Program

Causal Mechanistic Flows with regulons in program Pr-21

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(4;14)up-regulatesUSF1activatesR-18600.6714336Pr-21
del13up-regulatesUSF1activatesR-18600.6714336Pr-21
t(11;14)_cytogeneticup-regulatesUSF1activatesR-18600.6714336Pr-21
t(11;14)down-regulatesMGArepressesR-11730.724666Pr-21
t(14;16)down-regulatesMGArepressesR-11730.724666Pr-21
AHNAK2down-regulatesELF2activatesR-9820.821898Pr-21
MYO10down-regulatesELF2activatesR-9820.821898Pr-21
NEBdown-regulatesELF2activatesR-9820.821898Pr-21
PCDH10down-regulatesELF2activatesR-9820.821898Pr-21
RNASeq_MAFA_Calldown-regulatesELF2activatesR-9820.821898Pr-21
amp1qup-regulatesELF2activatesR-9820.821898Pr-21
del13up-regulatesELF2activatesR-9820.821898Pr-21
AHNAK2down-regulatesHBP1activatesR-18430.8936828Pr-21
t(11;14)up-regulatesHBP1activatesR-18430.8936828Pr-21
SYNE1down-regulatesHBP1activatesR-18430.8936828Pr-21
amp1qup-regulatesHBP1activatesR-18430.8936828Pr-21
del13up-regulatesHBP1activatesR-18430.8936828Pr-21
AHNAK2down-regulatesFOXO1activatesR-14091.7797215Pr-21
ASXL3down-regulatesFOXO1activatesR-14091.7797215Pr-21
MYO10down-regulatesFOXO1activatesR-14091.7797215Pr-21
PTPRDdown-regulatesFOXO1activatesR-14091.7797215Pr-21
t(11;14)up-regulatesFOXO1activatesR-14091.7797215Pr-21
RNASeq_MAFA_Calldown-regulatesFOXO1activatesR-14091.7797215Pr-21
del13up-regulatesFOXO1activatesR-14091.7797215Pr-21
t(14;16)down-regulatesTCF3repressesR-20641.8570418Pr-21
AHNAK2down-regulatesRFX3activatesR-16691.973178Pr-21
MYO10down-regulatesRFX3activatesR-16691.973178Pr-21
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-16691.973178Pr-21
t(4;14)up-regulatesRFX3activatesR-16691.973178Pr-21
t(4;14)_cytogeneticup-regulatesRFX3activatesR-16691.973178Pr-21
AHNAK2down-regulatesMEF2AactivatesR-18812.3945717Pr-21
MYO10down-regulatesMEF2AactivatesR-18812.3945717Pr-21
PTPRDdown-regulatesMEF2AactivatesR-18812.3945717Pr-21
RNASeq_MAFA_Calldown-regulatesMEF2AactivatesR-18812.3945717Pr-21
SYNE1down-regulatesMEF2AactivatesR-18812.3945717Pr-21
amp1qup-regulatesMEF2AactivatesR-18812.3945717Pr-21
del13up-regulatesMEF2AactivatesR-18812.3945717Pr-21
AHNAK2down-regulatesCEBPGactivatesR-4452.5386710Pr-21
MYO10down-regulatesCEBPGactivatesR-4452.5386710Pr-21
PCDH10down-regulatesCEBPGactivatesR-4452.5386710Pr-21
PTPRDdown-regulatesCEBPGactivatesR-4452.5386710Pr-21
RNASeq_MAFA_Calldown-regulatesCEBPGactivatesR-4452.5386710Pr-21
SYNE1down-regulatesCEBPGactivatesR-4452.5386710Pr-21
amp1qup-regulatesCEBPGactivatesR-4452.5386710Pr-21
del13up-regulatesCEBPGactivatesR-4452.5386710Pr-21
AHNAK2down-regulatesHBP1activatesR-18372.5729811Pr-21
MYO10down-regulatesHBP1activatesR-18372.5729811Pr-21
PCDH10down-regulatesHBP1activatesR-18372.5729811Pr-21
PTPRDdown-regulatesHBP1activatesR-18372.5729811Pr-21
t(11;14)up-regulatesHBP1activatesR-18372.5729811Pr-21
SYNE1down-regulatesHBP1activatesR-18372.5729811Pr-21
amp1qup-regulatesHBP1activatesR-18372.5729811Pr-21
del13up-regulatesHBP1activatesR-18372.5729811Pr-21
BRAFup-regulatesBACH1activatesR-4762.93217Pr-21
MYO10down-regulatesBACH1activatesR-4762.93217Pr-21
NEBdown-regulatesBACH1activatesR-4762.93217Pr-21
PCDH10down-regulatesBACH1activatesR-4762.93217Pr-21
t(11;14)up-regulatesBACH1activatesR-4762.93217Pr-21
RNASeq_FGFR3_Callup-regulatesBACH1activatesR-4762.93217Pr-21
t(14;16)up-regulatesBACH1activatesR-4762.93217Pr-21
t(4;14)up-regulatesBACH1activatesR-4762.93217Pr-21
amp1qup-regulatesBACH1activatesR-4762.93217Pr-21
del13up-regulatesBACH1activatesR-4762.93217Pr-21
t(11;14)_cytogeneticup-regulatesBACH1activatesR-4762.93217Pr-21
ATMup-regulatesMAFGactivatesR-14943.017787Pr-21
BRAFup-regulatesMAFGactivatesR-14943.017787Pr-21
t(11;14)up-regulatesMAFGactivatesR-14943.017787Pr-21
t(14;16)up-regulatesMAFGactivatesR-14943.017787Pr-21
t(4;14)up-regulatesMAFGactivatesR-14943.017787Pr-21
amp1qup-regulatesMAFGactivatesR-14943.017787Pr-21
del13up-regulatesMAFGactivatesR-14943.017787Pr-21
t(4;14)_cytogeneticup-regulatesMAFGactivatesR-14943.017787Pr-21
DIS3up-regulatesMEF2DactivatesR-8733.153239Pr-21
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8733.153239Pr-21
t(14;16)up-regulatesMEF2DactivatesR-8733.153239Pr-21
t(4;14)up-regulatesMEF2DactivatesR-8733.153239Pr-21
amp1qup-regulatesMEF2DactivatesR-8733.153239Pr-21
del13up-regulatesMEF2DactivatesR-8733.153239Pr-21

Regulons in program Pr-21

Regulon Cox Hazard Ratio # genes # causal flows
R-18600.67143363
R-11730.7246662
R-9820.8218987
R-18430.89368285
R-14091.77972157
R-20641.85704181
R-16691.9731785
R-18812.39457177
R-4452.53867108
R-18372.57298118
R-4762.9321711
R-14943.0177878
R-8733.1532396

Genes in program Pr-21

EnsEMBL IdEntrez IdPreferred
ENSG00000183955 387893KMT5A
ENSG00000184602 8303SNN
ENSG00000185745 3434IFIT1
ENSG00000186660 80829ZFP91
ENSG00000213988 7643ZNF90
ENSG00000215472 100526842RPL17-C18orf32
ENSG00000225663 348262MCRIP1
ENSG00000267680 7767ZNF224

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions