Program

Causal Mechanistic Flows with regulons in program Pr-112

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
IRF4up-regulatesRARArepressesR-161-0.21541912Pr-112
t(11;14)up-regulatesRARArepressesR-161-0.21541912Pr-112
del17down-regulatesRARArepressesR-161-0.21541912Pr-112
t(11;14)_cytogeneticup-regulatesRARArepressesR-161-0.21541912Pr-112
DNAH5down-regulatesHBP1repressesR-1838-1.0034311Pr-112
PCDH10down-regulatesHBP1repressesR-1838-1.0034311Pr-112
t(11;14)up-regulatesHBP1repressesR-1838-1.0034311Pr-112
CYLDup-regulatesTRAF4repressesR-3036-1.2304416Pr-112
t(11;14)up-regulatesTRAF4repressesR-3036-1.2304416Pr-112
RNASeq_FGFR3_Calldown-regulatesTRAF4repressesR-3036-1.2304416Pr-112
RNASeq_MAFA_Calldown-regulatesTRAF4repressesR-3036-1.2304416Pr-112
t(4;14)down-regulatesTRAF4repressesR-3036-1.2304416Pr-112
t(4;14)_cytogeneticdown-regulatesTRAF4repressesR-3036-1.2304416Pr-112
NRASdown-regulatesMAFGrepressesR-1491-1.244027Pr-112
t(11;14)up-regulatesMAFGrepressesR-1491-1.244027Pr-112
RNASeq_MAFB_Callup-regulatesMAFGrepressesR-1491-1.244027Pr-112
t(14;16)up-regulatesMAFGrepressesR-1491-1.244027Pr-112
t(11;14)_cytogeneticup-regulatesMAFGrepressesR-1491-1.244027Pr-112
PTPRTup-regulatesRORAactivatesR-2275-1.887618Pr-112
t(11;14)down-regulatesRORAactivatesR-2275-1.887618Pr-112
amp1qup-regulatesRORAactivatesR-2275-1.887618Pr-112
del13up-regulatesRORAactivatesR-2275-1.887618Pr-112
DIS3down-regulatesHMGA1activatesR-835-2.849696Pr-112
FAM46Cup-regulatesHMGA1activatesR-835-2.849696Pr-112
IRF4down-regulatesHMGA1activatesR-835-2.849696Pr-112
t(11;14)down-regulatesHMGA1activatesR-835-2.849696Pr-112
RNASeq_MAFA_Calldown-regulatesHMGA1activatesR-835-2.849696Pr-112
t(11;14)_cytogeneticdown-regulatesHMGA1activatesR-835-2.849696Pr-112
DNAH10up-regulatesSPIBrepressesR-676-3.002517Pr-112
RNASeq_MAFA_Callup-regulatesSPIBrepressesR-676-3.002517Pr-112
RNASeq_MAFB_Callup-regulatesSPIBrepressesR-676-3.002517Pr-112
t(14;16)up-regulatesSPIBrepressesR-676-3.002517Pr-112
MYCdown-regulatesMAFBactivatesR-1746-3.209287Pr-112
FAM46Cdown-regulatesZBTB16repressesR-592-3.367686Pr-112
t(11;14)up-regulatesZBTB16repressesR-592-3.367686Pr-112
t(11;14)_cytogeneticup-regulatesZBTB16repressesR-592-3.367686Pr-112
BAI3down-regulatesTEAD1activatesR-1218-3.912017Pr-112
DSTdown-regulatesTEAD1activatesR-1218-3.912017Pr-112
FGFR3up-regulatesTEAD1activatesR-1218-3.912017Pr-112
KDM3Bdown-regulatesTEAD1activatesR-1218-3.912017Pr-112
t(11;14)down-regulatesTEAD1activatesR-1218-3.912017Pr-112
RNASeq_FGFR3_Callup-regulatesTEAD1activatesR-1218-3.912017Pr-112
RNASeq_MAFA_Calldown-regulatesTEAD1activatesR-1218-3.912017Pr-112
t(4;14)up-regulatesTEAD1activatesR-1218-3.912017Pr-112
t(11;14)_cytogeneticdown-regulatesTEAD1activatesR-1218-3.912017Pr-112
t(4;14)_cytogeneticup-regulatesTEAD1activatesR-1218-3.912017Pr-112

Regulons in program Pr-112

Regulon Cox Hazard Ratio # genes # causal flows
R-161-0.215419124
R-1838-1.00343113
R-3036-1.23044166
R-1491-1.2440275
R-2275-1.8876184
R-835-2.8496966
R-676-3.0025174
R-1746-3.2092871
R-592-3.3676863
R-1218-3.91201710

Genes in program Pr-112

EnsEMBL IdEntrez IdPreferred
ENSG00000177455 930CD19
ENSG00000188243 170622COMMD6
ENSG00000197345 219927MRPL21
ENSG00000197429 3652IPP
ENSG00000219626 375190FAM228B

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions