Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

MZF1 - myeloid zinc finger 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
7593 ENSG00000099326 MZF1 M0R2C0

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: MZF1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
t(11;14)MZF1repressesR-3015-1.00106Pr-0
amp1qMZF1repressesR-3015-1.00106Pr-0
del13MZF1repressesR-3015-1.00106Pr-0
DIS3MZF1repressesR-30161.15326Pr-5
FGFR3MZF1repressesR-30161.15326Pr-5
IRF4MZF1repressesR-30161.15326Pr-5
LTBMZF1repressesR-30161.15326Pr-5
t(11;14)MZF1repressesR-30161.15326Pr-5
RNASeq_FGFR3_CallMZF1repressesR-30161.15326Pr-5
t(14;16)MZF1repressesR-30161.15326Pr-5
t(4;14)MZF1repressesR-30161.15326Pr-5
amp1qMZF1repressesR-30161.15326Pr-5
del13MZF1repressesR-30161.15326Pr-5
t(11;14)_cytogeneticMZF1repressesR-30161.15326Pr-5
t(4;14)_cytogeneticMZF1repressesR-30161.15326Pr-5
BRAFMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

DCHS1MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

DIS3MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

FAT3MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

IRF4MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

NRASMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RELNMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

RNASeq_MAFA_CallMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(14;16)MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

amp1qMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

del13MZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(11;14)_cytogeneticMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

t(14;16)_cytogeneticMZF1repressesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

DCHS1MZF1repressesR-30171.54275Pr-85
DIS3MZF1repressesR-30171.54275Pr-85
FAM46CMZF1repressesR-30171.54275Pr-85
NRASMZF1repressesR-30171.54275Pr-85
RELNMZF1repressesR-30171.54275Pr-85
RNASeq_MAFA_CallMZF1repressesR-30171.54275Pr-85
t(14;16)MZF1repressesR-30171.54275Pr-85
t(4;14)MZF1repressesR-30171.54275Pr-85
TRIOMZF1repressesR-30171.54275Pr-85
amp1qMZF1repressesR-30171.54275Pr-85
del13MZF1repressesR-30171.54275Pr-85
t(14;16)_cytogeneticMZF1repressesR-30171.54275Pr-85
t(4;14)_cytogeneticMZF1repressesR-30171.54275Pr-85
NRASMZF1repressesR-3025-1.67565Pr-11
RNASeq_FGFR3_CallMZF1repressesR-3025-1.67565Pr-11
RNASeq_MAFA_CallMZF1repressesR-3025-1.67565Pr-11
t(14;16)MZF1repressesR-3025-1.67565Pr-11
t(4;14)MZF1repressesR-3025-1.67565Pr-11
amp1qMZF1repressesR-3025-1.67565Pr-11
del13MZF1repressesR-3025-1.67565Pr-11
t(14;16)_cytogeneticMZF1repressesR-3025-1.67565Pr-11
t(4;14)_cytogeneticMZF1repressesR-3025-1.67565Pr-11
CYLDMZF1repressesR-30271.86359Pr-108
DIS3MZF1repressesR-30271.86359Pr-108
DNAH10MZF1repressesR-30271.86359Pr-108
FGFR3MZF1repressesR-30271.86359Pr-108
LTBMZF1repressesR-30271.86359Pr-108
MPDZMZF1repressesR-30271.86359Pr-108
NRASMZF1repressesR-30271.86359Pr-108
PRKD2MZF1repressesR-30271.86359Pr-108
RNASeq_FGFR3_CallMZF1repressesR-30271.86359Pr-108
t(4;14)MZF1repressesR-30271.86359Pr-108
ROBO1MZF1repressesR-30271.86359Pr-108
amp1qMZF1repressesR-30271.86359Pr-108
del13MZF1repressesR-30271.86359Pr-108
t(4;14)_cytogeneticMZF1repressesR-30271.86359Pr-108
BRAFMZF1repressesR-30212.2875Pr-87
DCHS1MZF1repressesR-30212.2875Pr-87
DIS3MZF1repressesR-30212.2875Pr-87
FAM46CMZF1repressesR-30212.2875Pr-87
IRF4MZF1repressesR-30212.2875Pr-87
NRASMZF1repressesR-30212.2875Pr-87
t(11;14)MZF1repressesR-30212.2875Pr-87
RNASeq_MAFA_CallMZF1repressesR-30212.2875Pr-87
t(14;16)MZF1repressesR-30212.2875Pr-87
TRIOMZF1repressesR-30212.2875Pr-87
amp1qMZF1repressesR-30212.2875Pr-87
del13MZF1repressesR-30212.2875Pr-87
t(11;14)_cytogeneticMZF1repressesR-30212.2875Pr-87
t(14;16)_cytogeneticMZF1repressesR-30212.2875Pr-87
DNAH10MZF1activatesR-3022-2.32297Pr-139
FAT1MZF1activatesR-3022-2.32297Pr-139
FGFR3MZF1activatesR-3022-2.32297Pr-139
IRF4MZF1activatesR-3022-2.32297Pr-139
NRASMZF1activatesR-3022-2.32297Pr-139
PRKD2MZF1activatesR-3022-2.32297Pr-139
t(11;14)MZF1activatesR-3022-2.32297Pr-139
RNASeq_FGFR3_CallMZF1activatesR-3022-2.32297Pr-139
RNASeq_MAFA_CallMZF1activatesR-3022-2.32297Pr-139
t(14;16)MZF1activatesR-3022-2.32297Pr-139
t(4;14)MZF1activatesR-3022-2.32297Pr-139
del13MZF1activatesR-3022-2.32297Pr-139
t(11;14)_cytogeneticMZF1activatesR-3022-2.32297Pr-139
t(14;16)_cytogeneticMZF1activatesR-3022-2.32297Pr-139
t(4;14)_cytogeneticMZF1activatesR-3022-2.32297Pr-139
FAM46CMZF1repressesR-30202.57034Pr-8
FGFR3MZF1repressesR-30202.57034Pr-8
IRF4MZF1repressesR-30202.57034Pr-8
KIAA1244MZF1repressesR-30202.57034Pr-8
t(11;14)MZF1repressesR-30202.57034Pr-8
RNASeq_FGFR3_CallMZF1repressesR-30202.57034Pr-8
t(4;14)MZF1repressesR-30202.57034Pr-8
t(11;14)_cytogeneticMZF1repressesR-30202.57034Pr-8
t(4;14)_cytogeneticMZF1repressesR-30202.57034Pr-8
DIS3MZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DNAH10MZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAM46CMZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MAXMZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NRASMZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

PRKD2MZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_CallMZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_MAFA_CallMZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(14;16)MZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)MZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SETD2MZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)_cytogeneticMZF1activatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DCHS1MZF1activatesR-3019-3.42244Pr-35
DIS3MZF1activatesR-3019-3.42244Pr-35
FAM46CMZF1activatesR-3019-3.42244Pr-35
FAT3MZF1activatesR-3019-3.42244Pr-35
FGFR3MZF1activatesR-3019-3.42244Pr-35
IRF4MZF1activatesR-3019-3.42244Pr-35
MAXMZF1activatesR-3019-3.42244Pr-35
NRASMZF1activatesR-3019-3.42244Pr-35
PRKD2MZF1activatesR-3019-3.42244Pr-35
RELNMZF1activatesR-3019-3.42244Pr-35
t(11;14)MZF1activatesR-3019-3.42244Pr-35
RNASeq_FGFR3_CallMZF1activatesR-3019-3.42244Pr-35
RNASeq_MAFA_CallMZF1activatesR-3019-3.42244Pr-35
t(14;16)MZF1activatesR-3019-3.42244Pr-35
t(4;14)MZF1activatesR-3019-3.42244Pr-35
SETD2MZF1activatesR-3019-3.42244Pr-35
TRIOMZF1activatesR-3019-3.42244Pr-35
amp1qMZF1activatesR-3019-3.42244Pr-35
del13MZF1activatesR-3019-3.42244Pr-35
t(11;14)_cytogeneticMZF1activatesR-3019-3.42244Pr-35
t(14;16)_cytogeneticMZF1activatesR-3019-3.42244Pr-35
t(4;14)_cytogeneticMZF1activatesR-3019-3.42244Pr-35
DIS3MZF1activatesR-3023-3.63658Pr-103
DNAH10MZF1activatesR-3023-3.63658Pr-103
FAM46CMZF1activatesR-3023-3.63658Pr-103
FGFR3MZF1activatesR-3023-3.63658Pr-103
IRF4MZF1activatesR-3023-3.63658Pr-103
KIAA1244MZF1activatesR-3023-3.63658Pr-103
NRASMZF1activatesR-3023-3.63658Pr-103
PRKD2MZF1activatesR-3023-3.63658Pr-103
t(11;14)MZF1activatesR-3023-3.63658Pr-103
RNASeq_FGFR3_CallMZF1activatesR-3023-3.63658Pr-103
RNASeq_MAFA_CallMZF1activatesR-3023-3.63658Pr-103
t(14;16)MZF1activatesR-3023-3.63658Pr-103
t(4;14)MZF1activatesR-3023-3.63658Pr-103
t(11;14)_cytogeneticMZF1activatesR-3023-3.63658Pr-103
t(4;14)_cytogeneticMZF1activatesR-3023-3.63658Pr-103
DCHS1MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DIS3MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAM46CMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FGFR3MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

NRASMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RELNMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_CallMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_CallMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SETD2MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

TRIOMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

amp1qMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del13MZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)_cytogeneticMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)_cytogeneticMZF1repressesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.