Program

Causal Mechanistic Flows with regulons in program Pr-12

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FGFR3up-regulatesCREB5activatesR-7760.1453027Pr-12
LTBup-regulatesCREB5activatesR-7760.1453027Pr-12
PRKD2up-regulatesCREB5activatesR-7760.1453027Pr-12
RNASeq_FGFR3_Callup-regulatesCREB5activatesR-7760.1453027Pr-12
t(4;14)up-regulatesCREB5activatesR-7760.1453027Pr-12
amp1qup-regulatesCREB5activatesR-7760.1453027Pr-12
del13up-regulatesCREB5activatesR-7760.1453027Pr-12
t(4;14)_cytogeneticup-regulatesCREB5activatesR-7760.1453027Pr-12
KIAA1109down-regulatesJUNrepressesR-1187-0.2377136Pr-12
t(11;14)up-regulatesJUNrepressesR-1187-0.2377136Pr-12
t(11;14)_cytogeneticup-regulatesJUNrepressesR-1187-0.2377136Pr-12
NRASdown-regulatesNR3C1activatesR-3181-0.55761819Pr-12
PRDM1up-regulatesNR3C1activatesR-3181-0.55761819Pr-12
t(11;14)down-regulatesNR3C1activatesR-3181-0.55761819Pr-12
t(14;16)up-regulatesNR3C1activatesR-3181-0.55761819Pr-12
del13up-regulatesNR3C1activatesR-3181-0.55761819Pr-12
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3181-0.55761819Pr-12
MAGI1down-regulatesBCL6activatesR-555-0.7603527Pr-12
FAT3down-regulatesELF3activatesR-2154-0.7603527Pr-12
amp1qup-regulatesELF3activatesR-2154-0.7603527Pr-12
del13up-regulatesELF3activatesR-2154-0.7603527Pr-12
FGFR3up-regulatesSOX4activatesR-2189-0.7769266Pr-12
KDM3Bdown-regulatesSOX4activatesR-2189-0.7769266Pr-12
LTBup-regulatesSOX4activatesR-2189-0.7769266Pr-12
NRASdown-regulatesSOX4activatesR-2189-0.7769266Pr-12
t(11;14)down-regulatesSOX4activatesR-2189-0.7769266Pr-12
RNASeq_FGFR3_Callup-regulatesSOX4activatesR-2189-0.7769266Pr-12
RNASeq_MAFA_Calldown-regulatesSOX4activatesR-2189-0.7769266Pr-12
t(4;14)up-regulatesSOX4activatesR-2189-0.7769266Pr-12
del13up-regulatesSOX4activatesR-2189-0.7769266Pr-12
t(11;14)_cytogeneticdown-regulatesSOX4activatesR-2189-0.7769266Pr-12
ASXL3down-regulatesFOXJ2activatesR-1434-1.1547527Pr-12
MAGEC1down-regulatesFOXJ2activatesR-1434-1.1547527Pr-12
t(14;16)up-regulatesFOXJ2activatesR-1434-1.1547527Pr-12
t(4;14)up-regulatesFOXJ2activatesR-1434-1.1547527Pr-12
amp1qup-regulatesFOXJ2activatesR-1434-1.1547527Pr-12
del13up-regulatesFOXJ2activatesR-1434-1.1547527Pr-12
FGFR3up-regulatesIRF1activatesR-189-1.2823625Pr-12
PRDM1up-regulatesIRF1activatesR-189-1.2823625Pr-12
PRKD2up-regulatesIRF1activatesR-189-1.2823625Pr-12
RNASeq_FGFR3_Callup-regulatesIRF1activatesR-189-1.2823625Pr-12
t(14;16)up-regulatesIRF1activatesR-189-1.2823625Pr-12
PRDM1up-regulatesFOXP1activatesR-3127-1.2965827Pr-12
t(14;16)up-regulatesFOXP1activatesR-3127-1.2965827Pr-12
amp1qup-regulatesFOXP1activatesR-3127-1.2965827Pr-12
del13up-regulatesFOXP1activatesR-3127-1.2965827Pr-12
t(11;14)down-regulatesZEB1activatesR-2242-1.3852914Pr-12
t(14;16)up-regulatesZEB1activatesR-2242-1.3852914Pr-12
amp1qup-regulatesZEB1activatesR-2242-1.3852914Pr-12
del13up-regulatesZEB1activatesR-2242-1.3852914Pr-12
t(11;14)_cytogeneticdown-regulatesZEB1activatesR-2242-1.3852914Pr-12
ASXL3down-regulatesFOXO1activatesR-1403-1.3857725Pr-12
FAT3down-regulatesFOXO1activatesR-1403-1.3857725Pr-12
KDM3Bdown-regulatesFOXO1activatesR-1403-1.3857725Pr-12
del13up-regulatesFOXO1activatesR-1403-1.3857725Pr-12
HUWE1down-regulatesKLF7activatesR-281-1.5449712Pr-12
MAGEC1down-regulatesKLF7activatesR-281-1.5449712Pr-12
NRASdown-regulatesKLF7activatesR-281-1.5449712Pr-12
t(11;14)down-regulatesKLF7activatesR-281-1.5449712Pr-12
MYCdown-regulatesKLF7activatesR-281-1.5449712Pr-12
ROBO1up-regulatesKLF7activatesR-281-1.5449712Pr-12
SYNE1down-regulatesKLF7activatesR-281-1.5449712Pr-12
TP53down-regulatesKLF7activatesR-281-1.5449712Pr-12
ZNF462down-regulatesKLF7activatesR-281-1.5449712Pr-12
amp1qup-regulatesKLF7activatesR-281-1.5449712Pr-12
del13up-regulatesKLF7activatesR-281-1.5449712Pr-12
t(11;14)_cytogeneticdown-regulatesKLF7activatesR-281-1.5449712Pr-12
KDM3Bdown-regulatesRREB1activatesR-2291-1.620716Pr-12
MXRA5down-regulatesRREB1activatesR-2291-1.620716Pr-12
SYNE1down-regulatesRREB1activatesR-2291-1.620716Pr-12
TP53down-regulatesRREB1activatesR-2291-1.620716Pr-12
ZNF462down-regulatesRREB1activatesR-2291-1.620716Pr-12
t(11;14)up-regulatesFOSrepressesR-2193-2.012986Pr-12
t(14;16)down-regulatesFOSrepressesR-2193-2.012986Pr-12
ROBO1down-regulatesFOSrepressesR-2193-2.012986Pr-12
amp1qdown-regulatesFOSrepressesR-2193-2.012986Pr-12
del13down-regulatesFOSrepressesR-2193-2.012986Pr-12
HUWE1up-regulatesBRCA1repressesR-1033-2.583756Pr-12
t(11;14)up-regulatesBRCA1repressesR-1033-2.583756Pr-12
TP53up-regulatesBRCA1repressesR-1033-2.583756Pr-12
t(11;14)_cytogeneticup-regulatesBRCA1repressesR-1033-2.583756Pr-12
KIAA1244up-regulatesUSF1activatesR-1861-2.671286Pr-12
NRASdown-regulatesUSF1activatesR-1861-2.671286Pr-12
t(4;14)up-regulatesUSF1activatesR-1861-2.671286Pr-12
del13up-regulatesUSF1activatesR-1861-2.671286Pr-12
t(11;14)down-regulatesZEB1activatesR-2245-3.1091811Pr-12
t(14;16)up-regulatesZEB1activatesR-2245-3.1091811Pr-12
amp1qup-regulatesZEB1activatesR-2245-3.1091811Pr-12
del13up-regulatesZEB1activatesR-2245-3.1091811Pr-12

Regulons in program Pr-12

Regulon Cox Hazard Ratio # genes # causal flows
R-7760.14530278
R-1187-0.23771363
R-3181-0.557618196
R-555-0.76035271
R-2154-0.76035273
R-2189-0.776926610
R-1434-1.15475276
R-189-1.28236255
R-3127-1.29658274
R-2242-1.38529145
R-1403-1.38577254
R-281-1.544971212
R-2291-1.6207165
R-2193-2.0129865
R-1033-2.5837564
R-1861-2.6712864
R-2245-3.10918114

Genes in program Pr-12

EnsEMBL IdEntrez IdPreferred
ENSG00000176749 8851CDK5R1
ENSG00000177576 497661C18orf32
ENSG00000182196 51329ARL6IP4
ENSG00000185049 7469NELFA
ENSG00000185085 80789INTS5
ENSG00000185222 51186TCEAL9
ENSG00000196705 170959ZNF431
ENSG00000197779 347344ZNF81
ENSG00000197872 81553FAM49A
ENSG00000198520 339541ARMH1
ENSG00000198535 145741C2CD4A
ENSG00000204120 26058GIGYF2
ENSG00000204991 84501SPIRE2
ENSG00000232112 51372TMA7

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions