Program

Causal Mechanistic Flows with regulons in program Pr-126

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
LRP1Bdown-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
MUC12down-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
PCLOdown-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
t(11;14)up-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
t(14;16)down-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
MYCdown-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
TRAF3down-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
amp1qdown-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
t(14;16)_cytogeneticdown-regulatesCEBPDactivatesR-1312-0.4408346Pr-126
DIS3up-regulatesENSG00000162367activatesR-17100.91675213Pr-126
DNAH10up-regulatesENSG00000162367activatesR-17100.91675213Pr-126
LRP2down-regulatesENSG00000162367activatesR-17100.91675213Pr-126
NEBdown-regulatesENSG00000162367activatesR-17100.91675213Pr-126
PCLOdown-regulatesENSG00000162367activatesR-17100.91675213Pr-126
t(11;14)up-regulatesENSG00000162367activatesR-17100.91675213Pr-126
t(11;14)_cytogeneticup-regulatesENSG00000162367activatesR-17100.91675213Pr-126
t(14;16)_cytogeneticdown-regulatesENSG00000162367activatesR-17100.91675213Pr-126
FAM46Cdown-regulatesNF1activatesR-1280.9649357Pr-126
IRF4up-regulatesNF1activatesR-1280.9649357Pr-126
LRP2down-regulatesNF1activatesR-1280.9649357Pr-126
PCLOdown-regulatesNF1activatesR-1280.9649357Pr-126
t(11;14)up-regulatesNF1activatesR-1280.9649357Pr-126
SP140down-regulatesNF1activatesR-1280.9649357Pr-126
t(11;14)_cytogeneticup-regulatesNF1activatesR-1280.9649357Pr-126
t(14;16)_cytogeneticdown-regulatesNF1activatesR-1280.9649357Pr-126
FAM46Cup-regulatesTP53repressesR-3661.4635112Pr-126
FGFR3down-regulatesTP53repressesR-3661.4635112Pr-126
NRASup-regulatesTP53repressesR-3661.4635112Pr-126
PTPRDup-regulatesTP53repressesR-3661.4635112Pr-126
t(11;14)down-regulatesTP53repressesR-3661.4635112Pr-126
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3661.4635112Pr-126
MYCup-regulatesTP53repressesR-3661.4635112Pr-126
t(4;14)down-regulatesTP53repressesR-3661.4635112Pr-126
SYNE1up-regulatesTP53repressesR-3661.4635112Pr-126
t(4;14)_cytogeneticdown-regulatesTP53repressesR-3661.4635112Pr-126
KIAA1244down-regulatesSPI1activatesR-26121.7016119Pr-126
LRP1Bdown-regulatesSPI1activatesR-26121.7016119Pr-126
LRP2down-regulatesSPI1activatesR-26121.7016119Pr-126
NEBdown-regulatesSPI1activatesR-26121.7016119Pr-126
t(11;14)up-regulatesSPI1activatesR-26121.7016119Pr-126
MYCdown-regulatesSPI1activatesR-26121.7016119Pr-126
TRAF3down-regulatesSPI1activatesR-26121.7016119Pr-126
t(14;16)_cytogeneticdown-regulatesSPI1activatesR-26121.7016119Pr-126
t(11;14)up-regulatesFOXJ2activatesR-14421.7263216Pr-126
t(4;14)up-regulatesFOXJ2activatesR-14421.7263216Pr-126
FAT3down-regulatesELF2activatesR-9812.072798Pr-126
NEBdown-regulatesELF2activatesR-9812.072798Pr-126
del13up-regulatesELF2activatesR-9812.072798Pr-126
FAM46Cup-regulatesESRRArepressesR-27392.1308313Pr-126
FGFR3down-regulatesESRRArepressesR-27392.1308313Pr-126
IRF4down-regulatesESRRArepressesR-27392.1308313Pr-126
KIAA1244up-regulatesESRRArepressesR-27392.1308313Pr-126
MUC16up-regulatesESRRArepressesR-27392.1308313Pr-126
NRASup-regulatesESRRArepressesR-27392.1308313Pr-126
PRKD2down-regulatesESRRArepressesR-27392.1308313Pr-126
t(11;14)down-regulatesESRRArepressesR-27392.1308313Pr-126
RNASeq_FGFR3_Calldown-regulatesESRRArepressesR-27392.1308313Pr-126
MYCup-regulatesESRRArepressesR-27392.1308313Pr-126
t(4;14)down-regulatesESRRArepressesR-27392.1308313Pr-126
t(11;14)_cytogeneticdown-regulatesESRRArepressesR-27392.1308313Pr-126
t(4;14)_cytogeneticdown-regulatesESRRArepressesR-27392.1308313Pr-126
COL6A5down-regulatesENSG00000245848activatesR-16472.1853914Pr-126
KIAA1244down-regulatesENSG00000245848activatesR-16472.1853914Pr-126
LRP1Bdown-regulatesENSG00000245848activatesR-16472.1853914Pr-126
LRP2down-regulatesENSG00000245848activatesR-16472.1853914Pr-126
NEBdown-regulatesENSG00000245848activatesR-16472.1853914Pr-126
PCLOdown-regulatesENSG00000245848activatesR-16472.1853914Pr-126
t(11;14)up-regulatesENSG00000245848activatesR-16472.1853914Pr-126
MYCdown-regulatesENSG00000245848activatesR-16472.1853914Pr-126
TRAF3down-regulatesENSG00000245848activatesR-16472.1853914Pr-126
t(14;16)_cytogeneticdown-regulatesENSG00000245848activatesR-16472.1853914Pr-126
FAM46Cdown-regulatesCEBPBactivatesR-1766-2.1854211Pr-126
IRF4up-regulatesCEBPBactivatesR-1766-2.1854211Pr-126
PRKD2up-regulatesCEBPBactivatesR-1766-2.1854211Pr-126
t(11;14)up-regulatesCEBPBactivatesR-1766-2.1854211Pr-126
TTNdown-regulatesCEBPBactivatesR-1766-2.1854211Pr-126
t(11;14)_cytogeneticup-regulatesCEBPBactivatesR-1766-2.1854211Pr-126
LRP1Bdown-regulatesBCL6activatesR-5422.2142917Pr-126
NEBdown-regulatesBCL6activatesR-5422.2142917Pr-126
t(11;14)up-regulatesBCL6activatesR-5422.2142917Pr-126
MYCdown-regulatesBCL6activatesR-5422.2142917Pr-126
t(14;16)_cytogeneticdown-regulatesBCL6activatesR-5422.2142917Pr-126
LRP1Bdown-regulatesENSG00000123405activatesR-26722.249768Pr-126
LRP2down-regulatesENSG00000123405activatesR-26722.249768Pr-126
NEBdown-regulatesENSG00000123405activatesR-26722.249768Pr-126
t(11;14)up-regulatesENSG00000123405activatesR-26722.249768Pr-126
MYCdown-regulatesENSG00000123405activatesR-26722.249768Pr-126
t(14;16)_cytogeneticdown-regulatesENSG00000123405activatesR-26722.249768Pr-126
NEBdown-regulatesEWSR1activatesR-25433.0324337Pr-126
t(11;14)up-regulatesEWSR1activatesR-25433.0324337Pr-126
RNASeq_FGFR3_Callup-regulatesEWSR1activatesR-25433.0324337Pr-126
t(14;16)up-regulatesEWSR1activatesR-25433.0324337Pr-126
t(4;14)up-regulatesEWSR1activatesR-25433.0324337Pr-126
SYNE1down-regulatesEWSR1activatesR-25433.0324337Pr-126
amp1qup-regulatesEWSR1activatesR-25433.0324337Pr-126
del13up-regulatesEWSR1activatesR-25433.0324337Pr-126
t(11;14)_cytogeneticup-regulatesEWSR1activatesR-25433.0324337Pr-126
DNAH5up-regulatesPARP1repressesR-26383.032839Pr-126
t(11;14)down-regulatesPARP1repressesR-26383.032839Pr-126
t(11;14)_cytogeneticdown-regulatesPARP1repressesR-26383.032839Pr-126
NEBup-regulatesXBP1repressesR-30533.2536410Pr-126
t(11;14)down-regulatesXBP1repressesR-30533.2536410Pr-126
RNASeq_MAFA_Calldown-regulatesXBP1repressesR-30533.2536410Pr-126
del1pdown-regulatesXBP1repressesR-30533.2536410Pr-126

Regulons in program Pr-126

Regulon Cox Hazard Ratio # genes # causal flows
R-1312-0.44083469
R-17100.916752138
R-1280.96493578
R-3661.463511210
R-26121.70161198
R-14421.72632162
R-9812.0727983
R-27392.130831313
R-16472.185391410
R-1766-2.18542116
R-5422.21429175
R-26722.2497686
R-25433.03243379
R-26383.0328393
R-30533.25364104

Genes in program Pr-126

EnsEMBL IdEntrez IdPreferred
ENSG00000180354 222166MTURN
ENSG00000187033 344658SAMD7
ENSG00000187608 9636ISG15
ENSG00000198874 55253TYW1
ENSG00000213064 375035SFT2D2
ENSG00000213402 5790PTPRCAP
ENSG00000239713 60489APOBEC3G
ENSG00000243147 9553MRPL33
ENSG00000248333 984CDK11B
ENSG00000248405 553158PRR5-ARHGAP8
ENSG00000249961 283847TERB1
ENSG00000253797 9724UTP14C

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions