Program

Causal Mechanistic Flows with regulons in program Pr-115

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesELF4activatesR-2348-2.8301212Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

BAI3down-regulatesELF4activatesR-2348-2.8301212Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

DNAH10up-regulatesELF4activatesR-2348-2.8301212Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

FGFR3up-regulatesELF4activatesR-2348-2.8301212Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

PRKD2up-regulatesELF4activatesR-2348-2.8301212Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_FGFR3_Callup-regulatesELF4activatesR-2348-2.8301212Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

AHNAK2down-regulatesFOXK1activatesR-1201-2.9373511Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

PTPRDdown-regulatesFOXK1activatesR-1201-2.9373511Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_MAFA_Calldown-regulatesFOXK1activatesR-1201-2.9373511Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(4;14)up-regulatesFOXK1activatesR-1201-2.9373511Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

SYNE1down-regulatesFOXK1activatesR-1201-2.9373511Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(11;14)up-regulatesBORCS8-MEF2BrepressesR-962-3.113276Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_CCND2_Callup-regulatesBORCS8-MEF2BrepressesR-962-3.113276Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

SDK1up-regulatesBORCS8-MEF2BrepressesR-962-3.113276Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(11;14)_cytogeneticup-regulatesBORCS8-MEF2BrepressesR-962-3.113276Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

AHNAK2down-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

BAI3down-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

KDM3Bdown-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

PTPRDdown-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_MAFA_Calldown-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_MAFB_Calldown-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

del13up-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(14;16)_cytogeneticdown-regulatesFOXO1activatesR-1413-3.3365213Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

AHNAK2down-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

BRAFdown-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

DIS3down-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(11;14)down-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_CCND2_Calldown-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(14;16)down-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(11;14)_cytogeneticdown-regulatesVDRactivatesR-1229-3.573578Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

BAI3down-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

DNAH9down-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

DSTdown-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

FGFR3up-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_CCND2_Calldown-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(4;14)up-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(4;14)_cytogeneticup-regulatesSTAT4activatesR-2655-3.721359Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

AHNAK2up-regulatesATF1repressesR-566-4.357837Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

DIS3up-regulatesATF1repressesR-566-4.357837Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

PTPRDup-regulatesATF1repressesR-566-4.357837Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(11;14)up-regulatesATF1repressesR-566-4.357837Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RNASeq_MAFB_Callup-regulatesATF1repressesR-566-4.357837Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

t(14;16)_cytogeneticup-regulatesATF1repressesR-566-4.357837Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

Regulons in program Pr-115

Regulon Cox Hazard Ratio # genes # causal flows
R-2348-2.83012126
R-1201-2.93735115
R-962-3.1132764
R-1413-3.33652138
R-1229-3.5735787
R-2655-3.7213598
R-566-4.3578376

Genes in program Pr-115

EnsEMBL IdEntrez IdPreferred

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions