Program

Causal Mechanistic Flows with regulons in program Pr-39

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3up-regulatesTFEBrepressesR-8890.02848886Pr-39
NEBdown-regulatesTFEBrepressesR-8890.02848886Pr-39
t(11;14)up-regulatesTFEBrepressesR-8890.02848886Pr-39
RNASeq_FGFR3_Callup-regulatesTFEBrepressesR-8890.02848886Pr-39
MYCdown-regulatesTFEBrepressesR-8890.02848886Pr-39
t(4;14)up-regulatesTFEBrepressesR-8890.02848886Pr-39
t(4;14)_cytogeneticup-regulatesTFEBrepressesR-8890.02848886Pr-39
CMYA5down-regulatesELK3repressesR-2846-0.04459858Pr-39
t(11;14)up-regulatesELK3repressesR-2846-0.04459858Pr-39
RNASeq_FGFR3_Callup-regulatesELK3repressesR-2846-0.04459858Pr-39
t(4;14)up-regulatesELK3repressesR-2846-0.04459858Pr-39
amp1qup-regulatesELK3repressesR-2846-0.04459858Pr-39
del13up-regulatesELK3repressesR-2846-0.04459858Pr-39
t(11;14)_cytogeneticup-regulatesELK3repressesR-2846-0.04459858Pr-39
t(4;14)_cytogeneticup-regulatesELK3repressesR-2846-0.04459858Pr-39
NEBdown-regulatesGABPB1repressesR-1954-0.3179176Pr-39
t(11;14)up-regulatesGABPB1repressesR-1954-0.3179176Pr-39
del13up-regulatesGABPB1repressesR-1954-0.3179176Pr-39
DIS3up-regulatesTFE3repressesR-558-0.319566Pr-39
NEBdown-regulatesTFE3repressesR-558-0.319566Pr-39
t(11;14)up-regulatesTFE3repressesR-558-0.319566Pr-39
RNASeq_FGFR3_Callup-regulatesTFE3repressesR-558-0.319566Pr-39
t(14;16)up-regulatesTFE3repressesR-558-0.319566Pr-39
MYCdown-regulatesTFE3repressesR-558-0.319566Pr-39
t(4;14)up-regulatesTFE3repressesR-558-0.319566Pr-39
TP53down-regulatesTFE3repressesR-558-0.319566Pr-39
amp1qup-regulatesTFE3repressesR-558-0.319566Pr-39
del13up-regulatesTFE3repressesR-558-0.319566Pr-39
t(4;14)_cytogeneticup-regulatesTFE3repressesR-558-0.319566Pr-39
FAT3down-regulatesELF3repressesR-2141-0.65501123Pr-39
t(11;14)up-regulatesELF3repressesR-2141-0.65501123Pr-39
TACC2down-regulatesELF3repressesR-2141-0.65501123Pr-39
TP53down-regulatesELF3repressesR-2141-0.65501123Pr-39
amp1qup-regulatesELF3repressesR-2141-0.65501123Pr-39
del13up-regulatesELF3repressesR-2141-0.65501123Pr-39
del17down-regulatesELF3repressesR-2141-0.65501123Pr-39
MYCdown-regulatesUSF1repressesR-1857-0.6864479Pr-39
t(4;14)up-regulatesUSF1repressesR-1857-0.6864479Pr-39
del13up-regulatesUSF1repressesR-1857-0.6864479Pr-39
RNASeq_FGFR3_Callup-regulatesETV6repressesR-708-0.87381111Pr-39
t(14;16)up-regulatesETV6repressesR-708-0.87381111Pr-39
t(4;14)up-regulatesETV6repressesR-708-0.87381111Pr-39
amp1qup-regulatesETV6repressesR-708-0.87381111Pr-39
del13up-regulatesETV6repressesR-708-0.87381111Pr-39
t(4;14)_cytogeneticup-regulatesETV6repressesR-708-0.87381111Pr-39
FGFR3down-regulatesTP53activatesR-378-1.069687Pr-39
PTPRDup-regulatesTP53activatesR-378-1.069687Pr-39
RNASeq_FGFR3_Calldown-regulatesTP53activatesR-378-1.069687Pr-39
t(4;14)down-regulatesTP53activatesR-378-1.069687Pr-39
SYNE1up-regulatesTP53activatesR-378-1.069687Pr-39
amp1qdown-regulatesTP53activatesR-378-1.069687Pr-39
del13down-regulatesTP53activatesR-378-1.069687Pr-39
t(4;14)_cytogeneticdown-regulatesTP53activatesR-378-1.069687Pr-39
t(11;14)down-regulatesARID3AactivatesR-1343-1.9389915Pr-39
DIS3down-regulatesEGR1activatesR-2900-2.2782411Pr-39
FGFR3down-regulatesEGR1activatesR-2900-2.2782411Pr-39
PRKD2down-regulatesEGR1activatesR-2900-2.2782411Pr-39
t(11;14)down-regulatesEGR1activatesR-2900-2.2782411Pr-39
RNASeq_FGFR3_Calldown-regulatesEGR1activatesR-2900-2.2782411Pr-39
t(4;14)down-regulatesEGR1activatesR-2900-2.2782411Pr-39
t(4;14)_cytogeneticdown-regulatesEGR1activatesR-2900-2.2782411Pr-39
KIAA1109down-regulatesTFCP2activatesR-1704-2.402876Pr-39
FGFR3up-regulatesELF4repressesR-2347-2.684114Pr-39
PRKD2up-regulatesELF4repressesR-2347-2.684114Pr-39
t(11;14)up-regulatesELF4repressesR-2347-2.684114Pr-39
RNASeq_FGFR3_Callup-regulatesELF4repressesR-2347-2.684114Pr-39
t(14;16)up-regulatesELF4repressesR-2347-2.684114Pr-39
del1pup-regulatesELF4repressesR-2347-2.684114Pr-39
KIAA1244down-regulatesELF1repressesR-2988-2.781269Pr-39
t(11;14)up-regulatesELF1repressesR-2988-2.781269Pr-39
t(11;14)_cytogeneticup-regulatesELF1repressesR-2988-2.781269Pr-39
NEBdown-regulatesEWSR1repressesR-2552-2.9946912Pr-39
t(11;14)up-regulatesEWSR1repressesR-2552-2.9946912Pr-39
RNASeq_FGFR3_Callup-regulatesEWSR1repressesR-2552-2.9946912Pr-39
t(14;16)up-regulatesEWSR1repressesR-2552-2.9946912Pr-39
t(4;14)up-regulatesEWSR1repressesR-2552-2.9946912Pr-39
amp1qup-regulatesEWSR1repressesR-2552-2.9946912Pr-39
del13up-regulatesEWSR1repressesR-2552-2.9946912Pr-39
t(11;14)_cytogeneticup-regulatesEWSR1repressesR-2552-2.9946912Pr-39
PRKD2down-regulatesCUX1activatesR-1245-4.8322210Pr-39
RNASeq_FGFR3_Calldown-regulatesCUX1activatesR-1245-4.8322210Pr-39
t(4;14)down-regulatesCUX1activatesR-1245-4.8322210Pr-39
amp1qdown-regulatesCUX1activatesR-1245-4.8322210Pr-39
BRAFup-regulatesBACH1repressesR-474-4.992147Pr-39
NEBdown-regulatesBACH1repressesR-474-4.992147Pr-39
t(11;14)up-regulatesBACH1repressesR-474-4.992147Pr-39
RNASeq_FGFR3_Callup-regulatesBACH1repressesR-474-4.992147Pr-39
t(14;16)up-regulatesBACH1repressesR-474-4.992147Pr-39
t(4;14)up-regulatesBACH1repressesR-474-4.992147Pr-39
amp1qup-regulatesBACH1repressesR-474-4.992147Pr-39
del13up-regulatesBACH1repressesR-474-4.992147Pr-39
t(11;14)up-regulatesFOSL1repressesR-2797-5.705597Pr-39

Regulons in program Pr-39

Regulon Cox Hazard Ratio # genes # causal flows
R-8890.028488867
R-2846-0.044598588
R-1954-0.31791763
R-558-0.31956611
R-2141-0.655011237
R-1857-0.68644793
R-708-0.873811116
R-378-1.0696878
R-1343-1.93899151
R-2900-2.27824117
R-1704-2.4028761
R-2347-2.6841146
R-2988-2.7812693
R-2552-2.99469128
R-1245-4.83222104
R-474-4.9921478
R-2797-5.7055971

Genes in program Pr-39

EnsEMBL IdEntrez IdPreferred
ENSG00000175575 80227PAAF1
ENSG00000175707 126695KDF1
ENSG00000178562 940CD28
ENSG00000178573 4094MAF
ENSG00000183735 29110TBK1
ENSG00000184207 283871PGP
ENSG00000186431 2204FCAR
ENSG00000189127
ENSG00000221963 80830APOL6
ENSG00000254415 100049587SIGLEC14
ENSG00000269028 100462981MTRNR2L2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions