASELF1repressesR-2995-0.821049Pr-117
NRASELF1repressesR-2995-0.821049Pr-117
t(11;14)ELF1repressesR-2995-0.821049Pr-117
TRAF3ELF1repressesR-2995-0.821049Pr-117
t(11;14)_cytogeneticELF1repressesR-2995-0.821049Pr-117
DSTELF1activatesR-2974-0.977147Pr-58
PCDH10ELF1activatesR-2974-0.977147Pr-58
t(11;14)ELF1activatesR-2974-0.977147Pr-58
t(11;14)_cytogeneticELF1activatesR-2974-0.977147Pr-58
DSTELF1activatesR-29821.00653Pr-58
KRASELF1activatesR-29821.00653Pr-58
t(11;14)ELF1activatesR-29821.00653Pr-58
t(11;14)_cytogeneticELF1activatesR-29821.00653Pr-58
t(11;14)ELF1repressesR-29911.02984Pr-117
t(11;14)_cytogeneticELF1repressesR-29911.02984Pr-117
TRAF3ELF1activatesR-2996-1.04319Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(11;14)ELF1repressesR-29851.28146Pr-135
DSTELF1activatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

NRASELF1activatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(11;14)ELF1activatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

TRAF3ELF1activatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(11;14)_cytogeneticELF1activatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

KIAA1244ELF1repressesR-2988-2.78126Pr-39
t(11;14)ELF1repressesR-2988-2.78126Pr-39
t(11;14)_cytogeneticELF1repressesR-2988-2.78126Pr-39
AHNAK2ELF1repressesR-29892.94799Pr-133
NRASELF1repressesR-29892.94799Pr-133
AHNAK2ELF1repressesR-29862.98171Pr-74
DSTELF1repressesR-29862.98171Pr-74
TRAF3ELF1repressesR-29862.98171Pr-74
t(11;14)ELF1repressesR-29933.17759Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

AHNAK2ELF1repressesR-29783.77589Pr-52
DSTELF1repressesR-29783.77589Pr-52
NRASELF1repressesR-29783.77589Pr-52
t(11;14)ELF1repressesR-29783.77589Pr-52
TRAF3ELF1repressesR-29783.77589Pr-52
t(11;14)_cytogeneticELF1repressesR-29783.77589Pr-52
AHNAK2ELF1repressesR-29834.09607Pr-50
NRASELF1repressesR-29834.09607Pr-50
t(11;14)ELF1repressesR-29834.09607Pr-50
TRAF3ELF1repressesR-29834.09607Pr-50
AHNAK2ELF1repressesR-29764.38806Pr-70
BAI3ELF1repressesR-29764.38806Pr-70
TRAF3ELF1repressesR-29764.38806Pr-70
AHNAK2ELF1activatesR-2980-4.39203Pr-61
DNAH10ELF1activatesR-2980-4.39203Pr-61
DSTELF1activatesR-2980-4.39203Pr-61
t(11;14)ELF1activatesR-2980-4.39203Pr-61
t(11;14)_cytogeneticELF1activatesR-2980-4.39203Pr-61
AHNAK2ELF1repressesR-29754.75926Pr-48
NRASELF1repressesR-29754.75926Pr-48
t(11;14)ELF1repressesR-29754.75926Pr-48
TRAF3ELF1repressesR-29754.75926Pr-48
AHNAK2ELF1repressesR-29925.06585Pr-70
PCDH10ELF1repressesR-29925.06585Pr-70

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.