Program

Causal Mechanistic Flows with regulons in program Pr-33

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
BAI3down-regulatesFOXO1activatesR-14150.26596212Pr-33
FAT3down-regulatesFOXO1activatesR-14150.26596212Pr-33
KDM3Bdown-regulatesFOXO1activatesR-14150.26596212Pr-33
NEBdown-regulatesFOXO1activatesR-14150.26596212Pr-33
SVILdown-regulatesFOXO1activatesR-14150.26596212Pr-33
del13up-regulatesFOXO1activatesR-14150.26596212Pr-33
BAI3down-regulatesELF4activatesR-23490.27748611Pr-33
DNAH10up-regulatesELF4activatesR-23490.27748611Pr-33
FGFR3up-regulatesELF4activatesR-23490.27748611Pr-33
PRDM1up-regulatesELF4activatesR-23490.27748611Pr-33
PRKD2up-regulatesELF4activatesR-23490.27748611Pr-33
RNASeq_FGFR3_Callup-regulatesELF4activatesR-23490.27748611Pr-33
ABCA13down-regulatesFOXJ3activatesR-28930.53686712Pr-33
DNAH5down-regulatesFOXJ3activatesR-28930.53686712Pr-33
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-28930.53686712Pr-33
t(4;14)up-regulatesFOXJ3activatesR-28930.53686712Pr-33
amp1qup-regulatesFOXJ3activatesR-28930.53686712Pr-33
del13up-regulatesFOXJ3activatesR-28930.53686712Pr-33
FAT3down-regulatesELF3activatesR-21470.53686712Pr-33
KALRNdown-regulatesELF3activatesR-21470.53686712Pr-33
amp1qup-regulatesELF3activatesR-21470.53686712Pr-33
del13up-regulatesELF3activatesR-21470.53686712Pr-33
TRAF3down-regulatesENSG00000054598activatesR-10140.61029411Pr-33
DNAH5down-regulatesNFATC1activatesR-22050.947497Pr-33
IRF4up-regulatesNFATC1activatesR-22050.947497Pr-33
PRKD2up-regulatesNFATC1activatesR-22050.947497Pr-33
RNASeq_CCND2_Calldown-regulatesNFATC1activatesR-22050.947497Pr-33
del13up-regulatesNFATC1activatesR-22050.947497Pr-33

Regulons in program Pr-33

Regulon Cox Hazard Ratio # genes # causal flows
R-14150.265962126
R-23490.277486116
R-28930.536867126
R-21470.536867124
R-10140.610294111
R-22050.9474975

Genes in program Pr-33

EnsEMBL IdEntrez IdPreferred
ENSG00000177842 253639ZNF620
ENSG00000178035 3615IMPDH2
ENSG00000181830 55343SLC35C1
ENSG00000181847 201633TIGIT
ENSG00000183020 161AP2A2
ENSG00000187479 387763C11orf96

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions