Program

Causal Mechanistic Flows with regulons in program Pr-93

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ATMdown-regulatesPLAG1repressesR-15220.14075911Pr-93
DIS3down-regulatesPLAG1repressesR-15220.14075911Pr-93
FAM46Cup-regulatesPLAG1repressesR-15220.14075911Pr-93
IRF4down-regulatesPLAG1repressesR-15220.14075911Pr-93
KLHL6up-regulatesPLAG1repressesR-15220.14075911Pr-93
t(11;14)down-regulatesPLAG1repressesR-15220.14075911Pr-93
RNASeq_MAFA_Calldown-regulatesPLAG1repressesR-15220.14075911Pr-93
RNASeq_MAFB_Calldown-regulatesPLAG1repressesR-15220.14075911Pr-93
t(14;16)down-regulatesPLAG1repressesR-15220.14075911Pr-93
t(11;14)_cytogeneticdown-regulatesPLAG1repressesR-15220.14075911Pr-93
t(14;16)_cytogeneticdown-regulatesPLAG1repressesR-15220.14075911Pr-93
DNAH5up-regulatesATF1activatesR-5640.29775910Pr-93
MAXup-regulatesATF1activatesR-5640.29775910Pr-93
t(11;14)up-regulatesATF1activatesR-5640.29775910Pr-93
RNASeq_MAFA_Callup-regulatesATF1activatesR-5640.29775910Pr-93
RNASeq_MAFB_Callup-regulatesATF1activatesR-5640.29775910Pr-93
t(14;16)_cytogeneticup-regulatesATF1activatesR-5640.29775910Pr-93
ACTG1down-regulatesETS1activatesR-131.079996Pr-93
ATMup-regulatesETS1activatesR-131.079996Pr-93
DMDup-regulatesETS1activatesR-131.079996Pr-93
NRASdown-regulatesETS1activatesR-131.079996Pr-93
RNASeq_CCND2_Calldown-regulatesETS1activatesR-131.079996Pr-93
RNASeq_MAFA_Callup-regulatesETS1activatesR-131.079996Pr-93
RNASeq_MAFB_Callup-regulatesETS1activatesR-131.079996Pr-93
t(14;16)up-regulatesETS1activatesR-131.079996Pr-93
TRAF3up-regulatesETS1activatesR-131.079996Pr-93
t(11;14)up-regulatesFOXJ2activatesR-14381.1431621Pr-93
t(14;16)up-regulatesFOXJ2activatesR-14381.1431621Pr-93
t(4;14)up-regulatesFOXJ2activatesR-14381.1431621Pr-93
amp1qup-regulatesFOXJ2activatesR-14381.1431621Pr-93
del13up-regulatesFOXJ2activatesR-14381.1431621Pr-93
BAI3down-regulatesSTAT3activatesR-3101.160967Pr-93
NRASdown-regulatesSTAT3activatesR-3101.160967Pr-93
RNASeq_FGFR3_Callup-regulatesSTAT3activatesR-3101.160967Pr-93
t(14;16)up-regulatesSTAT3activatesR-3101.160967Pr-93
t(4;14)up-regulatesSTAT3activatesR-3101.160967Pr-93
amp1qup-regulatesSTAT3activatesR-3101.160967Pr-93
del13up-regulatesSTAT3activatesR-3101.160967Pr-93
t(11;14)_cytogeneticdown-regulatesSTAT3activatesR-3101.160967Pr-93
DMDup-regulatesFOXP1activatesR-31311.2174621Pr-93
PRDM1up-regulatesFOXP1activatesR-31311.2174621Pr-93
t(11;14)up-regulatesFOXP1activatesR-31311.2174621Pr-93
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-31311.2174621Pr-93
t(14;16)up-regulatesFOXP1activatesR-31311.2174621Pr-93
amp1qup-regulatesFOXP1activatesR-31311.2174621Pr-93
del13up-regulatesFOXP1activatesR-31311.2174621Pr-93
del1pup-regulatesFOXP1activatesR-31311.2174621Pr-93
t(11;14)_cytogeneticup-regulatesFOXP1activatesR-31311.2174621Pr-93
ATMdown-regulatesHMGA1repressesR-8261.2426617Pr-93
DIS3down-regulatesHMGA1repressesR-8261.2426617Pr-93
FAM46Cup-regulatesHMGA1repressesR-8261.2426617Pr-93
FGFR3down-regulatesHMGA1repressesR-8261.2426617Pr-93
IRF4down-regulatesHMGA1repressesR-8261.2426617Pr-93
NRASup-regulatesHMGA1repressesR-8261.2426617Pr-93
t(11;14)down-regulatesHMGA1repressesR-8261.2426617Pr-93
RNASeq_FGFR3_Calldown-regulatesHMGA1repressesR-8261.2426617Pr-93
RNASeq_MAFA_Calldown-regulatesHMGA1repressesR-8261.2426617Pr-93
RNASeq_MAFB_Calldown-regulatesHMGA1repressesR-8261.2426617Pr-93
t(14;16)down-regulatesHMGA1repressesR-8261.2426617Pr-93
t(4;14)down-regulatesHMGA1repressesR-8261.2426617Pr-93
TRIOdown-regulatesHMGA1repressesR-8261.2426617Pr-93
del13down-regulatesHMGA1repressesR-8261.2426617Pr-93
t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-8261.2426617Pr-93
t(4;14)_cytogeneticdown-regulatesHMGA1repressesR-8261.2426617Pr-93
DCHS1up-regulatesSP1activatesR-27251.3790619Pr-93
DIS3up-regulatesSP1activatesR-27251.3790619Pr-93
FAM46Cdown-regulatesSP1activatesR-27251.3790619Pr-93
PTPRDup-regulatesSP1activatesR-27251.3790619Pr-93
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27251.3790619Pr-93
RNASeq_MAFA_Callup-regulatesSP1activatesR-27251.3790619Pr-93
RNASeq_MAFB_Callup-regulatesSP1activatesR-27251.3790619Pr-93
t(14;16)up-regulatesSP1activatesR-27251.3790619Pr-93
t(4;14)up-regulatesSP1activatesR-27251.3790619Pr-93
TTNup-regulatesSP1activatesR-27251.3790619Pr-93
amp1qup-regulatesSP1activatesR-27251.3790619Pr-93
t(14;16)_cytogeneticup-regulatesSP1activatesR-27251.3790619Pr-93
t(4;14)_cytogeneticup-regulatesSP1activatesR-27251.3790619Pr-93
CSMD1up-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
NRASdown-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
PCLOup-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
RNASeq_MAFA_Callup-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
RNASeq_MAFB_Callup-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
t(14;16)up-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
SP140up-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
SYNE2up-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
del13up-regulatesENSG00000087510activatesR-2630-2.365666Pr-93
t(14;16)_cytogeneticup-regulatesENSG00000087510activatesR-2630-2.365666Pr-93

Regulons in program Pr-93

Regulon Cox Hazard Ratio # genes # causal flows
R-15220.1407591111
R-5640.297759106
R-131.0799969
R-14381.14316215
R-3101.1609678
R-31311.21746219
R-8261.242661716
R-27251.379061913
R-2630-2.36566610

Genes in program Pr-93

EnsEMBL IdEntrez IdPreferred
ENSG00000176597 84002B3GNT5
ENSG00000178209 5339PLEC
ENSG00000189221
ENSG00000196549 4311MME
ENSG00000196757 90592ZNF700
ENSG00000197157 27044SND1
ENSG00000197415 79674VEPH1
ENSG00000198464 147657ZNF480
ENSG00000259305 100533106ZHX1-C8orf76

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions