Program

Causal Mechanistic Flows with regulons in program Pr-87

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3down-regulatesHOXA3repressesR-222-0.1470114Pr-87
FAM46Cup-regulatesHOXA3repressesR-222-0.1470114Pr-87
t(11;14)down-regulatesHOXA3repressesR-222-0.1470114Pr-87
RNASeq_FGFR3_Calldown-regulatesHOXA3repressesR-222-0.1470114Pr-87
RNASeq_MAFB_Calldown-regulatesHOXA3repressesR-222-0.1470114Pr-87
t(14;16)down-regulatesHOXA3repressesR-222-0.1470114Pr-87
t(4;14)down-regulatesHOXA3repressesR-222-0.1470114Pr-87
t(4;14)_cytogeneticdown-regulatesHOXA3repressesR-222-0.1470114Pr-87
AHNAK2up-regulatesSREBF1activatesR-11370.96374911Pr-87
ATMup-regulatesSREBF1activatesR-11370.96374911Pr-87
DIS3up-regulatesSREBF1activatesR-11370.96374911Pr-87
DNAH9up-regulatesSREBF1activatesR-11370.96374911Pr-87
FLGup-regulatesSREBF1activatesR-11370.96374911Pr-87
MACF1up-regulatesSREBF1activatesR-11370.96374911Pr-87
NRASdown-regulatesSREBF1activatesR-11370.96374911Pr-87
PTPRDup-regulatesSREBF1activatesR-11370.96374911Pr-87
RNASeq_FGFR3_Callup-regulatesSREBF1activatesR-11370.96374911Pr-87
RNASeq_MAFA_Callup-regulatesSREBF1activatesR-11370.96374911Pr-87
RNASeq_MAFB_Callup-regulatesSREBF1activatesR-11370.96374911Pr-87
t(14;16)up-regulatesSREBF1activatesR-11370.96374911Pr-87
t(4;14)up-regulatesSREBF1activatesR-11370.96374911Pr-87
ROBO2up-regulatesSREBF1activatesR-11370.96374911Pr-87
SYNE2up-regulatesSREBF1activatesR-11370.96374911Pr-87
TRIOup-regulatesSREBF1activatesR-11370.96374911Pr-87
amp1qup-regulatesSREBF1activatesR-11370.96374911Pr-87
del13up-regulatesSREBF1activatesR-11370.96374911Pr-87
t(14;16)_cytogeneticup-regulatesSREBF1activatesR-11370.96374911Pr-87
t(4;14)_cytogeneticup-regulatesSREBF1activatesR-11370.96374911Pr-87
del13up-regulatesRARAactivatesR-1500.9959720Pr-87
AHNAK2down-regulatesVDRrepressesR-12281.037114Pr-87
DIS3down-regulatesVDRrepressesR-12281.037114Pr-87
FAM46Cup-regulatesVDRrepressesR-12281.037114Pr-87
MACF1down-regulatesVDRrepressesR-12281.037114Pr-87
RNASeq_FGFR3_Calldown-regulatesVDRrepressesR-12281.037114Pr-87
t(14;16)down-regulatesVDRrepressesR-12281.037114Pr-87
t(4;14)down-regulatesVDRrepressesR-12281.037114Pr-87
TRIOdown-regulatesVDRrepressesR-12281.037114Pr-87
amp1qdown-regulatesVDRrepressesR-12281.037114Pr-87
del13down-regulatesVDRrepressesR-12281.037114Pr-87
t(4;14)_cytogeneticdown-regulatesVDRrepressesR-12281.037114Pr-87
PRDM1up-regulatesELF4activatesR-23311.0693331Pr-87
RNASeq_FGFR3_Callup-regulatesELF4activatesR-23311.0693331Pr-87
t(14;16)up-regulatesELF4activatesR-23311.0693331Pr-87
del1pup-regulatesELF4activatesR-23311.0693331Pr-87
AHNAK2up-regulatesSP1activatesR-27131.0811835Pr-87
DCHS1up-regulatesSP1activatesR-27131.0811835Pr-87
DIS3up-regulatesSP1activatesR-27131.0811835Pr-87
DNAH9up-regulatesSP1activatesR-27131.0811835Pr-87
FAM46Cdown-regulatesSP1activatesR-27131.0811835Pr-87
PTPRDup-regulatesSP1activatesR-27131.0811835Pr-87
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27131.0811835Pr-87
RNASeq_MAFA_Callup-regulatesSP1activatesR-27131.0811835Pr-87
RNASeq_MAFB_Callup-regulatesSP1activatesR-27131.0811835Pr-87
t(14;16)up-regulatesSP1activatesR-27131.0811835Pr-87
t(4;14)up-regulatesSP1activatesR-27131.0811835Pr-87
ROBO2up-regulatesSP1activatesR-27131.0811835Pr-87
TRAF3up-regulatesSP1activatesR-27131.0811835Pr-87
TRIOup-regulatesSP1activatesR-27131.0811835Pr-87
TTNup-regulatesSP1activatesR-27131.0811835Pr-87
amp1qup-regulatesSP1activatesR-27131.0811835Pr-87
t(14;16)_cytogeneticup-regulatesSP1activatesR-27131.0811835Pr-87
t(4;14)_cytogeneticup-regulatesSP1activatesR-27131.0811835Pr-87
DMDup-regulatesFOXP1activatesR-31251.1135729Pr-87
PRDM1up-regulatesFOXP1activatesR-31251.1135729Pr-87
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-31251.1135729Pr-87
t(14;16)up-regulatesFOXP1activatesR-31251.1135729Pr-87
amp1qup-regulatesFOXP1activatesR-31251.1135729Pr-87
del13up-regulatesFOXP1activatesR-31251.1135729Pr-87
del1pup-regulatesFOXP1activatesR-31251.1135729Pr-87
CSMD1down-regulatesTCF3repressesR-20521.1743735Pr-87
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-20521.1743735Pr-87
t(14;16)down-regulatesTCF3repressesR-20521.1743735Pr-87
ATMup-regulatesSPIBactivatesR-6641.3246822Pr-87
DIS3up-regulatesSPIBactivatesR-6641.3246822Pr-87
FAM46Cdown-regulatesSPIBactivatesR-6641.3246822Pr-87
MACF1up-regulatesSPIBactivatesR-6641.3246822Pr-87
NRASdown-regulatesSPIBactivatesR-6641.3246822Pr-87
RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6641.3246822Pr-87
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6641.3246822Pr-87
RNASeq_MAFB_Callup-regulatesSPIBactivatesR-6641.3246822Pr-87
t(14;16)up-regulatesSPIBactivatesR-6641.3246822Pr-87
t(4;14)up-regulatesSPIBactivatesR-6641.3246822Pr-87
TRIOup-regulatesSPIBactivatesR-6641.3246822Pr-87
amp1qup-regulatesSPIBactivatesR-6641.3246822Pr-87
del13up-regulatesSPIBactivatesR-6641.3246822Pr-87
del1pup-regulatesSPIBactivatesR-6641.3246822Pr-87
t(4;14)_cytogeneticup-regulatesSPIBactivatesR-6641.3246822Pr-87
DIS3down-regulatesEGR1repressesR-28971.4427421Pr-87
t(11;14)down-regulatesEGR1repressesR-28971.4427421Pr-87
RNASeq_FGFR3_Calldown-regulatesEGR1repressesR-28971.4427421Pr-87
t(4;14)down-regulatesEGR1repressesR-28971.4427421Pr-87
t(4;14)_cytogeneticdown-regulatesEGR1repressesR-28971.4427421Pr-87
DIS3down-regulatesPAX6repressesR-15441.5472621Pr-87
FAM46Cup-regulatesPAX6repressesR-15441.5472621Pr-87
IRF4down-regulatesPAX6repressesR-15441.5472621Pr-87
t(11;14)down-regulatesPAX6repressesR-15441.5472621Pr-87
t(14;16)down-regulatesPAX6repressesR-15441.5472621Pr-87
t(4;14)down-regulatesPAX6repressesR-15441.5472621Pr-87
amp1qdown-regulatesPAX6repressesR-15441.5472621Pr-87
del13down-regulatesPAX6repressesR-15441.5472621Pr-87
t(11;14)_cytogeneticdown-regulatesPAX6repressesR-15441.5472621Pr-87
IRF4up-regulatesPAX5activatesR-23761.561559Pr-87
t(11;14)up-regulatesPAX5activatesR-23761.561559Pr-87
t(11;14)_cytogeneticup-regulatesPAX5activatesR-23761.561559Pr-87
ATMup-regulatesMAFactivatesR-1011.5697821Pr-87
DIS3up-regulatesMAFactivatesR-1011.5697821Pr-87
FAM46Cdown-regulatesMAFactivatesR-1011.5697821Pr-87
NRASdown-regulatesMAFactivatesR-1011.5697821Pr-87
RNASeq_FGFR3_Callup-regulatesMAFactivatesR-1011.5697821Pr-87
RNASeq_MAFA_Callup-regulatesMAFactivatesR-1011.5697821Pr-87
RNASeq_MAFB_Callup-regulatesMAFactivatesR-1011.5697821Pr-87
t(14;16)up-regulatesMAFactivatesR-1011.5697821Pr-87
t(4;14)up-regulatesMAFactivatesR-1011.5697821Pr-87
amp1qup-regulatesMAFactivatesR-1011.5697821Pr-87
del13up-regulatesMAFactivatesR-1011.5697821Pr-87
t(14;16)_cytogeneticup-regulatesMAFactivatesR-1011.5697821Pr-87
t(4;14)_cytogeneticup-regulatesMAFactivatesR-1011.5697821Pr-87
ATMup-regulatesMYBactivatesR-6171.615214Pr-87
CSMD1up-regulatesMYBactivatesR-6171.615214Pr-87
DIS3up-regulatesMYBactivatesR-6171.615214Pr-87
DMDup-regulatesMYBactivatesR-6171.615214Pr-87
FAM46Cdown-regulatesMYBactivatesR-6171.615214Pr-87
IRF4up-regulatesMYBactivatesR-6171.615214Pr-87
KRASdown-regulatesMYBactivatesR-6171.615214Pr-87
MACF1up-regulatesMYBactivatesR-6171.615214Pr-87
NRASdown-regulatesMYBactivatesR-6171.615214Pr-87
t(11;14)up-regulatesMYBactivatesR-6171.615214Pr-87
RNASeq_MAFA_Callup-regulatesMYBactivatesR-6171.615214Pr-87
RNASeq_MAFB_Callup-regulatesMYBactivatesR-6171.615214Pr-87
t(14;16)up-regulatesMYBactivatesR-6171.615214Pr-87
TRIOup-regulatesMYBactivatesR-6171.615214Pr-87
amp1qup-regulatesMYBactivatesR-6171.615214Pr-87
del13up-regulatesMYBactivatesR-6171.615214Pr-87
del1pup-regulatesMYBactivatesR-6171.615214Pr-87
t(11;14)_cytogeneticup-regulatesMYBactivatesR-6171.615214Pr-87
t(14;16)_cytogeneticup-regulatesMYBactivatesR-6171.615214Pr-87
NRASdown-regulatesSTAT3activatesR-3041.7574215Pr-87
t(14;16)up-regulatesSTAT3activatesR-3041.7574215Pr-87
amp1qup-regulatesSTAT3activatesR-3041.7574215Pr-87
del13up-regulatesSTAT3activatesR-3041.7574215Pr-87
ATMdown-regulatesHMGA1repressesR-8201.7951724Pr-87
DIS3down-regulatesHMGA1repressesR-8201.7951724Pr-87
FAM46Cup-regulatesHMGA1repressesR-8201.7951724Pr-87
IRF4down-regulatesHMGA1repressesR-8201.7951724Pr-87
NRASup-regulatesHMGA1repressesR-8201.7951724Pr-87
t(11;14)down-regulatesHMGA1repressesR-8201.7951724Pr-87
RNASeq_FGFR3_Calldown-regulatesHMGA1repressesR-8201.7951724Pr-87
RNASeq_MAFA_Calldown-regulatesHMGA1repressesR-8201.7951724Pr-87
RNASeq_MAFB_Calldown-regulatesHMGA1repressesR-8201.7951724Pr-87
t(14;16)down-regulatesHMGA1repressesR-8201.7951724Pr-87
t(4;14)down-regulatesHMGA1repressesR-8201.7951724Pr-87
TRIOdown-regulatesHMGA1repressesR-8201.7951724Pr-87
del13down-regulatesHMGA1repressesR-8201.7951724Pr-87
t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-8201.7951724Pr-87
t(4;14)_cytogeneticdown-regulatesHMGA1repressesR-8201.7951724Pr-87
AHNAK2up-regulatesMAZactivatesR-4951.848724Pr-87
DCHS1up-regulatesMAZactivatesR-4951.848724Pr-87
DIS3up-regulatesMAZactivatesR-4951.848724Pr-87
DNAH10up-regulatesMAZactivatesR-4951.848724Pr-87
DNAH8up-regulatesMAZactivatesR-4951.848724Pr-87
FAM46Cdown-regulatesMAZactivatesR-4951.848724Pr-87
MACF1up-regulatesMAZactivatesR-4951.848724Pr-87
NRASdown-regulatesMAZactivatesR-4951.848724Pr-87
PRKD2up-regulatesMAZactivatesR-4951.848724Pr-87
RNASeq_FGFR3_Callup-regulatesMAZactivatesR-4951.848724Pr-87
RNASeq_MAFA_Callup-regulatesMAZactivatesR-4951.848724Pr-87
RNASeq_MAFB_Callup-regulatesMAZactivatesR-4951.848724Pr-87
t(14;16)up-regulatesMAZactivatesR-4951.848724Pr-87
t(4;14)up-regulatesMAZactivatesR-4951.848724Pr-87
TP53up-regulatesMAZactivatesR-4951.848724Pr-87
TRAF3up-regulatesMAZactivatesR-4951.848724Pr-87
TRIOup-regulatesMAZactivatesR-4951.848724Pr-87
amp1qup-regulatesMAZactivatesR-4951.848724Pr-87
del13up-regulatesMAZactivatesR-4951.848724Pr-87
t(14;16)_cytogeneticup-regulatesMAZactivatesR-4951.848724Pr-87
t(4;14)_cytogeneticup-regulatesMAZactivatesR-4951.848724Pr-87
BRAFdown-regulatesMZF1repressesR-30212.287510Pr-87
DCHS1down-regulatesMZF1repressesR-30212.287510Pr-87
DIS3down-regulatesMZF1repressesR-30212.287510Pr-87
FAM46Cup-regulatesMZF1repressesR-30212.287510Pr-87
IRF4down-regulatesMZF1repressesR-30212.287510Pr-87
NRASup-regulatesMZF1repressesR-30212.287510Pr-87
t(11;14)down-regulatesMZF1repressesR-30212.287510Pr-87
RNASeq_MAFA_Calldown-regulatesMZF1repressesR-30212.287510Pr-87
t(14;16)down-regulatesMZF1repressesR-30212.287510Pr-87
TRIOdown-regulatesMZF1repressesR-30212.287510Pr-87
amp1qdown-regulatesMZF1repressesR-30212.287510Pr-87
del13down-regulatesMZF1repressesR-30212.287510Pr-87
t(11;14)_cytogeneticdown-regulatesMZF1repressesR-30212.287510Pr-87
t(14;16)_cytogeneticdown-regulatesMZF1repressesR-30212.287510Pr-87
ATMup-regulatesPEBP1activatesR-17543.032687Pr-87
CACNA1Hup-regulatesPEBP1activatesR-17543.032687Pr-87
CSMD1up-regulatesPEBP1activatesR-17543.032687Pr-87
DIS3up-regulatesPEBP1activatesR-17543.032687Pr-87
FAM46Cdown-regulatesPEBP1activatesR-17543.032687Pr-87
NRASdown-regulatesPEBP1activatesR-17543.032687Pr-87
RNASeq_MAFA_Callup-regulatesPEBP1activatesR-17543.032687Pr-87
RNASeq_MAFB_Callup-regulatesPEBP1activatesR-17543.032687Pr-87
t(14;16)up-regulatesPEBP1activatesR-17543.032687Pr-87
ROBO2up-regulatesPEBP1activatesR-17543.032687Pr-87
TRIOup-regulatesPEBP1activatesR-17543.032687Pr-87
amp1qup-regulatesPEBP1activatesR-17543.032687Pr-87
del13up-regulatesPEBP1activatesR-17543.032687Pr-87
del1pup-regulatesPEBP1activatesR-17543.032687Pr-87
t(14;16)_cytogeneticup-regulatesPEBP1activatesR-17543.032687Pr-87
ATMup-regulatesSPIBactivatesR-6783.321596Pr-87
DCHS1up-regulatesSPIBactivatesR-6783.321596Pr-87
DIS3up-regulatesSPIBactivatesR-6783.321596Pr-87
DNAH10up-regulatesSPIBactivatesR-6783.321596Pr-87
FAM46Cdown-regulatesSPIBactivatesR-6783.321596Pr-87
MACF1up-regulatesSPIBactivatesR-6783.321596Pr-87
MPDZdown-regulatesSPIBactivatesR-6783.321596Pr-87
NRASdown-regulatesSPIBactivatesR-6783.321596Pr-87
OBSCNup-regulatesSPIBactivatesR-6783.321596Pr-87
PRDM1up-regulatesSPIBactivatesR-6783.321596Pr-87
RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6783.321596Pr-87
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6783.321596Pr-87
RNASeq_MAFB_Callup-regulatesSPIBactivatesR-6783.321596Pr-87
t(14;16)up-regulatesSPIBactivatesR-6783.321596Pr-87
t(4;14)up-regulatesSPIBactivatesR-6783.321596Pr-87
TRIOup-regulatesSPIBactivatesR-6783.321596Pr-87
UBR4up-regulatesSPIBactivatesR-6783.321596Pr-87
amp1qup-regulatesSPIBactivatesR-6783.321596Pr-87
del13up-regulatesSPIBactivatesR-6783.321596Pr-87
del1pup-regulatesSPIBactivatesR-6783.321596Pr-87
t(4;14)_cytogeneticup-regulatesSPIBactivatesR-6783.321596Pr-87

Regulons in program Pr-87

Regulon Cox Hazard Ratio # genes # causal flows
R-222-0.14701148
R-11370.9637491120
R-1500.99597201
R-12281.03711411
R-23311.06933314
R-27131.081183518
R-31251.11357297
R-20521.17437353
R-6641.324682215
R-28971.44274215
R-15441.54726219
R-23761.5615593
R-1011.569782113
R-6171.61521419
R-3041.75742154
R-8201.795172415
R-4951.84872421
R-30212.28751014
R-17543.03268715
R-6783.32159621

Genes in program Pr-87

EnsEMBL IdEntrez IdPreferred
ENSG00000176809 374819LRRC37A3
ENSG00000187583 84069PLEKHN1
ENSG00000188157 375790AGRN
ENSG00000188732 340277FAM221A
ENSG00000189120
ENSG00000189266 55629PNRC2
ENSG00000196365 9361LONP1
ENSG00000196917 27198HCAR1
ENSG00000198088 54830NUP62CL
ENSG00000198816 140467ZNF358
ENSG00000204130 55680RUFY2
ENSG00000204165 158830CXorf65
ENSG00000204370 6392SDHD
ENSG00000204856 29902FAM216A
ENSG00000213694
ENSG00000214226 339210C17orf67
ENSG00000215251 60493FASTKD5
ENSG00000255302 23741EID1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions