Program

Causal Mechanistic Flows with regulons in program Pr-25

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesELF2activatesR-9740.12249811Pr-25
FAT3down-regulatesELF2activatesR-9740.12249811Pr-25
KALRNdown-regulatesELF2activatesR-9740.12249811Pr-25
MACF1down-regulatesELF2activatesR-9740.12249811Pr-25
NEBdown-regulatesELF2activatesR-9740.12249811Pr-25
RNASeq_MAFA_Calldown-regulatesELF2activatesR-9740.12249811Pr-25
DNAH5down-regulatesNFIL3activatesR-1686-0.1457046Pr-25
FAT3down-regulatesNFIL3activatesR-1686-0.1457046Pr-25
MAXdown-regulatesNFIL3activatesR-1686-0.1457046Pr-25
NRASup-regulatesNFIL3activatesR-1686-0.1457046Pr-25
t(11;14)up-regulatesNFIL3activatesR-1686-0.1457046Pr-25
RNASeq_MAFB_Calldown-regulatesNFIL3activatesR-1686-0.1457046Pr-25
TRAF3down-regulatesNFIL3activatesR-1686-0.1457046Pr-25
del17down-regulatesNFIL3activatesR-1686-0.1457046Pr-25
AHNAK2down-regulatesRARAactivatesR-160-0.33189412Pr-25
DNAH5down-regulatesRARAactivatesR-160-0.33189412Pr-25
MACF1down-regulatesRARAactivatesR-160-0.33189412Pr-25
MAXdown-regulatesRARAactivatesR-160-0.33189412Pr-25
NEBdown-regulatesRARAactivatesR-160-0.33189412Pr-25
PCDH7down-regulatesRARAactivatesR-160-0.33189412Pr-25
t(11;14)up-regulatesRARAactivatesR-160-0.33189412Pr-25
t(11;14)_cytogeneticup-regulatesRARAactivatesR-160-0.33189412Pr-25
t(14;16)up-regulatesETV6activatesR-7090.3562911Pr-25
ABCA13up-regulatesZNF143repressesR-23120.425349Pr-25
MACF1up-regulatesZNF143repressesR-23120.425349Pr-25
RNASeq_MAFA_Callup-regulatesZNF143repressesR-23120.425349Pr-25
AHNAK2down-regulatesELF1activatesR-2984-0.58139513Pr-25
NRASup-regulatesELF1activatesR-2984-0.58139513Pr-25
t(11;14)up-regulatesELF1activatesR-2984-0.58139513Pr-25
TRAF3down-regulatesELF1activatesR-2984-0.58139513Pr-25
t(11;14)_cytogeneticup-regulatesELF1activatesR-2984-0.58139513Pr-25
AHNAK2down-regulatesELF4activatesR-2341-1.2001318Pr-25
PRDM1up-regulatesELF4activatesR-2341-1.2001318Pr-25
t(11;14)up-regulatesELF4activatesR-2341-1.2001318Pr-25
TRAF3down-regulatesELF4activatesR-2341-1.2001318Pr-25
AHNAK2down-regulatesMAFKactivatesR-2802-1.6027217Pr-25
FAT3down-regulatesMAFKactivatesR-2802-1.6027217Pr-25
KALRNdown-regulatesMAFKactivatesR-2802-1.6027217Pr-25
MACF1down-regulatesMAFKactivatesR-2802-1.6027217Pr-25
NEBdown-regulatesMAFKactivatesR-2802-1.6027217Pr-25
RNASeq_MAFA_Calldown-regulatesMAFKactivatesR-2802-1.6027217Pr-25
DNAH5up-regulatesXBP1repressesR-3062-2.117266Pr-25
IRF4down-regulatesXBP1repressesR-3062-2.117266Pr-25
NEBup-regulatesXBP1repressesR-3062-2.117266Pr-25
t(11;14)down-regulatesXBP1repressesR-3062-2.117266Pr-25

Regulons in program Pr-25

Regulon Cox Hazard Ratio # genes # causal flows
R-9740.122498116
R-1686-0.14570468
R-160-0.331894128
R-7090.35629111
R-23120.4253493
R-2984-0.581395135
R-2341-1.20013184
R-2802-1.60272176
R-3062-2.1172664

Genes in program Pr-25

EnsEMBL IdEntrez IdPreferred
ENSG00000176393 6051RNPEP
ENSG00000176783 80230RUFY1
ENSG00000178773
ENSG00000179195 144348ZNF664
ENSG00000180098 54952TRNAU1AP
ENSG00000182566 339390CLEC4G
ENSG00000197122 6714SRC
ENSG00000204642 3134HLA-F
ENSG00000242732 340526RTL5

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions