Program

Causal Mechanistic Flows with regulons in program Pr-35

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
BRAFdown-regulatesESRRAactivatesR-27470.05013816Pr-35
DIS3down-regulatesESRRAactivatesR-27470.05013816Pr-35
FAM46Cup-regulatesESRRAactivatesR-27470.05013816Pr-35
MAXdown-regulatesESRRAactivatesR-27470.05013816Pr-35
RNASeq_FGFR3_Calldown-regulatesESRRAactivatesR-27470.05013816Pr-35
MYCup-regulatesESRRAactivatesR-27470.05013816Pr-35
t(4;14)down-regulatesESRRAactivatesR-27470.05013816Pr-35
TRIOdown-regulatesESRRAactivatesR-27470.05013816Pr-35
MAXup-regulatesXBP1repressesR-30590.3411638Pr-35
t(11;14)down-regulatesXBP1repressesR-30590.3411638Pr-35
MYCdown-regulatesXBP1repressesR-30590.3411638Pr-35
t(4;14)up-regulatesXBP1repressesR-30590.3411638Pr-35
t(11;14)_cytogeneticdown-regulatesXBP1repressesR-30590.3411638Pr-35
t(14;16)_cytogeneticup-regulatesXBP1repressesR-30590.3411638Pr-35
AHNAK2down-regulatesERFactivatesR-3360.3432626Pr-35
DIS3down-regulatesERFactivatesR-3360.3432626Pr-35
FAM46Cup-regulatesERFactivatesR-3360.3432626Pr-35
MACF1down-regulatesERFactivatesR-3360.3432626Pr-35
MAXdown-regulatesERFactivatesR-3360.3432626Pr-35
NRASup-regulatesERFactivatesR-3360.3432626Pr-35
PTPRDdown-regulatesERFactivatesR-3360.3432626Pr-35
RNASeq_FGFR3_Calldown-regulatesERFactivatesR-3360.3432626Pr-35
t(4;14)down-regulatesERFactivatesR-3360.3432626Pr-35
t(4;14)_cytogeneticdown-regulatesERFactivatesR-3360.3432626Pr-35
AHNAK2down-regulatesHINFPactivatesR-2624-0.448356Pr-35
DIS3down-regulatesHINFPactivatesR-2624-0.448356Pr-35
DNAH5down-regulatesHINFPactivatesR-2624-0.448356Pr-35
FAM46Cup-regulatesHINFPactivatesR-2624-0.448356Pr-35
FGFR3down-regulatesHINFPactivatesR-2624-0.448356Pr-35
MAXdown-regulatesHINFPactivatesR-2624-0.448356Pr-35
NRASup-regulatesHINFPactivatesR-2624-0.448356Pr-35
PRKD2down-regulatesHINFPactivatesR-2624-0.448356Pr-35
RNASeq_FGFR3_Calldown-regulatesHINFPactivatesR-2624-0.448356Pr-35
RNASeq_MAFA_Calldown-regulatesHINFPactivatesR-2624-0.448356Pr-35
t(14;16)down-regulatesHINFPactivatesR-2624-0.448356Pr-35
MYCup-regulatesHINFPactivatesR-2624-0.448356Pr-35
t(4;14)down-regulatesHINFPactivatesR-2624-0.448356Pr-35
TRIOdown-regulatesHINFPactivatesR-2624-0.448356Pr-35
amp1qdown-regulatesHINFPactivatesR-2624-0.448356Pr-35
del13down-regulatesHINFPactivatesR-2624-0.448356Pr-35
t(14;16)_cytogeneticdown-regulatesHINFPactivatesR-2624-0.448356Pr-35
t(4;14)_cytogeneticdown-regulatesHINFPactivatesR-2624-0.448356Pr-35
AHNAK2down-regulatesGABPB1activatesR-19480.5755679Pr-35
PTPRDdown-regulatesGABPB1activatesR-19480.5755679Pr-35
t(11;14)up-regulatesGABPB1activatesR-19480.5755679Pr-35
MAXdown-regulatesETS1activatesR-14-0.9141986Pr-35
RNASeq_CCND2_Calldown-regulatesETS1activatesR-14-0.9141986Pr-35
AHNAK2down-regulatesCREB1activatesR-277-1.544476Pr-35
CMYA5down-regulatesCREB1activatesR-277-1.544476Pr-35
DNAH5down-regulatesCREB1activatesR-277-1.544476Pr-35
FAT3down-regulatesCREB1activatesR-277-1.544476Pr-35
MAXdown-regulatesCREB1activatesR-277-1.544476Pr-35
PKHD1L1down-regulatesCREB1activatesR-277-1.544476Pr-35
RNASeq_CCND2_Calldown-regulatesCREB1activatesR-277-1.544476Pr-35
FGFR3down-regulatesPPARGactivatesR-2826-1.959710Pr-35
MUC12down-regulatesPPARGactivatesR-2826-1.959710Pr-35
RELNdown-regulatesPPARGactivatesR-2826-1.959710Pr-35
t(11;14)up-regulatesPPARGactivatesR-2826-1.959710Pr-35
RNASeq_FGFR3_Calldown-regulatesPPARGactivatesR-2826-1.959710Pr-35
t(14;16)down-regulatesPPARGactivatesR-2826-1.959710Pr-35
t(4;14)down-regulatesPPARGactivatesR-2826-1.959710Pr-35
SETD2down-regulatesPPARGactivatesR-2826-1.959710Pr-35
amp1qdown-regulatesPPARGactivatesR-2826-1.959710Pr-35
del13down-regulatesPPARGactivatesR-2826-1.959710Pr-35
t(14;16)_cytogeneticdown-regulatesPPARGactivatesR-2826-1.959710Pr-35
FAM46Cup-regulatesENSG00000168269activatesR-1570-2.109857Pr-35
PCLOdown-regulatesENSG00000168269activatesR-1570-2.109857Pr-35
PTPRDdown-regulatesENSG00000168269activatesR-1570-2.109857Pr-35
RNASeq_MAFB_Calldown-regulatesENSG00000168269activatesR-1570-2.109857Pr-35
TTNdown-regulatesENSG00000168269activatesR-1570-2.109857Pr-35
ZFHX3down-regulatesENSG00000168269activatesR-1570-2.109857Pr-35
AHNAK2down-regulatesIRF7activatesR-1094-2.511486Pr-35
FLGdown-regulatesIRF7activatesR-1094-2.511486Pr-35
RNASeq_FGFR3_Calldown-regulatesIRF7activatesR-1094-2.511486Pr-35
t(4;14)down-regulatesIRF7activatesR-1094-2.511486Pr-35
amp1qdown-regulatesIRF7activatesR-1094-2.511486Pr-35
t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1094-2.511486Pr-35
PRKD2down-regulatesCUX1activatesR-1244-2.639411Pr-35
RNASeq_FGFR3_Calldown-regulatesCUX1activatesR-1244-2.639411Pr-35
t(4;14)down-regulatesCUX1activatesR-1244-2.639411Pr-35
amp1qdown-regulatesCUX1activatesR-1244-2.639411Pr-35
AHNAK2down-regulatesHINFPactivatesR-2621-2.975059Pr-35
DIS3down-regulatesHINFPactivatesR-2621-2.975059Pr-35
FAM46Cup-regulatesHINFPactivatesR-2621-2.975059Pr-35
FAT3down-regulatesHINFPactivatesR-2621-2.975059Pr-35
FGFR3down-regulatesHINFPactivatesR-2621-2.975059Pr-35
IRF4down-regulatesHINFPactivatesR-2621-2.975059Pr-35
MACF1down-regulatesHINFPactivatesR-2621-2.975059Pr-35
MAXdown-regulatesHINFPactivatesR-2621-2.975059Pr-35
NRASup-regulatesHINFPactivatesR-2621-2.975059Pr-35
PRKD2down-regulatesHINFPactivatesR-2621-2.975059Pr-35
t(11;14)down-regulatesHINFPactivatesR-2621-2.975059Pr-35
RNASeq_FGFR3_Calldown-regulatesHINFPactivatesR-2621-2.975059Pr-35
RNASeq_MAFA_Calldown-regulatesHINFPactivatesR-2621-2.975059Pr-35
RNASeq_MAFB_Calldown-regulatesHINFPactivatesR-2621-2.975059Pr-35
t(14;16)down-regulatesHINFPactivatesR-2621-2.975059Pr-35
t(4;14)down-regulatesHINFPactivatesR-2621-2.975059Pr-35
TRAF3down-regulatesHINFPactivatesR-2621-2.975059Pr-35
TRIOdown-regulatesHINFPactivatesR-2621-2.975059Pr-35
del13down-regulatesHINFPactivatesR-2621-2.975059Pr-35
t(14;16)_cytogeneticdown-regulatesHINFPactivatesR-2621-2.975059Pr-35
t(4;14)_cytogeneticdown-regulatesHINFPactivatesR-2621-2.975059Pr-35
DIS3up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
FAT3up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
FGFR3up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
MACF1up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
MUC12up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
PTPRTup-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
RELNup-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
t(11;14)down-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
RNASeq_FGFR3_Callup-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
t(14;16)up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
t(4;14)up-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
amp1qup-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
t(11;14)_cytogeneticdown-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
t(4;14)_cytogeneticup-regulatesZBTB7BrepressesR-1232-2.985598Pr-35
AHNAK2down-regulatesTRIM28activatesR-1506-3.37096Pr-35
DSTdown-regulatesTRIM28activatesR-1506-3.37096Pr-35
MACF1down-regulatesTRIM28activatesR-1506-3.37096Pr-35
RELNdown-regulatesTRIM28activatesR-1506-3.37096Pr-35
t(14;16)down-regulatesTRIM28activatesR-1506-3.37096Pr-35
TRAF3down-regulatesTRIM28activatesR-1506-3.37096Pr-35
TTNdown-regulatesTRIM28activatesR-1506-3.37096Pr-35
amp1qdown-regulatesTRIM28activatesR-1506-3.37096Pr-35
del13down-regulatesTRIM28activatesR-1506-3.37096Pr-35
t(14;16)_cytogeneticdown-regulatesTRIM28activatesR-1506-3.37096Pr-35
DCHS1down-regulatesMZF1activatesR-3019-3.4224412Pr-35
DIS3down-regulatesMZF1activatesR-3019-3.4224412Pr-35
FAM46Cup-regulatesMZF1activatesR-3019-3.4224412Pr-35
FAT3down-regulatesMZF1activatesR-3019-3.4224412Pr-35
FGFR3down-regulatesMZF1activatesR-3019-3.4224412Pr-35
IRF4down-regulatesMZF1activatesR-3019-3.4224412Pr-35
MAXdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
NRASup-regulatesMZF1activatesR-3019-3.4224412Pr-35
PRKD2down-regulatesMZF1activatesR-3019-3.4224412Pr-35
RELNdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
t(11;14)down-regulatesMZF1activatesR-3019-3.4224412Pr-35
RNASeq_FGFR3_Calldown-regulatesMZF1activatesR-3019-3.4224412Pr-35
RNASeq_MAFA_Calldown-regulatesMZF1activatesR-3019-3.4224412Pr-35
t(14;16)down-regulatesMZF1activatesR-3019-3.4224412Pr-35
t(4;14)down-regulatesMZF1activatesR-3019-3.4224412Pr-35
SETD2down-regulatesMZF1activatesR-3019-3.4224412Pr-35
TRIOdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
amp1qdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
del13down-regulatesMZF1activatesR-3019-3.4224412Pr-35
t(11;14)_cytogeneticdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
t(14;16)_cytogeneticdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
t(4;14)_cytogeneticdown-regulatesMZF1activatesR-3019-3.4224412Pr-35
DIS3down-regulatesIRF4activatesR-493-3.474897Pr-35
FAM46Cup-regulatesIRF4activatesR-493-3.474897Pr-35
FRAS1down-regulatesIRF4activatesR-493-3.474897Pr-35
MAXdown-regulatesIRF4activatesR-493-3.474897Pr-35
PKHD1L1down-regulatesIRF4activatesR-493-3.474897Pr-35
PRKD2down-regulatesIRF4activatesR-493-3.474897Pr-35
t(11;14)down-regulatesIRF4activatesR-493-3.474897Pr-35
RNASeq_CCND2_Calldown-regulatesIRF4activatesR-493-3.474897Pr-35
RNASeq_FGFR3_Calldown-regulatesIRF4activatesR-493-3.474897Pr-35
t(4;14)down-regulatesIRF4activatesR-493-3.474897Pr-35
amp1qdown-regulatesIRF4activatesR-493-3.474897Pr-35
del13down-regulatesIRF4activatesR-493-3.474897Pr-35
t(4;14)_cytogeneticdown-regulatesIRF4activatesR-493-3.474897Pr-35
AHNAK2down-regulatesGABPB1activatesR-1945-3.7181612Pr-35
FAT3down-regulatesGABPB1activatesR-1945-3.7181612Pr-35
RNASeq_MAFA_Calldown-regulatesGABPB1activatesR-1945-3.7181612Pr-35
TACC2down-regulatesGABPB1activatesR-1945-3.7181612Pr-35
DIS3down-regulatesKLF16activatesR-2691-3.8316916Pr-35
FGFR3down-regulatesKLF16activatesR-2691-3.8316916Pr-35
NRASup-regulatesKLF16activatesR-2691-3.8316916Pr-35
t(11;14)down-regulatesKLF16activatesR-2691-3.8316916Pr-35
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2691-3.8316916Pr-35
t(4;14)down-regulatesKLF16activatesR-2691-3.8316916Pr-35
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2691-3.8316916Pr-35
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2691-3.8316916Pr-35
AHNAK2down-regulatesSPDEFactivatesR-1963-4.2322912Pr-35
IRF4down-regulatesSPDEFactivatesR-1963-4.2322912Pr-35
t(11;14)down-regulatesSPDEFactivatesR-1963-4.2322912Pr-35
RNASeq_MAFB_Calldown-regulatesSPDEFactivatesR-1963-4.2322912Pr-35
SETD2down-regulatesSPDEFactivatesR-1963-4.2322912Pr-35
AHNAK2down-regulatesZEB1activatesR-2244-4.4708713Pr-35
EYSup-regulatesZEB1activatesR-2244-4.4708713Pr-35
t(11;14)down-regulatesZEB1activatesR-2244-4.4708713Pr-35

Regulons in program Pr-35

Regulon Cox Hazard Ratio # genes # causal flows
R-27470.050138168
R-30590.34116386
R-3360.343262610
R-2624-0.44835618
R-19480.57556793
R-14-0.91419862
R-277-1.5444767
R-2826-1.95971011
R-1570-2.1098576
R-1094-2.5114866
R-1244-2.6394114
R-2621-2.97505921
R-1232-2.98559814
R-1506-3.3709610
R-3019-3.422441222
R-493-3.47489713
R-1945-3.71816124
R-2691-3.83169168
R-1963-4.23229125
R-2244-4.47087133

Genes in program Pr-35

EnsEMBL IdEntrez IdPreferred
ENSG00000175745
ENSG00000178951 51341ZBTB7A
ENSG00000179029 84314TMEM107
ENSG00000180535 168620BHLHA15
ENSG00000182327 388323GLTPD2
ENSG00000186918 55893ZNF395
ENSG00000204103 9935MAFB
ENSG00000224531 221710SMIM13
ENSG00000241978 11217AKAP2
ENSG00000170608 3171FOX3A

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions