Program

Causal Mechanistic Flows with regulons in program Pr-82

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Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
amp1q	up-regulates	EWSR1	activates	R-2560	2.38471	7	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
DMD	up-regulates	EWSR1	activates	R-2560	2.38471	7	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
FGFR3	up-regulates	ESRRG	represses	R-2436	2.04054	6	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
FRAS1	up-regulates	BORCS8-MEF2B	activates	R-963	2.55553	6	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
IRF4	up-regulates	BORCS8-MEF2B	activates	R-963	2.55553	6	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
RNASeq_FGFR3_Call	up-regulates	ESRRG	represses	R-2436	2.04054	6	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)	up-regulates	EWSR1	activates	R-2560	2.38471	7	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)	up-regulates	BORCS8-MEF2B	activates	R-963	2.55553	6	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)_cytogenetic	up-regulates	EWSR1	activates	R-2560	2.38471	7	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
t(11;14)_cytogenetic	up-regulates	BORCS8-MEF2B	activates	R-963	2.55553	6	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963

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Regulons in program Pr-82

Genes in program Pr-82