Program

Causal Mechanistic Flows with regulons in program Pr-56

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesFOXP1repressesR-31340.064679218Pr-56
t(11;14)up-regulatesFOXP1repressesR-31340.064679218Pr-56
DCHS1down-regulatesENSG00000054598repressesR-10060.22705525Pr-56
PCLOdown-regulatesENSG00000054598repressesR-10060.22705525Pr-56
PTPRDdown-regulatesENSG00000054598repressesR-10060.22705525Pr-56
t(14;16)_cytogeneticdown-regulatesENSG00000054598repressesR-10060.22705525Pr-56
NRASup-regulatesIRF1repressesR-1900.3301124Pr-56
DCHS1down-regulatesELF3repressesR-21390.4418528Pr-56
DCHS1down-regulatesMEF2ArepressesR-18720.56105528Pr-56
FAM46Cup-regulatesMEF2ArepressesR-18720.56105528Pr-56
MAXdown-regulatesMEF2ArepressesR-18720.56105528Pr-56
NRASup-regulatesMEF2ArepressesR-18720.56105528Pr-56
PTPRDdown-regulatesMEF2ArepressesR-18720.56105528Pr-56
RNASeq_FGFR3_Calldown-regulatesMEF2ArepressesR-18720.56105528Pr-56
RNASeq_MAFB_Calldown-regulatesMEF2ArepressesR-18720.56105528Pr-56
t(4;14)down-regulatesMEF2ArepressesR-18720.56105528Pr-56
SYNE1down-regulatesMEF2ArepressesR-18720.56105528Pr-56
t(14;16)_cytogeneticdown-regulatesMEF2ArepressesR-18720.56105528Pr-56
MAXup-regulatesTCF3activatesR-20591.0262823Pr-56
AHNAK2down-regulatesEWSR1repressesR-25501.7205814Pr-56
PCDH10down-regulatesEWSR1repressesR-25501.7205814Pr-56
t(11;14)up-regulatesEWSR1repressesR-25501.7205814Pr-56
RNASeq_MAFB_Calldown-regulatesEWSR1repressesR-25501.7205814Pr-56

Regulons in program Pr-56

Regulon Cox Hazard Ratio # genes # causal flows
R-31340.0646792182
R-10060.227055254
R-1900.33011241
R-21390.44185281
R-18720.5610552810
R-20591.02628231
R-25501.72058144

Genes in program Pr-56

EnsEMBL IdEntrez IdPreferred
ENSG00000175866 10458BAIAP2
ENSG00000177556 475ATOX1
ENSG00000178741 9377COX5A
ENSG00000180398 90411MCFD2
ENSG00000182218
ENSG00000188554 4077NBR1
ENSG00000213337 51239ANKRD39

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions