Program – Multiple Myeloma Network Portal

Causal Mechanistic Flows with regulons in program Pr-79

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
CMYA5	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
DIS3	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
DST	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
FAM46C	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
FGFR3	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
IRF4	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
MUC16	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
PRKD2	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(11;14)	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
RNASeq_FGFR3_Call	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
MYC	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(4;14)	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
SYNE1	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
UBR4	down-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(11;14)_cytogenetic	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(4;14)_cytogenetic	up-regulates	ZNF219	represses	R-2216	1.32424	7	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
NRAS	down-regulates	USF1	represses	R-1862	2.03502	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
RNASeq_CCND3_Call	up-regulates	USF1	represses	R-1862	2.03502	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
MYC	down-regulates	USF1	represses	R-1862	2.03502	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(4;14)	up-regulates	USF1	represses	R-1862	2.03502	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
TRAF3	up-regulates	USF1	represses	R-1862	2.03502	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(11;14)_cytogenetic	up-regulates	USF1	represses	R-1862	2.03502	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
DIS3	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
PRKD2	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(11;14)	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
RNASeq_CCND3_Call	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
RNASeq_FGFR3_Call	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(4;14)	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
SHANK1	down-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
SYNE1	down-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(11;14)_cytogenetic	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
t(4;14)_cytogenetic	up-regulates	TGIF1	represses	R-2507	2.17542	6	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507

Regulons in program Pr-79

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-2216	1.32424	7	16
R-1862	2.03502	6	6
R-2507	2.17542	6	10

Genes in program Pr-79

EnsEMBL Id	Entrez Id	Preferred
ENSG00000198087	23607	CD2AP
ENSG00000235568	150372	NFAM1
ENSG00000244687	7335	UBE2V1

Pr-79

Program 79

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Regulons in program Pr-79

Genes in program Pr-79

Program Survival Plots