Program

Causal Mechanistic Flows with regulons in program Pr-122

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3up-regulatesZNF219activatesR-2218-0.3209986Pr-122
DSTdown-regulatesZNF219activatesR-2218-0.3209986Pr-122
FGFR3up-regulatesZNF219activatesR-2218-0.3209986Pr-122
MUC16down-regulatesZNF219activatesR-2218-0.3209986Pr-122
PRKD2up-regulatesZNF219activatesR-2218-0.3209986Pr-122
RNASeq_FGFR3_Callup-regulatesZNF219activatesR-2218-0.3209986Pr-122
t(4;14)up-regulatesZNF219activatesR-2218-0.3209986Pr-122
t(4;14)_cytogeneticup-regulatesZNF219activatesR-2218-0.3209986Pr-122
CYLDup-regulatesTRAF4repressesR-3042-0.3424686Pr-122
NRASup-regulatesTRAF4repressesR-3042-0.3424686Pr-122
t(11;14)up-regulatesTRAF4repressesR-3042-0.3424686Pr-122
RNASeq_FGFR3_Calldown-regulatesTRAF4repressesR-3042-0.3424686Pr-122
t(4;14)down-regulatesTRAF4repressesR-3042-0.3424686Pr-122
TRAF3down-regulatesTRAF4repressesR-3042-0.3424686Pr-122
t(4;14)_cytogeneticdown-regulatesTRAF4repressesR-3042-0.3424686Pr-122
DIS3up-regulatesTGIF1activatesR-25010.5875458Pr-122
DNAH10up-regulatesTGIF1activatesR-25010.5875458Pr-122
DUSP2down-regulatesTGIF1activatesR-25010.5875458Pr-122
KMT2Bdown-regulatesTGIF1activatesR-25010.5875458Pr-122
PRKD2up-regulatesTGIF1activatesR-25010.5875458Pr-122
t(11;14)up-regulatesTGIF1activatesR-25010.5875458Pr-122
RNASeq_FGFR3_Callup-regulatesTGIF1activatesR-25010.5875458Pr-122
RNASeq_MAFA_Callup-regulatesTGIF1activatesR-25010.5875458Pr-122
t(14;16)up-regulatesTGIF1activatesR-25010.5875458Pr-122
t(4;14)up-regulatesTGIF1activatesR-25010.5875458Pr-122
ROBO2up-regulatesTGIF1activatesR-25010.5875458Pr-122
SHANK1down-regulatesTGIF1activatesR-25010.5875458Pr-122
SLIT2down-regulatesTGIF1activatesR-25010.5875458Pr-122
t(11;14)_cytogeneticup-regulatesTGIF1activatesR-25010.5875458Pr-122
t(4;14)_cytogeneticup-regulatesTGIF1activatesR-25010.5875458Pr-122
ATMup-regulatesSMAD3repressesR-2962-0.59290210Pr-122
CACNA1Hup-regulatesSMAD3repressesR-2962-0.59290210Pr-122
FLGup-regulatesSMAD3repressesR-2962-0.59290210Pr-122
KRASdown-regulatesSMAD3repressesR-2962-0.59290210Pr-122
RNASeq_MAFA_Callup-regulatesSMAD3repressesR-2962-0.59290210Pr-122
RNASeq_MAFB_Callup-regulatesSMAD3repressesR-2962-0.59290210Pr-122
t(14;16)up-regulatesSMAD3repressesR-2962-0.59290210Pr-122
SYNE2up-regulatesSMAD3repressesR-2962-0.59290210Pr-122
t(14;16)_cytogeneticup-regulatesSMAD3repressesR-2962-0.59290210Pr-122
DSTdown-regulatesSATB1activatesR-10781.151229Pr-122
FGFR3up-regulatesSATB1activatesR-10781.151229Pr-122
PRKD2up-regulatesSATB1activatesR-10781.151229Pr-122
RNASeq_CCND2_Calldown-regulatesSATB1activatesR-10781.151229Pr-122
RNASeq_FGFR3_Callup-regulatesSATB1activatesR-10781.151229Pr-122
t(4;14)up-regulatesSATB1activatesR-10781.151229Pr-122
RYR1down-regulatesSATB1activatesR-10781.151229Pr-122
t(4;14)_cytogeneticup-regulatesSATB1activatesR-10781.151229Pr-122
FGFR3up-regulatesENSG00000176887activatesR-19001.87516Pr-122
PRKD2up-regulatesENSG00000176887activatesR-19001.87516Pr-122
RNASeq_FGFR3_Callup-regulatesENSG00000176887activatesR-19001.87516Pr-122
t(4;14)up-regulatesENSG00000176887activatesR-19001.87516Pr-122
TP53up-regulatesENSG00000176887activatesR-19001.87516Pr-122
t(4;14)_cytogeneticup-regulatesENSG00000176887activatesR-19001.87516Pr-122
FGFR3up-regulatesARID5BactivatesR-10982.614896Pr-122
RNASeq_FGFR3_Callup-regulatesARID5BactivatesR-10982.614896Pr-122
t(4;14)up-regulatesARID5BactivatesR-10982.614896Pr-122
t(4;14)_cytogeneticup-regulatesARID5BactivatesR-10982.614896Pr-122
RNASeq_MAFA_Calldown-regulatesMAFKrepressesR-28122.916758Pr-122
COL6A5down-regulatesSTAT5AactivatesR-21683.102597Pr-122
DIS3up-regulatesSTAT5AactivatesR-21683.102597Pr-122
FGFR3up-regulatesSTAT5AactivatesR-21683.102597Pr-122
IRF4up-regulatesSTAT5AactivatesR-21683.102597Pr-122
KIAA1244down-regulatesSTAT5AactivatesR-21683.102597Pr-122
t(11;14)up-regulatesSTAT5AactivatesR-21683.102597Pr-122
RNASeq_MAFA_Callup-regulatesSTAT5AactivatesR-21683.102597Pr-122
t(14;16)up-regulatesSTAT5AactivatesR-21683.102597Pr-122
t(4;14)up-regulatesSTAT5AactivatesR-21683.102597Pr-122
amp1qup-regulatesSTAT5AactivatesR-21683.102597Pr-122
del1pup-regulatesSTAT5AactivatesR-21683.102597Pr-122
t(11;14)_cytogeneticup-regulatesSTAT5AactivatesR-21683.102597Pr-122
t(4;14)_cytogeneticup-regulatesSTAT5AactivatesR-21683.102597Pr-122
DIS3up-regulatesENSG00000162367activatesR-17123.183819Pr-122
DNAH10up-regulatesENSG00000162367activatesR-17123.183819Pr-122
t(11;14)up-regulatesENSG00000162367activatesR-17123.183819Pr-122
del1pup-regulatesENSG00000162367activatesR-17123.183819Pr-122
t(11;14)up-regulatesENSG00000138795activatesR-273.202297Pr-122
TP53up-regulatesENSG00000138795activatesR-273.202297Pr-122
COL6A5down-regulatesHLXactivatesR-27603.3984723Pr-122
FGFR3up-regulatesHLXactivatesR-27603.3984723Pr-122
LRP2down-regulatesHLXactivatesR-27603.3984723Pr-122
MUC16down-regulatesHLXactivatesR-27603.3984723Pr-122
PRKD2up-regulatesHLXactivatesR-27603.3984723Pr-122
t(11;14)up-regulatesHLXactivatesR-27603.3984723Pr-122
RNASeq_FGFR3_Callup-regulatesHLXactivatesR-27603.3984723Pr-122
t(4;14)up-regulatesHLXactivatesR-27603.3984723Pr-122
XIRP2down-regulatesHLXactivatesR-27603.3984723Pr-122
t(4;14)_cytogeneticup-regulatesHLXactivatesR-27603.3984723Pr-122
DIS3up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
DNAH10up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
FAM46Cdown-regulatesENSG00000176887activatesR-18923.4298911Pr-122
FGFR3up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
IRF4up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
MAXup-regulatesENSG00000176887activatesR-18923.4298911Pr-122
PRKD2up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
t(11;14)up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
RNASeq_FGFR3_Callup-regulatesENSG00000176887activatesR-18923.4298911Pr-122
t(14;16)up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
t(4;14)up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
TP53up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
amp1qup-regulatesENSG00000176887activatesR-18923.4298911Pr-122
del13up-regulatesENSG00000176887activatesR-18923.4298911Pr-122
t(11;14)_cytogeneticup-regulatesENSG00000176887activatesR-18923.4298911Pr-122
t(4;14)_cytogeneticup-regulatesENSG00000176887activatesR-18923.4298911Pr-122
DNAH10up-regulatesSPIBactivatesR-6803.461176Pr-122
NRASdown-regulatesSPIBactivatesR-6803.461176Pr-122
RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6803.461176Pr-122
t(4;14)up-regulatesSPIBactivatesR-6803.461176Pr-122
del1pup-regulatesSPIBactivatesR-6803.461176Pr-122
DNAH10up-regulatesSTAT5BactivatesR-23703.574696Pr-122
FGFR3up-regulatesSTAT5BactivatesR-23703.574696Pr-122
MACF1up-regulatesSTAT5BactivatesR-23703.574696Pr-122
NRASdown-regulatesSTAT5BactivatesR-23703.574696Pr-122
PRDM1up-regulatesSTAT5BactivatesR-23703.574696Pr-122
RNASeq_FGFR3_Callup-regulatesSTAT5BactivatesR-23703.574696Pr-122
RNASeq_MAFA_Callup-regulatesSTAT5BactivatesR-23703.574696Pr-122
t(4;14)up-regulatesSTAT5BactivatesR-23703.574696Pr-122
TP53up-regulatesSTAT5BactivatesR-23703.574696Pr-122
del17up-regulatesSTAT5BactivatesR-23703.574696Pr-122
del17pup-regulatesSTAT5BactivatesR-23703.574696Pr-122
del1pup-regulatesSTAT5BactivatesR-23703.574696Pr-122
t(14;16)_cytogeneticup-regulatesSTAT5BactivatesR-23703.574696Pr-122
t(4;14)_cytogeneticup-regulatesSTAT5BactivatesR-23703.574696Pr-122
HIST1H1Eup-regulatesCUX1repressesR-12483.672167Pr-122
PRKD2down-regulatesCUX1repressesR-12483.672167Pr-122
RNASeq_FGFR3_Calldown-regulatesCUX1repressesR-12483.672167Pr-122
t(4;14)down-regulatesCUX1repressesR-12483.672167Pr-122
NRASdown-regulatesNFATC2activatesR-16933.739710Pr-122
RNASeq_MAFA_Callup-regulatesNFATC2activatesR-16933.739710Pr-122
RNASeq_MAFB_Callup-regulatesNFATC2activatesR-16933.739710Pr-122
t(14;16)up-regulatesNFATC2activatesR-16933.739710Pr-122
amp1qup-regulatesNFATC2activatesR-16933.739710Pr-122
del13up-regulatesNFATC2activatesR-16933.739710Pr-122
del1pup-regulatesNFATC2activatesR-16933.739710Pr-122
DIS3up-regulatesYY1activatesR-25253.9180710Pr-122
DNAH10up-regulatesYY1activatesR-25253.9180710Pr-122
DUSP2down-regulatesYY1activatesR-25253.9180710Pr-122
FGFR3up-regulatesYY1activatesR-25253.9180710Pr-122
LTBup-regulatesYY1activatesR-25253.9180710Pr-122
MUC16down-regulatesYY1activatesR-25253.9180710Pr-122
PRKD2up-regulatesYY1activatesR-25253.9180710Pr-122
RNASeq_FGFR3_Callup-regulatesYY1activatesR-25253.9180710Pr-122
RNASeq_MAFA_Callup-regulatesYY1activatesR-25253.9180710Pr-122
t(4;14)up-regulatesYY1activatesR-25253.9180710Pr-122
TP53up-regulatesYY1activatesR-25253.9180710Pr-122
del13up-regulatesYY1activatesR-25253.9180710Pr-122
t(4;14)_cytogeneticup-regulatesYY1activatesR-25253.9180710Pr-122
t(11;14)up-regulatesENSG00000123405activatesR-26733.98967Pr-122
DIS3up-regulatesCEBPBactivatesR-17724.020478Pr-122
FAM46Cdown-regulatesCEBPBactivatesR-17724.020478Pr-122
FGFR3up-regulatesCEBPBactivatesR-17724.020478Pr-122
IRF4up-regulatesCEBPBactivatesR-17724.020478Pr-122
LTBup-regulatesCEBPBactivatesR-17724.020478Pr-122
NRASdown-regulatesCEBPBactivatesR-17724.020478Pr-122
PRKD2up-regulatesCEBPBactivatesR-17724.020478Pr-122
RELNup-regulatesCEBPBactivatesR-17724.020478Pr-122
t(11;14)up-regulatesCEBPBactivatesR-17724.020478Pr-122
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-17724.020478Pr-122
t(4;14)up-regulatesCEBPBactivatesR-17724.020478Pr-122
SETD2up-regulatesCEBPBactivatesR-17724.020478Pr-122
t(11;14)_cytogeneticup-regulatesCEBPBactivatesR-17724.020478Pr-122
t(4;14)_cytogeneticup-regulatesCEBPBactivatesR-17724.020478Pr-122
COL6A5down-regulatesENSG00000175745activatesR-5194.704277Pr-122
DIS3up-regulatesENSG00000175745activatesR-5194.704277Pr-122
FGFR3up-regulatesENSG00000175745activatesR-5194.704277Pr-122
PRKD2up-regulatesENSG00000175745activatesR-5194.704277Pr-122
RNASeq_FGFR3_Callup-regulatesENSG00000175745activatesR-5194.704277Pr-122
t(4;14)up-regulatesENSG00000175745activatesR-5194.704277Pr-122
del13up-regulatesENSG00000175745activatesR-5194.704277Pr-122
t(4;14)_cytogeneticup-regulatesENSG00000175745activatesR-5194.704277Pr-122

Regulons in program Pr-122

Regulon Cox Hazard Ratio # genes # causal flows
R-2218-0.32099868
R-3042-0.34246867
R-25010.587545815
R-2962-0.592902109
R-10781.1512298
R-19001.875166
R-10982.6148964
R-28122.9167581
R-21683.10259713
R-17123.1838194
R-273.2022972
R-27603.398472310
R-18923.429891116
R-6803.4611765
R-23703.57469614
R-12483.6721674
R-16933.7397107
R-25253.918071013
R-26733.989671
R-17724.02047814
R-5194.7042778

Genes in program Pr-122

EnsEMBL IdEntrez IdPreferred
ENSG00000178694 63899NSUN3
ENSG00000178982 27335EIF3K
ENSG00000182718 302ANXA2
ENSG00000182866 3932LCK
ENSG00000196664 51284TLR7
ENSG00000217930 51025PAM16

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions