Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

PRDM1 - PR/SET domain 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
639 ENSG00000057657 PRDM1 Q5T4E8

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: PRDM1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
BRAFPRDM1repressesR-20870.00684992Pr-117
DIS3PRDM1repressesR-20870.00684992Pr-117
FGFR3PRDM1repressesR-20870.00684992Pr-117
NEBPRDM1repressesR-20870.00684992Pr-117
RNASeq_FGFR3_CallPRDM1repressesR-20870.00684992Pr-117
t(14;16)PRDM1repressesR-20870.00684992Pr-117
t(4;14)PRDM1repressesR-20870.00684992Pr-117
del13PRDM1repressesR-20870.00684992Pr-117
del17PRDM1repressesR-20870.00684992Pr-117
t(4;14)_cytogeneticPRDM1repressesR-20870.00684992Pr-117
BRAFPRDM1activatesR-20760.102195Pr-0
NEBPRDM1activatesR-20760.102195Pr-0
del13PRDM1activatesR-20760.102195Pr-0
del17PRDM1activatesR-20760.102195Pr-0
t(14;16)PRDM1activatesR-2081-0.107496Pr-23
amp1qPRDM1activatesR-2081-0.107496Pr-23
del13PRDM1activatesR-2081-0.107496Pr-23
NEBPRDM1repressesR-20800.517642Pr-59
RNASeq_FGFR3_CallPRDM1repressesR-20800.517642Pr-59
t(4;14)PRDM1repressesR-20800.517642Pr-59
amp1qPRDM1repressesR-20800.517642Pr-59
del13PRDM1repressesR-20800.517642Pr-59
del1pPRDM1repressesR-20800.517642Pr-59
DIS3PRDM1activatesR-20750.612528Pr-14
t(14;16)PRDM1activatesR-20750.612528Pr-14
amp1qPRDM1activatesR-20750.612528Pr-14
del13PRDM1activatesR-20750.612528Pr-14
t(14;16)PRDM1activatesR-2088-0.627838Pr-15
amp1qPRDM1activatesR-2088-0.627838Pr-15
del13PRDM1activatesR-2088-0.627838Pr-15
NEBPRDM1activatesR-2073-1.18778Pr-0
amp1qPRDM1activatesR-2073-1.18778Pr-0
del13PRDM1activatesR-2073-1.18778Pr-0
NEBPRDM1activatesR-20741.22549Pr-1
t(14;16)PRDM1activatesR-20741.22549Pr-1
amp1qPRDM1activatesR-20741.22549Pr-1
del13PRDM1activatesR-20741.22549Pr-1
del1pPRDM1activatesR-20741.22549Pr-1
FGFR3PRDM1repressesR-2082-1.45635Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

DIS3PRDM1repressesR-2083-2.53559Pr-135
FGFR3PRDM1repressesR-2083-2.53559Pr-135
NEBPRDM1repressesR-2083-2.53559Pr-135
RNASeq_FGFR3_CallPRDM1repressesR-2083-2.53559Pr-135
t(14;16)PRDM1repressesR-2083-2.53559Pr-135
t(4;14)PRDM1repressesR-2083-2.53559Pr-135
amp1qPRDM1repressesR-2083-2.53559Pr-135
del13PRDM1repressesR-2083-2.53559Pr-135
t(4;14)_cytogeneticPRDM1repressesR-2083-2.53559Pr-135
RNASeq_FGFR3_CallPRDM1activatesR-2079-2.55743Pr-11
t(4;14)PRDM1activatesR-2079-2.55743Pr-11
amp1qPRDM1activatesR-2079-2.55743Pr-11
del13PRDM1activatesR-2079-2.55743Pr-11
t(4;14)_cytogeneticPRDM1activatesR-2079-2.55743Pr-11
DIS3PRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

FGFR3PRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_CallPRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)PRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)PRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qPRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13PRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del1pPRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticPRDM1activatesR-20854.22077Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DIS3PRDM1activatesR-20784.83987Pr-48
FGFR3PRDM1activatesR-20784.83987Pr-48
RNASeq_FGFR3_CallPRDM1activatesR-20784.83987Pr-48
t(14;16)PRDM1activatesR-20784.83987Pr-48
t(4;14)PRDM1activatesR-20784.83987Pr-48
amp1qPRDM1activatesR-20784.83987Pr-48
del13PRDM1activatesR-20784.83987Pr-48
t(4;14)_cytogeneticPRDM1activatesR-20784.83987Pr-48

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.