Program

Causal Mechanistic Flows with regulons in program Pr-85

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DMDup-regulatesSMAD3activatesR-2966-0.06606246Pr-85
KRASdown-regulatesSMAD3activatesR-2966-0.06606246Pr-85
NRASdown-regulatesSMAD3activatesR-2966-0.06606246Pr-85
RNASeq_MAFA_Callup-regulatesSMAD3activatesR-2966-0.06606246Pr-85
t(14;16)up-regulatesSMAD3activatesR-2966-0.06606246Pr-85
ROBO2up-regulatesSMAD3activatesR-2966-0.06606246Pr-85
amp1qup-regulatesSMAD3activatesR-2966-0.06606246Pr-85
del13up-regulatesSMAD3activatesR-2966-0.06606246Pr-85
RNASeq_MAFB_Callup-regulatesENSG00000186564activatesR-4840.1092777Pr-85
t(14;16)up-regulatesENSG00000186564activatesR-4840.1092777Pr-85
AHNAK2down-regulatesHSF2repressesR-3159-0.21358615Pr-85
KRASup-regulatesHSF2repressesR-3159-0.21358615Pr-85
MYO10down-regulatesHSF2repressesR-3159-0.21358615Pr-85
t(11;14)up-regulatesHSF2repressesR-3159-0.21358615Pr-85
RNASeq_MAFA_Calldown-regulatesHSF2repressesR-3159-0.21358615Pr-85
RNASeq_MAFB_Calldown-regulatesHSF2repressesR-3159-0.21358615Pr-85
t(11;14)_cytogeneticup-regulatesHSF2repressesR-3159-0.21358615Pr-85
t(14;16)_cytogeneticdown-regulatesHSF2repressesR-3159-0.21358615Pr-85
RNASeq_MAFA_Callup-regulatesARID5AactivatesR-597-0.29834618Pr-85
t(14;16)up-regulatesARID5AactivatesR-597-0.29834618Pr-85
amp1qup-regulatesARID5AactivatesR-597-0.29834618Pr-85
del13up-regulatesARID5AactivatesR-597-0.29834618Pr-85
del1pup-regulatesARID5AactivatesR-597-0.29834618Pr-85
ATMup-regulatesSPIBactivatesR-6610.3936445Pr-85
DCHS1up-regulatesSPIBactivatesR-6610.3936445Pr-85
DIS3up-regulatesSPIBactivatesR-6610.3936445Pr-85
FAM46Cdown-regulatesSPIBactivatesR-6610.3936445Pr-85
MACF1up-regulatesSPIBactivatesR-6610.3936445Pr-85
NRASdown-regulatesSPIBactivatesR-6610.3936445Pr-85
OBSCNup-regulatesSPIBactivatesR-6610.3936445Pr-85
PRDM1up-regulatesSPIBactivatesR-6610.3936445Pr-85
RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6610.3936445Pr-85
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6610.3936445Pr-85
RNASeq_MAFB_Callup-regulatesSPIBactivatesR-6610.3936445Pr-85
t(14;16)up-regulatesSPIBactivatesR-6610.3936445Pr-85
t(4;14)up-regulatesSPIBactivatesR-6610.3936445Pr-85
TRIOup-regulatesSPIBactivatesR-6610.3936445Pr-85
amp1qup-regulatesSPIBactivatesR-6610.3936445Pr-85
del13up-regulatesSPIBactivatesR-6610.3936445Pr-85
del1pup-regulatesSPIBactivatesR-6610.3936445Pr-85
t(4;14)_cytogeneticup-regulatesSPIBactivatesR-6610.3936445Pr-85
ATMup-regulatesNFATC2activatesR-16880.55167727Pr-85
CACNA1Hup-regulatesNFATC2activatesR-16880.55167727Pr-85
CSMD1up-regulatesNFATC2activatesR-16880.55167727Pr-85
NRASdown-regulatesNFATC2activatesR-16880.55167727Pr-85
PRDM1up-regulatesNFATC2activatesR-16880.55167727Pr-85
RNASeq_MAFA_Callup-regulatesNFATC2activatesR-16880.55167727Pr-85
RNASeq_MAFB_Callup-regulatesNFATC2activatesR-16880.55167727Pr-85
t(14;16)up-regulatesNFATC2activatesR-16880.55167727Pr-85
amp1qup-regulatesNFATC2activatesR-16880.55167727Pr-85
del13up-regulatesNFATC2activatesR-16880.55167727Pr-85
del1pup-regulatesNFATC2activatesR-16880.55167727Pr-85
t(14;16)_cytogeneticup-regulatesNFATC2activatesR-16880.55167727Pr-85
AHNAK2up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
CMYA5up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
MUC12up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
NEBup-regulatesZBTB3activatesR-1272-0.5686617Pr-85
t(11;14)down-regulatesZBTB3activatesR-1272-0.5686617Pr-85
SDK1up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
SYNE1up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
TACC2up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
XIRP2up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
del17up-regulatesZBTB3activatesR-1272-0.5686617Pr-85
t(11;14)_cytogeneticdown-regulatesZBTB3activatesR-1272-0.5686617Pr-85
t(14;16)_cytogeneticup-regulatesZBTB3activatesR-1272-0.5686617Pr-85
PRDM1up-regulatesELF4activatesR-23280.60917645Pr-85
RNASeq_FGFR3_Callup-regulatesELF4activatesR-23280.60917645Pr-85
t(14;16)up-regulatesELF4activatesR-23280.60917645Pr-85
del1pup-regulatesELF4activatesR-23280.60917645Pr-85
AHNAK2up-regulatesMYBactivatesR-6150.66814919Pr-85
ATMup-regulatesMYBactivatesR-6150.66814919Pr-85
CSMD1up-regulatesMYBactivatesR-6150.66814919Pr-85
DMDup-regulatesMYBactivatesR-6150.66814919Pr-85
FAM46Cdown-regulatesMYBactivatesR-6150.66814919Pr-85
KRASdown-regulatesMYBactivatesR-6150.66814919Pr-85
NRASdown-regulatesMYBactivatesR-6150.66814919Pr-85
PTPRDup-regulatesMYBactivatesR-6150.66814919Pr-85
RNASeq_MAFA_Callup-regulatesMYBactivatesR-6150.66814919Pr-85
RNASeq_MAFB_Callup-regulatesMYBactivatesR-6150.66814919Pr-85
t(14;16)up-regulatesMYBactivatesR-6150.66814919Pr-85
t(4;14)up-regulatesMYBactivatesR-6150.66814919Pr-85
ROBO2up-regulatesMYBactivatesR-6150.66814919Pr-85
SYNE2up-regulatesMYBactivatesR-6150.66814919Pr-85
TRIOup-regulatesMYBactivatesR-6150.66814919Pr-85
amp1qup-regulatesMYBactivatesR-6150.66814919Pr-85
del13up-regulatesMYBactivatesR-6150.66814919Pr-85
del1pup-regulatesMYBactivatesR-6150.66814919Pr-85
t(14;16)_cytogeneticup-regulatesMYBactivatesR-6150.66814919Pr-85
AHNAK2up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
DSCAML1up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
MACF1up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
MUC12up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
NRASdown-regulatesSTAT5BactivatesR-23660.81911114Pr-85
PRDM1up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
RNASeq_FGFR3_Callup-regulatesSTAT5BactivatesR-23660.81911114Pr-85
RNASeq_MAFA_Callup-regulatesSTAT5BactivatesR-23660.81911114Pr-85
RNASeq_MAFB_Callup-regulatesSTAT5BactivatesR-23660.81911114Pr-85
t(14;16)up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
t(4;14)up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
del13up-regulatesSTAT5BactivatesR-23660.81911114Pr-85
t(14;16)_cytogeneticup-regulatesSTAT5BactivatesR-23660.81911114Pr-85
t(4;14)_cytogeneticup-regulatesSTAT5BactivatesR-23660.81911114Pr-85
FLGdown-regulatesPAX5repressesR-23740.98364717Pr-85
KRASup-regulatesPAX5repressesR-23740.98364717Pr-85
MUC12down-regulatesPAX5repressesR-23740.98364717Pr-85
NRASup-regulatesPAX5repressesR-23740.98364717Pr-85
RELNdown-regulatesPAX5repressesR-23740.98364717Pr-85
t(11;14)up-regulatesPAX5repressesR-23740.98364717Pr-85
RNASeq_FGFR3_Calldown-regulatesPAX5repressesR-23740.98364717Pr-85
RNASeq_MAFA_Calldown-regulatesPAX5repressesR-23740.98364717Pr-85
t(14;16)down-regulatesPAX5repressesR-23740.98364717Pr-85
t(4;14)down-regulatesPAX5repressesR-23740.98364717Pr-85
amp1qdown-regulatesPAX5repressesR-23740.98364717Pr-85
del13down-regulatesPAX5repressesR-23740.98364717Pr-85
t(11;14)_cytogeneticup-regulatesPAX5repressesR-23740.98364717Pr-85
t(14;16)_cytogeneticdown-regulatesPAX5repressesR-23740.98364717Pr-85
t(4;14)_cytogeneticdown-regulatesPAX5repressesR-23740.98364717Pr-85
RNASeq_CCND2_Calldown-regulatesSTAT4activatesR-26471.0367628Pr-85
RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-26471.0367628Pr-85
RNASeq_MAFA_Callup-regulatesSTAT4activatesR-26471.0367628Pr-85
t(14;16)up-regulatesSTAT4activatesR-26471.0367628Pr-85
t(4;14)up-regulatesSTAT4activatesR-26471.0367628Pr-85
SP140up-regulatesSTAT4activatesR-26471.0367628Pr-85
t(4;14)_cytogeneticup-regulatesSTAT4activatesR-26471.0367628Pr-85
DIS3down-regulatesTP53repressesR-3601.3344225Pr-85
FAM46Cup-regulatesTP53repressesR-3601.3344225Pr-85
NRASup-regulatesTP53repressesR-3601.3344225Pr-85
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3601.3344225Pr-85
t(14;16)down-regulatesTP53repressesR-3601.3344225Pr-85
t(4;14)down-regulatesTP53repressesR-3601.3344225Pr-85
amp1qdown-regulatesTP53repressesR-3601.3344225Pr-85
del13down-regulatesTP53repressesR-3601.3344225Pr-85
t(4;14)_cytogeneticdown-regulatesTP53repressesR-3601.3344225Pr-85
MYO10down-regulatesELF2repressesR-977-1.4968210Pr-85
RNASeq_MAFA_Calldown-regulatesELF2repressesR-977-1.4968210Pr-85
DCHS1down-regulatesMZF1repressesR-30171.5427514Pr-85
DIS3down-regulatesMZF1repressesR-30171.5427514Pr-85
FAM46Cup-regulatesMZF1repressesR-30171.5427514Pr-85
NRASup-regulatesMZF1repressesR-30171.5427514Pr-85
RELNdown-regulatesMZF1repressesR-30171.5427514Pr-85
RNASeq_MAFA_Calldown-regulatesMZF1repressesR-30171.5427514Pr-85
t(14;16)down-regulatesMZF1repressesR-30171.5427514Pr-85
t(4;14)down-regulatesMZF1repressesR-30171.5427514Pr-85
TRIOdown-regulatesMZF1repressesR-30171.5427514Pr-85
amp1qdown-regulatesMZF1repressesR-30171.5427514Pr-85
del13down-regulatesMZF1repressesR-30171.5427514Pr-85
t(14;16)_cytogeneticdown-regulatesMZF1repressesR-30171.5427514Pr-85
t(4;14)_cytogeneticdown-regulatesMZF1repressesR-30171.5427514Pr-85
FGFR3down-regulatesCEBPDactivatesR-1311-1.668576Pr-85
PKHD1L1down-regulatesCEBPDactivatesR-1311-1.668576Pr-85
RNASeq_FGFR3_Calldown-regulatesCEBPDactivatesR-1311-1.668576Pr-85
t(4;14)down-regulatesCEBPDactivatesR-1311-1.668576Pr-85
ATMup-regulatesMYBactivatesR-622-1.9338Pr-85
CSMD1up-regulatesMYBactivatesR-622-1.9338Pr-85
KRASdown-regulatesMYBactivatesR-622-1.9338Pr-85
NRASdown-regulatesMYBactivatesR-622-1.9338Pr-85
PTPRDup-regulatesMYBactivatesR-622-1.9338Pr-85
RNASeq_MAFA_Callup-regulatesMYBactivatesR-622-1.9338Pr-85
RNASeq_MAFB_Callup-regulatesMYBactivatesR-622-1.9338Pr-85
t(14;16)up-regulatesMYBactivatesR-622-1.9338Pr-85
TRIOup-regulatesMYBactivatesR-622-1.9338Pr-85
amp1qup-regulatesMYBactivatesR-622-1.9338Pr-85
del13up-regulatesMYBactivatesR-622-1.9338Pr-85
t(14;16)_cytogeneticup-regulatesMYBactivatesR-622-1.9338Pr-85
CACNA1Hup-regulatesNR3C1activatesR-3187-2.3632614Pr-85
IRF4down-regulatesNR3C1activatesR-3187-2.3632614Pr-85
KIAA1244up-regulatesNR3C1activatesR-3187-2.3632614Pr-85
MYO10up-regulatesNR3C1activatesR-3187-2.3632614Pr-85
NRASdown-regulatesNR3C1activatesR-3187-2.3632614Pr-85
t(11;14)down-regulatesNR3C1activatesR-3187-2.3632614Pr-85
RNASeq_MAFA_Callup-regulatesNR3C1activatesR-3187-2.3632614Pr-85
RNASeq_MAFB_Callup-regulatesNR3C1activatesR-3187-2.3632614Pr-85
t(14;16)up-regulatesNR3C1activatesR-3187-2.3632614Pr-85
TRAF3up-regulatesNR3C1activatesR-3187-2.3632614Pr-85
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3187-2.3632614Pr-85
t(14;16)_cytogeneticup-regulatesNR3C1activatesR-3187-2.3632614Pr-85
MAXdown-regulatesMYCactivatesR-2071-2.719726Pr-85
t(11;14)down-regulatesMYCactivatesR-2071-2.719726Pr-85
NRASdown-regulatesTCF4activatesR-3002-3.038697Pr-85
t(11;14)down-regulatesTCF4activatesR-3002-3.038697Pr-85
TRAF3up-regulatesTCF4activatesR-3002-3.038697Pr-85
del13up-regulatesTCF4activatesR-3002-3.038697Pr-85
t(11;14)_cytogeneticdown-regulatesTCF4activatesR-3002-3.038697Pr-85
MACF1down-regulatesZNF281repressesR-2492-3.050728Pr-85
t(11;14)up-regulatesZNF281repressesR-2492-3.050728Pr-85
RNASeq_FGFR3_Callup-regulatesZNF281repressesR-2492-3.050728Pr-85
t(4;14)up-regulatesZNF281repressesR-2492-3.050728Pr-85

Regulons in program Pr-85

Regulon Cox Hazard Ratio # genes # causal flows
R-2966-0.066062468
R-4840.10927772
R-3159-0.213586158
R-597-0.298346185
R-6610.393644518
R-16880.5516772712
R-1272-0.568661712
R-23280.609176454
R-6150.6681491919
R-23660.8191111414
R-23740.9836471715
R-26471.03676287
R-3601.33442259
R-977-1.49682102
R-30171.542751413
R-1311-1.6685764
R-622-1.933812
R-3187-2.363261412
R-2071-2.7197262
R-3002-3.0386975
R-2492-3.0507284

Genes in program Pr-85

EnsEMBL IdEntrez IdPreferred
ENSG00000175899 2A2M
ENSG00000176248 29882ANAPC2
ENSG00000177453 167359NIM1K
ENSG00000178381 90637ZFAND2A
ENSG00000179562 79571GCC1
ENSG00000182150 375748ERCC6L2
ENSG00000182247 7325UBE2E2
ENSG00000182979 9112MTA1
ENSG00000183864 10766TOB2
ENSG00000185669 333929SNAI3
ENSG00000187994 126432RINL
ENSG00000188725 643155SMIM15
ENSG00000198203 6819SULT1C2
ENSG00000198952 23381SMG5
ENSG00000204070 90196SYS1
ENSG00000205643 150383CDPF1
ENSG00000221955 84561SLC12A8
ENSG00000259207 3690ITGB3

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions