Program

Causal Mechanistic Flows with regulons in program Pr-31

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DMDup-regulatesFOXP1activatesR-31350.5846315Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

amp1qup-regulatesFOXP1activatesR-31350.5846315Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

del13up-regulatesFOXP1activatesR-31350.5846315Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

RNASeq_FGFR3_Calldown-regulatesZNF740repressesR-3940.9893616Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

t(4;14)down-regulatesZNF740repressesR-3940.9893616Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

amp1qdown-regulatesZNF740repressesR-3940.9893616Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

del13down-regulatesZNF740repressesR-3940.9893616Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

t(4;14)_cytogeneticdown-regulatesZNF740repressesR-3940.9893616Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

PTPRDdown-regulatesHBP1activatesR-18361.0088412Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

SYNE1down-regulatesHBP1activatesR-18361.0088412Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

amp1qup-regulatesHBP1activatesR-18361.0088412Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

del13up-regulatesHBP1activatesR-18361.0088412Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

DIS3up-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

FGFR3up-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

GPR98down-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

LTBup-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

NRASdown-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

PRKD2up-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

RNASeq_FGFR3_Callup-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

MYCdown-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

t(4;14)up-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

amp1qup-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

del13up-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

t(4;14)_cytogeneticup-regulatesKLF4activatesR-27571.832527Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

Regulons in program Pr-31

Regulon Cox Hazard Ratio # genes # causal flows
R-31350.58463153
R-3940.98936165
R-18361.00884124
R-27571.83252712

Genes in program Pr-31

EnsEMBL IdEntrez IdPreferred
ENSG00000182670 7267TTC3
ENSG00000188042 10123ARL4C
ENSG00000188342 2963GTF2F2
ENSG00000214706 7866IFRD2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions