Program – Multiple Myeloma Network Portal

Causal Mechanistic Flows with regulons in program Pr-81

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
t(11;14)	down-regulates	ARID3A	activates	R-1351	2.72525	7	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFA_Call	up-regulates	ARID3A	activates	R-1351	2.72525	7	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(14;16)_cytogenetic	up-regulates	ARID3A	activates	R-1351	2.72525	7	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(11;14)	up-regulates	ELF1	represses	R-2993	3.17759	7	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
CYLD	up-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
FGFR3	down-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
NFKB2	up-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
PRKD2	down-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_FGFR3_Call	down-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFA_Call	up-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFB_Call	up-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(14;16)	up-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(4;14)	down-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
SYNE2	up-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(4;14)_cytogenetic	down-regulates	ETS1	activates	R-6	3.22139	8	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
MACF1	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFA_Call	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFB_Call	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(14;16)	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
ROBO2	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
SYNE2	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
TP53	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
del1p	up-regulates	MYB	activates	R-625	3.48247	6	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625

Regulons in program Pr-81

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-1351	2.72525	7	3
R-2993	3.17759	7	1
R-6	3.22139	8	11
R-625	3.48247	6	8

Pr-81

Program 81

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Regulons in program Pr-81

Genes in program Pr-81

Program Survival Plots