Program

Causal Mechanistic Flows with regulons in program Pr-20

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesRREB1activatesR-2300-0.6463338Pr-20
MACF1down-regulatesRREB1activatesR-2300-0.6463338Pr-20
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2300-0.6463338Pr-20
RNASeq_MAFA_Calldown-regulatesRREB1activatesR-2300-0.6463338Pr-20
RNASeq_MAFB_Calldown-regulatesRREB1activatesR-2300-0.6463338Pr-20
t(4;14)down-regulatesRREB1activatesR-2300-0.6463338Pr-20
TACC2down-regulatesRREB1activatesR-2300-0.6463338Pr-20
t(4;14)_cytogeneticdown-regulatesRREB1activatesR-2300-0.6463338Pr-20
FGFR3down-regulatesEGR1activatesR-2901-0.9118469Pr-20
KDM3Bdown-regulatesEGR1activatesR-2901-0.9118469Pr-20
MAXdown-regulatesEGR1activatesR-2901-0.9118469Pr-20
RNASeq_FGFR3_Calldown-regulatesEGR1activatesR-2901-0.9118469Pr-20
t(4;14)down-regulatesEGR1activatesR-2901-0.9118469Pr-20
t(4;14)_cytogeneticdown-regulatesEGR1activatesR-2901-0.9118469Pr-20
KIAA1109up-regulatesZNF410activatesR-1936-1.6554510Pr-20
ROBO1up-regulatesZNF410activatesR-1936-1.6554510Pr-20
AHNAK2up-regulatesSP1repressesR-2733-2.2094314Pr-20
DCHS1up-regulatesSP1repressesR-2733-2.2094314Pr-20
DIS3up-regulatesSP1repressesR-2733-2.2094314Pr-20
FAM46Cdown-regulatesSP1repressesR-2733-2.2094314Pr-20
FGFR3up-regulatesSP1repressesR-2733-2.2094314Pr-20
PTPRDup-regulatesSP1repressesR-2733-2.2094314Pr-20
RNASeq_FGFR3_Callup-regulatesSP1repressesR-2733-2.2094314Pr-20
RNASeq_MAFA_Callup-regulatesSP1repressesR-2733-2.2094314Pr-20
RNASeq_MAFB_Callup-regulatesSP1repressesR-2733-2.2094314Pr-20
t(14;16)up-regulatesSP1repressesR-2733-2.2094314Pr-20
t(4;14)up-regulatesSP1repressesR-2733-2.2094314Pr-20
SVILup-regulatesSP1repressesR-2733-2.2094314Pr-20
TRAF3up-regulatesSP1repressesR-2733-2.2094314Pr-20
UBR4up-regulatesSP1repressesR-2733-2.2094314Pr-20
t(14;16)_cytogeneticup-regulatesSP1repressesR-2733-2.2094314Pr-20
t(4;14)_cytogeneticup-regulatesSP1repressesR-2733-2.2094314Pr-20
AHNAK2down-regulatesELF2activatesR-987-2.344968Pr-20
FAT3down-regulatesELF2activatesR-987-2.344968Pr-20
MACF1down-regulatesELF2activatesR-987-2.344968Pr-20
MAGI1down-regulatesELF2activatesR-987-2.344968Pr-20
PTPRDdown-regulatesELF2activatesR-987-2.344968Pr-20
RNASeq_MAFA_Calldown-regulatesELF2activatesR-987-2.344968Pr-20
SYNE1down-regulatesELF2activatesR-987-2.344968Pr-20
AHNAK2down-regulatesRREB1activatesR-2297-2.57119Pr-20
CMYA5down-regulatesRREB1activatesR-2297-2.57119Pr-20
FAT3down-regulatesRREB1activatesR-2297-2.57119Pr-20
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2297-2.57119Pr-20
RNASeq_MAFB_Calldown-regulatesRREB1activatesR-2297-2.57119Pr-20
t(4;14)down-regulatesRREB1activatesR-2297-2.57119Pr-20
t(4;14)_cytogeneticdown-regulatesRREB1activatesR-2297-2.57119Pr-20
AHNAK2down-regulatesNR3C1activatesR-3189-3.276712Pr-20
FAT3down-regulatesNR3C1activatesR-3189-3.276712Pr-20
MAXdown-regulatesNR3C1activatesR-3189-3.276712Pr-20
t(4;14)_cytogeneticdown-regulatesNR3C1activatesR-3189-3.276712Pr-20
AHNAK2down-regulatesRARAactivatesR-166-3.6015410Pr-20
DNAH5down-regulatesRARAactivatesR-166-3.6015410Pr-20
MAGI1down-regulatesRARAactivatesR-166-3.6015410Pr-20
MAXdown-regulatesRARAactivatesR-166-3.6015410Pr-20
TACC2down-regulatesRARAactivatesR-166-3.6015410Pr-20
TP53down-regulatesRARAactivatesR-166-3.6015410Pr-20
t(14;16)_cytogeneticdown-regulatesRARAactivatesR-166-3.6015410Pr-20
AHNAK2up-regulatesSP1repressesR-2726-3.8205219Pr-20
DCHS1up-regulatesSP1repressesR-2726-3.8205219Pr-20
DIS3up-regulatesSP1repressesR-2726-3.8205219Pr-20
FAT3up-regulatesSP1repressesR-2726-3.8205219Pr-20
FGFR3up-regulatesSP1repressesR-2726-3.8205219Pr-20
PTPRDup-regulatesSP1repressesR-2726-3.8205219Pr-20
RNASeq_FGFR3_Callup-regulatesSP1repressesR-2726-3.8205219Pr-20
RNASeq_MAFA_Callup-regulatesSP1repressesR-2726-3.8205219Pr-20
RNASeq_MAFB_Callup-regulatesSP1repressesR-2726-3.8205219Pr-20
t(4;14)up-regulatesSP1repressesR-2726-3.8205219Pr-20
SVILup-regulatesSP1repressesR-2726-3.8205219Pr-20
TRAF3up-regulatesSP1repressesR-2726-3.8205219Pr-20
TRIOup-regulatesSP1repressesR-2726-3.8205219Pr-20
UBR4up-regulatesSP1repressesR-2726-3.8205219Pr-20
amp1qup-regulatesSP1repressesR-2726-3.8205219Pr-20
t(14;16)_cytogeneticup-regulatesSP1repressesR-2726-3.8205219Pr-20
t(4;14)_cytogeneticup-regulatesSP1repressesR-2726-3.8205219Pr-20
AHNAK2down-regulatesZNF281activatesR-2484-3.9135512Pr-20
CMYA5down-regulatesZNF281activatesR-2484-3.9135512Pr-20
FAT3down-regulatesZNF281activatesR-2484-3.9135512Pr-20
NEBdown-regulatesZNF281activatesR-2484-3.9135512Pr-20
t(11;14)up-regulatesZNF281activatesR-2484-3.9135512Pr-20
SYNE1down-regulatesZNF281activatesR-2484-3.9135512Pr-20
TACC2down-regulatesZNF281activatesR-2484-3.9135512Pr-20
t(11;14)_cytogeneticup-regulatesZNF281activatesR-2484-3.9135512Pr-20

Regulons in program Pr-20

Regulon Cox Hazard Ratio # genes # causal flows
R-2300-0.64633388
R-2901-0.91184696
R-1936-1.65545102
R-2733-2.209431416
R-987-2.3449687
R-2297-2.571197
R-3189-3.2767124
R-166-3.60154107
R-2726-3.820521917
R-2484-3.91355128

Genes in program Pr-20

EnsEMBL IdEntrez IdPreferred
ENSG00000183647 348327ZNF530
ENSG00000186871 54821ERCC6L
ENSG00000205531 4676NAP1L4
ENSG00000249471 388569ZNF324B
ENSG00000258818 6038RNASE4

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions